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MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases.
MicroRNA. --- MicroRNA --- Micro RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Primary MicroRNA --- Primary miRNA --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA --- Health aspects. --- MicroRNAs
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Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research.The critically acclaimed
Acide nucleique [Ribo] --- Acide ribonucléique --- Acides nucléiques antisens --- Antisense nucleic acids --- Antisense nucleinezuren --- Oligonucleotiden --- Oligonucleotides --- Oligonucléotides --- RNA (Nucleic acid) --- Ribonucleic acid --- Ribonucleïnezuur --- Ribose nucleic acid --- Zuur [Nucleine] [Ribo] --- Antisense nucleic acids. --- Antisense DNA. --- Complementary DNA --- Antisense nucleotides --- Antisense RNA. --- Complementary RNA --- DNA --- Nucleic acids --- RNA --- Oligonucleotides, antisense --- Receptors --- Therapy
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MicroRNA. --- MicroRNAs. --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA
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MicroRNA --- Systems biology. --- Cancer --- Health aspects. --- Genetic aspects --- Research. --- Micro RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Primary MicroRNA --- Primary miRNA --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Càncer --- Genètica mèdica --- Micro RNAs --- Biologia de sistemes --- Investigació mèdica
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DNA, Antisense --- Gene Expression Regulation --- RNA, Antisense --- Antisense nucleic acids --- Acides nucléiques antisens --- DNA, Antisense. --- Gene Expression Regulation. --- RNA, Antisense. --- Antisense nucleotides --- Nucleic acids --- Anti-Sense RNA --- Antisense RNA --- Anti Sense RNA --- RNA, Anti-Sense --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Anti-Sense DNA --- Antisense DNA --- Anti Sense DNA --- DNA, Anti-Sense --- Antisense nucleic acids. --- Dna, antisense. --- Gene expression regulation. --- Rna, antisense. --- Acides nucléiques antisens
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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers research methods in biomineralization scienceContains sections on such topics as riboswitch discovery and valid
Small interfering RNA. --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Antisense RNA
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Small interfering RNA. --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Antisense RNA
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Small interfering RNA. --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Antisense RNA
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New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz.
Nucleic acids --- Biological Science Disciplines --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Natural Science Disciplines --- Disciplines and Occupations --- Nucleic Acids --- Pharmacology --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Organic Chemistry --- Pharmacy, Therapeutics, & Pharmacology --- Therapeutic use --- Antisense RNA --- Therapeutic use. --- Complementary RNA --- Polynucleotides --- Chemistry. --- Pharmacy. --- Electrochemistry. --- Polymers. --- Medicinal chemistry. --- Biochemistry. --- Polymer Sciences. --- Medicinal Chemistry. --- Biochemistry, general. --- Antisense nucleic acids --- RNA --- Biomolecules --- Physical sciences --- Medicine --- Drugs --- Materia medica --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Composition --- Polymers . --- Chemistry, Physical and theoretical --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry
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The past decade has witnessed a true revolution in our understanding of how RNA molecules can reduce or silence gene expression, a process that holds great promise in basic research and for antiviral and anticancer applications. In RNA Silencing: Methods and Protocols, many of the most notable and distinguished researchers in the field describe in step-by-step detail their best methods for the design, preparation, and use of RNAs to reduce gene expression in cells and organisms. The techniques range widely and include methods addressing the biochemical aspects of the silencing machinery, RNA silencing in non-mammalian organisms, and the in vivo delivery of siRNAs and silencing vectors. There are also techniques for designing, preparing, and using RNAs to silence gene expression, for fine-tuning regulation by targeting specific isoforms of a given gene, and for the study and use of microRNAs. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, RNA Silencing: Methods and Protocols offers today's laboratory investigators a host of optimized and validated techniques to study RNA silencing and translate its concepts into successful practical applications.
Gene expression regulation --- Gene silencing --- Micrornas --- Rna interference. --- Rna, small interfering --- Small interfering rna --- Genetics. --- Physiology. --- Small interfering RNA --- Gene inactivation --- Inactivation, Gene --- Silencing, Gene --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Genetic regulation --- Antisense RNA --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists
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