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Biologie --- Analyse cladistique --- Phylogenèse --- Classification --- Histoire --- Aspect moléculaire --- Phylogenèse --- Aspect moléculaire

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"The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target"-- "This book was conceived more than five years before its publication date. It was intended to provide a resource that summarized technology, biochemistry, molecular pathophysiology, and targeted therapeutics. As contributors were being recruited and chapters written the field that was being described changed at an accelerating pace. It is a tribute to scientific progress that volumes like this one are out-of-date as they are published, but books like this are not meant to contain the most current laboratory discovery or report the most recent FDA approval"--

Cancer --- Tumor markers. --- Carcinogenesis. --- Cancer --- Marqueurs tumoraux --- Cancérogenèse --- Molecular aspects. --- Aspect moléculaire

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Cancer. --- Cancer --- Carcinogenesis. --- Cancer --- Cancer --- Cancérogenèse --- Molecular aspects. --- Aspect moléculaire

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In this field there has been an explosion of information generated by scientific research. One of the beneficiaries of this has been the study of morphology, where new techniques and analyses have led to insights into a wide range of topics. Advances in genetics, histology, microstructure, biomechanics and morphometrics have allowed researchers to view teeth from alternative perspectives. However, there has been little communication between researchers in the different fields of dental research. This book brings together overviews on a wide range of dental topics linking genes, molecules and developmental mechanisms within an evolutionary framework. Written by the leading experts in the field, this book will stimulate co-operative research in fields as diverse as paleontology, molecular biology, developmental biology and functional morphology.

Teeth --- Tooth --- Dents --- Physiology --- Evolution --- Molecular aspects --- growth & development --- anatomy & histology --- Physiologie --- Évolution --- Aspect moléculaire --- Physiology. --- Evolution. --- Molecular aspects. --- Aspect moléculaire --- growth & development. --- anatomy & histology. --- Physiologie. --- Évolution. --- Aspect moléculaire.

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Antineoplastic Agents. --- Carcinogenesis --- Antineoplastic agents --- Cancérogenèse --- Anticancéreux --- Molecular aspects --- Development --- Aspect moléculaire --- Développement