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Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Antisense nucleic acids --- Antisense Elements (Genetics) --- Therapeutic use. --- pharmacology. --- therapeutic use. --- Pharmacology. --- Therapeutic use --- Molecular biology. --- Cancer research. --- Human physiology. --- Oncology . --- Pharmacology/Toxicology. --- Molecular Medicine. --- Cancer Research. --- Human Physiology. --- Oncology. --- Tumors --- Human biology --- Medical sciences --- Physiology --- Human body --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Antisense nucleotides --- Nucleic acids
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Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research.The critically acclaimed
Acide nucleique [Ribo] --- Acide ribonucléique --- Acides nucléiques antisens --- Antisense nucleic acids --- Antisense nucleinezuren --- Oligonucleotiden --- Oligonucleotides --- Oligonucléotides --- RNA (Nucleic acid) --- Ribonucleic acid --- Ribonucleïnezuur --- Ribose nucleic acid --- Zuur [Nucleine] [Ribo] --- Antisense nucleic acids. --- Antisense DNA. --- Complementary DNA --- Antisense nucleotides --- Antisense RNA. --- Complementary RNA --- DNA --- Nucleic acids --- RNA --- Oligonucleotides, antisense --- Receptors --- Therapy
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Antisense nucleic acids --- Antisense peptides --- Antisense Elements (Genetics) --- Gene Expression --- Nucleic Acids. --- Antisense nucleic acids. --- Antisense peptides. --- drug effects. --- Antisense nucleotides --- Acids, Nucleic --- Anti-Sense Elements --- Anti-Sense Probes --- Antisense Probes --- Anti Sense Elements --- Anti Sense Probes --- Elements, Anti-Sense --- Probes, Anti-Sense --- Probes, Antisense --- Antisense proteins --- Peptides --- Nucleic acids --- Nucleic Acids --- drug effects --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Gene Expression Profiling --- Nucleic Acid --- Acid, Nucleic
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This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Antisense nucleic acids. --- Antisense peptides. --- Antisense proteins --- Peptides --- Antisense nucleotides --- Nucleic acids --- Human genetics. --- Biochemistry. --- Immunology. --- Neurosciences. --- Biotechnology. --- Human Genetics. --- Medical Biochemistry. --- Biochemistry, general. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Chemical engineering --- Genetic engineering --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Composition --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology
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DNA, Antisense --- Gene Expression Regulation --- RNA, Antisense --- Antisense nucleic acids --- Acides nucléiques antisens --- DNA, Antisense. --- Gene Expression Regulation. --- RNA, Antisense. --- Antisense nucleotides --- Nucleic acids --- Anti-Sense RNA --- Antisense RNA --- Anti Sense RNA --- RNA, Anti-Sense --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Anti-Sense DNA --- Antisense DNA --- Anti Sense DNA --- DNA, Anti-Sense --- Antisense nucleic acids. --- Dna, antisense. --- Gene expression regulation. --- Rna, antisense. --- Acides nucléiques antisens
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Antisense nucleic acids --- Antisense peptides --- Antisense Elements (Genetics) --- DNA, Antisense --- Antisense-Nucleinsäuren. --- Zeitschrift. --- DNA, Antisense. --- Antisense nucleic acids. --- Antisense peptides. --- Antisense nucleotides --- Anti-Sense DNA --- Antisense DNA --- Anti Sense DNA --- DNA, Anti-Sense --- Anti-Sense Elements --- Anti-Sense Probes --- Antisense Probes --- Anti Sense Elements --- Anti Sense Probes --- Elements, Anti-Sense --- Probes, Anti-Sense --- Probes, Antisense --- Antisense proteins --- Antisense Elements (Genetics). --- Peptides --- Nucleic acids --- Antisense-Nucleinsäuren --- Zeitschrift --- Periodikum --- Zeitschriften --- Presse --- Fortlaufendes Sammelwerk --- Antisense-Nukleinsäuren --- Antisense-Nucleotidsequenz --- Basenkomplimentäre-Nucleotidsequenz --- Nucleinsäuren --- Molecular Biology. --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Antisense-Nukleinsäuren --- Basenkomplimentäre-Nucleotidsequenz --- Nucleinsäuren
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Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs. Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.
Antisense nucleic acids --- Oligonucleotides, Antisense --- Therapeutic use --- therapeutic use --- pharmacology --- Therapeutic use. --- therapeutic use. --- pharmacology. --- Antisense nucleic acids -- Physiological effect. --- Antisense nucleic acids -- Therapeutic use. --- Electronic books. -- local. --- Antisense Elements (Genetics) --- Oligonucleotides --- Biological Science Disciplines --- Polynucleotides --- Natural Science Disciplines --- Nucleic Acids, Nucleotides, and Nucleosides --- Nucleic Acid Probes --- Nucleic Acids --- Disciplines and Occupations --- Chemicals and Drugs --- Molecular Probes --- Nucleotides --- Laboratory Chemicals --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Pharmacology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Pharmacology. --- Physiological effect. --- Antisense nucleotides --- Nucleic acids --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells
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