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Skin inflammation is associated with a wide range of conditions which represent major health issues worldwide. Skin and mucosal surfaces represent the primary interface between the human body and the environment, susceptible to numerous factors whose action results in diseases produced by chemical substances, mechanical trauma, microbial agents, radiation, etc. Inflammation, a complex network of interactions between soluble molecules and cells, represents the main modality of the skin’s response to injuries. Numerous studies have revealed close links between chronic inflammation, oxidative stress, and carcinogenesis. Chronic inflammation induces the activation of various cell types and an increase in the production of reactive oxygen species, promoting the initiation of a malignant process. Identifying specific biomarkers is essential for understanding molecular mechanisms and developing therapies appropriate to the patient’s characteristics.Personalized medicine is an emerging field of medicine that has the potential to predict which therapy will be safe and efficacious for specific patients using an individual’s genetic profile to guide decisions regarding the diagnosis, treatment, as well as prevention of disease. This book gathers articles that present recent advancements in research involving the mechanisms that underlie the development of inflammatory skin disorders, skin and mucosal inflammation in general.

sea-buckthorn seed oil --- long-chain fatty acids --- skin dysplastic keratinocytes --- UVA --- CD36 --- SR-B2 --- atopic dermatitis --- eczema --- JAK inhibitors --- systematic review --- meta-analysis --- evidence-based medicine --- immune-mediated skin diseases --- target therapy --- skin conditions and systemic inflammatory diseases --- systemic sclerosis --- biomarker --- calumenin --- S100A6 --- cytohesin 2 --- cannabinoids --- inflammation --- gut-lung-skin barrier --- signaling pathways --- inflammatory biomarkers --- psoriasis vulgaris --- prevalence --- comorbidities --- risk factors --- systemic lupus erythematous --- lupus nephritis --- lipid peroxidation --- DNA oxidation --- oxidized proteins --- carbohydrate oxidation --- antioxidative stress strategies --- biomarkers --- IgY --- psoriatic dermatitis --- imiquimod --- C57 BL/6 mice --- alginate --- biomaterial --- dressing --- fibers --- hydrogel --- nanofibers --- commercially available --- wound care --- wound healing --- cutaneous melanoma --- epigenetic regulation --- drug resistance --- therapeutic targets --- epigenetic therapy --- immune response --- Sutton nevi --- halo nevi --- skin tumor --- psoriasis --- proteome analysis --- estrogen --- menopause --- cSCC --- AK --- sialylation --- sialyltransferase --- sialidase --- COVID-19 --- pyoderma gangrenosum --- immunosuppression --- cyclosporine --- corticosteroids --- autoinflammatory disease --- androgenic alopecia --- clinical trial --- hair density --- platelet-rich plasma --- n/a

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Biology --- Free Radicals --- Medicine --- Oxidation-Reduction --- Oxidative Stress --- Peroxidases --- Free radicals (Chemistry) --- Oxidation, Physiological --- Radicaux libres (Chimie) --- Oxydation biologique --- Periodicals. --- periodicals. --- Pathophysiology --- Periodicals --- Physiopathologie --- Périodiques --- Biology. --- Free Radicals. --- Medicine. --- Oxidation-Reduction. --- Oxidative Stress. --- Peroxidases. --- Oxidation, Physiological. --- Pathophysiology. --- Health Sciences --- Life Sciences --- Pathology --- free radicals --- oxidative stress --- activated oxygen --- redox processes --- perioxidative processes --- Ovoperoxidase --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Redox --- Oxidation Reduction --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Radicals, Free --- Free Radical Scavengers --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Radicals (Chemistry) --- Free radical reactions --- Health Workforce --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative --- Free Radical --- Radical, Free --- Radicals lliures (Química) --- Reacció d'oxidació-reducció --- Oxigen --- Reacció d'oxidació-reducció. --- Oxigen.

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This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.

Cytology --- Biology --- Health & Biological Sciences --- Toxicology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemicals --- Toxicology --- Life sciences. --- Apoptosis. --- Oxidative stress. --- Environmental health. --- Life Sciences. --- Oxidative Stress. --- Pharmacology/Toxicology. --- Environmental Health. --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Physiological effect --- Cytology. --- Environmental Medicine. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Toxicological Phenomena. --- Pharmacological Phenomena. --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Toxicologic Phenomena --- Toxicologic Phenomenon --- Toxicological Concepts --- Toxicological Phenomenon --- Concept, Toxicological --- Concepts, Toxicological --- Phenomena, Toxicologic --- Phenomena, Toxicological --- Phenomenon, Toxicologic --- Phenomenon, Toxicological --- Toxicological Concept --- Environmental quality --- Health --- Health ecology --- Public health --- Environmental engineering --- Health risk assessment --- Cell death --- Oxidation-reduction reaction --- Stress (Physiology) --- Health aspects --- Environmental aspects --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative