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Ataxia Telangiectasia

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La maladie veineuse touche dans les sociétés occidentales près d'un individu sur deux. C'est une maladie du vieillissement. Elle atteint l'homme presque autant que la femme. Les facteurs favorisants sont une prédisposition familiale, la station debout prolongé, les facteurs aggravants sont la sédentarité, l'âge et le surpoids. Linsuffisance veineuse représente donc une souffrance pour les patients et un coût de santé public. Elle justifie l'intervention du médecin généraliste auprès de son malade. L'objectif de cet ouvrage est après un rappel des données de bases : épidémiologie, anatomie, physiologie et physiopathologie, cliniques de définir examens complémentaires (imagerie…) et traitements (thérapeutique ou non) et d'informer les praticiens et par delà leur patients des possibilités existantes, de leurs indications, intérêt et complications potentielles.

Diagnosis --- Therapeutics --- drug therapy --- Telangiectases --- Varicose Veins --- WG 620 Varicose veins --- Vascular Diseases --- Venous Insufficiency --- Ataxia Telangiectasia --- Varicose veins --- Ataxia telangiectasia --- Varices --- Ataxie-télangiectasie --- Télangiectasies --- Télangiectasie --- Ataxie-télangiectasie --- Varicose Veins. --- Ataxia Telangiectasia. --- Varices. --- Télangiectasie. --- Sclerotherapy --- Telangiectasis --- diagnosis --- therapy

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This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Werner Syndrome --- n/a --- A549 cells --- epigenetic --- neurodegeneration --- Genome integrity --- adaptation --- cellular senescence --- genome instability --- Werner Syndrome Protein --- lipofuscin --- cell cycle checkpoints --- exonuclease 1 --- template-switching --- energy metabolism --- mutation frequency --- DNA replication --- fork regression --- motor neuron disease --- Microsatellites --- Alzheimer’s disease --- chromatin remodeler --- repair of DNA damage --- AP site analogue --- mutagens --- replication timing --- Thermococcus eurythermalis --- nucleolar stress --- gene expression --- mutations spectra --- origin firing --- Fanconi Anemia --- superfamily 2 ATPase --- DNA translocation --- DNA repair --- SSB signaling --- homologous recombination --- common fragile sites --- 8-chloro-adenosine --- replication --- genome stability --- mutagenicity --- fork reversal --- multiple sclerosis --- non-B DNA --- protein stability --- heterogeneity --- ubiquitin --- SenTraGorTM (GL13) --- replication restart --- EdU --- ?-arrestin --- NER --- aging --- SSB end resection --- oxidative stress --- ATR --- dormant origins --- R loops --- DNA damage response --- Difficult-to-Replicate Sequences --- DNA double-strand repair --- endonuclease IV --- ALS --- double strand break repair --- premature aging --- replication stress --- EXO1 --- POL? --- translesion synthesis --- strand displacements --- G2-arrest --- DNA replication pattern --- SSB repair --- genome integrity --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- MMR --- replicative stress --- senolytics --- spacer --- interactome --- ATR-Chk1 DDR pathway --- C9orf72 --- replication fork restart --- translesion DNA synthesis --- DNA damage --- mismatch repair --- DNA replication stress --- DNA helicase --- Polymerase kappa --- DNA fiber assay --- H1299 cells --- TLS --- APE2 --- ageing --- cell death --- chromosome --- TopBP1 --- barley --- clock proteins --- post-translational modification --- 8-oxoG --- S phase --- ataxia telangiectasia mutated (ATM) --- G protein-coupled receptor (GPCR) --- Polymerase eta --- cancer --- G protein-coupled receptor kinase (GRK) --- helicase --- genomic instability --- Parkinson’s disease --- nucleotide excision repair --- SupF --- Alzheimer's disease --- Parkinson's disease

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Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells.

Medicine --- lipomas --- adipose tissue --- stem cells --- adipogenesis --- osteogenesis --- mesenchymal stem cells --- T-cells --- conditioned medium --- extracellular vesicles --- TLR --- INF-γ --- adipose-derived stromal cells --- equine metabolic syndrome --- metformin --- adipose-derived stem cells --- adipocytes --- differentiation --- collagen I --- adiponectin --- integrins --- discoidin domain-containing receptor --- ageing --- subcutaneous fat --- adipose tissue-derived mesenchymal stromal/stem cells (ASCs) --- cell differentiation --- volatile organic compounds --- metabolic monitoring --- adipose-derived stromal/stem cells --- chondrogenesis --- colony forming unit-fibroblast --- fetal bovine serum --- human platelet lysate --- mesenchymal stem cell --- regenerative medicine --- human adipose-derived stem cells --- stem cell proliferation --- signaling pathway --- adipose-derived mesenchymal stem cells --- migration --- secretion --- primary cilium --- sonic hedgehog signaling --- mesenchymal stromal/stem cells --- perirenal --- fat --- characterization --- stimulation --- lipopolysaccharide --- cytokines --- cytomegalovirus --- angiogenesis --- adipose derived mesenchymal cells --- Histogel --- 3D cell culture --- spheroid culture --- biomaterials --- phenotype --- secretory potential --- ankylosing spondylitis --- systemic lupus erythematosus --- systemic sclerosis --- mesenchymal stromal cells --- breast cancer --- tumor microenvironment --- perineural invasion --- adipose derived stem cells --- valproic acid --- protein interactions --- MAPK pathway --- JAK/STAT pathway --- mesenchymal stromal cell --- tissue of origin --- prolonged culture --- epigenetic memory --- tracking --- bio imaging --- bioluminescence --- qRT-PCR --- Ataxia telangiectasia --- Atm --- n/a