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The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemis

Anticoagulants (Medicine) --- Heparin. --- Polysaccharides --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation

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Anticoagulants (Medicine) --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation

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The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.

Anticoagulants (Medicine) --- Warfarin. --- Coumadin (Trademark) --- Coumarins --- Rodenticides --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation --- Pharmacology

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This case-based title reviews anticoagulation management strategies available for a wide variety of clinical scenarios. Designed to aid providers of direct patient care on complex clinical decisions regarding appropriate evidence-based therapy options, patient and agent related variables to consider, as well as expert opinion on the topic.  Oral Anticoagulation Therapy: Cases and Clinical Correlation will provide clinicians and trainees with clear clinical cases, commentary, and resources to develop their knowledge base, problem-solving skills, and ability to practically apply new knowledge to a variety of clinical situations.  Resources provided in cases include valuable figures, tables, and key points designed for the reader to be able to utilize at the point of care.

Medicine. --- Cardiology. --- Medicine & Public Health. --- Anticoagulants (Medicine) --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation --- Heart --- Internal medicine --- Diseases

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Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.

Anticoagulants (Medicine) --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation --- Toxicology and Pharmaceutical Science --- Pharmacology --- Pharmacokinetics --- Drug Discovery --- Health Sciences