Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Depression, Mental --- Antidepressive Agents --- Depression --- Family Practice --- Family Practices --- Practice, Family --- Practices, Family --- Emotional Depression --- Depressive Symptoms --- Depression, Emotional --- Depressions --- Depressions, Emotional --- Depressive Symptom --- Emotional Depressions --- Symptom, Depressive --- Symptoms, Depressive --- Antidepressant Drugs --- Antidepressant --- Antidepressant Drug --- Antidepressants --- Antidepressive Agent --- Thymoanaleptic --- Thymoanaleptics --- Thymoleptic --- Thymoleptics --- Agent, Antidepressive --- Agents, Antidepressive --- Drug, Antidepressant --- Drugs, Antidepressant --- Monoamine Oxidase Inhibitors --- Congresses

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent clinical evidence supports the potential of neurokinin NK1 receptor antagonists as novel antidepressant drugs. A number of NK1 antagonists have reduced affinity for rat and mouse NK1 receptors compared to human, making it difficult to test for efficacy in traditional animal models. NK1 antagonists, in general, have similar affinity at gerbil and human NK1 receptors. The aims of these studies were, first to validate the gerbil tail suspension test, a test used frequently to demonstrate antidepressant drug efficacy in mice, and second, to determine whether the test could be used to demonstrate the antidepressant potential of NK1 antagonists. Immobility time was reduced by oral administration of the antidepressants imipramine (3-30 mg/kg), desipramine (1-30 mg/kg), amitriptyline (30 mg/kg), fluoxetine (1-30 mg/kg), paroxetine (3-10 mg/kg), citalopram (0.1-3 mg/kg), sertraline (1-30 mg/kg), venlafaxine (1-30 mg/kg) and nefazodone (100 mg/kg). Furthermore, oral administration of the NK1 antagonists M K-869 (10 mg/kg), L-742,694 (110 mg/kg), L-733,060 (10 mg/kg), CP-99,994 (30 mg/kg), and CP-122,721 (3-30 mg/kg) reduced immobility time. Diazepam (1-10 mg/kg), chlordiazepoxide (1-10 mg/kg), buspirone (3-30 mgAg), FG-7142 (1-30 mg/kg), and haloperidol (1-10 mg/kg) did not reduce immobility. Amphetamine (0.3-10 mg/kg) and atropine (0.3-10 mg/kg) reduced immobility, suggesting susceptibility to false positives, e.g. compounds that affect locomotion. Compounds were therefore tested in a gerbil locomotor activity (LMA) test to ensure that the antidepressant-like effects were not secondary to effects on activity. Antidepressant drugs and NK1 antagonists had no effect on LMA at doses that reduced immobility, whereas amphetamine and atropine induced marked hyperactivity. These studies support both the utility of gerbils in behavioral pharmacology and the antidepressant potential of selective NK1 antagonists

Activity. --- Amphetamine. --- Animal model. --- Animal-model. --- Animal-models. --- Animal. --- Antidepressant drugs. --- Antidepressant. --- Anxiolytic-like. --- Atropine. --- Behavior. --- Blockade. --- Citalopram. --- Depression. --- Diazepam. --- Drug. --- Drugs. --- Fluoxetine. --- Gerbil. --- Gerbils. --- Haloperidol. --- Human. --- Hyperactivity. --- Immobility. --- Inhibition. --- Locomotion. --- Locomotor activity. --- Locomotor-activity. --- Mice. --- Model. --- Models. --- Mouse. --- Neurokinin nk1 receptor antagonists. --- Neurokinin nk1 receptor. --- Nk1 receptor antagonists. --- Nonpeptide antagonist. --- Pharmacology. --- Rat. --- Receptor antagonist. --- Receptor. --- Receptors. --- Social-interaction. --- Substance p. --- Substance-p receptors. --- Susceptibility. --- Tail suspension test. --- Test. --- Time.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Antidepressive Agents. --- Psychotropic Drugs. --- Tranquilizing Agents. --- Tranquilizing Drugs --- Tranquilizing Effect --- Tranquilizing Effects --- Tranquillizing Agents --- Tranquillizing Drugs --- Ataractics --- Agents, Tranquilizing --- Agents, Tranquillizing --- Drugs, Tranquilizing --- Drugs, Tranquillizing --- Effect, Tranquilizing --- Effects, Tranquilizing --- Hypnotics and Sedatives --- Psychoactive Drugs --- Psychoactive Agents --- Psychopharmaceuticals --- Agents, Psychoactive --- Drugs, Psychoactive --- Drugs, Psychotropic --- Psychopharmacology --- Antidepressant Drugs --- Antidepressants --- Thymoanaleptics --- Thymoleptics --- Agents, Antidepressive --- Drugs, Antidepressant --- Depression --- Monoamine Oxidase Inhibitors --- Antidepressive agents --- Psychotropic drugs. --- Tranquilizing agents --- Antidepressive agents. --- Tranquilizing agents. --- Psychoactive Agent --- Psychoactive Drug --- Psychopharmaceutical --- Psychotropic Drug --- Agent, Psychoactive --- Drug, Psychoactive --- Drug, Psychotropic --- Antidepressant --- Antidepressant Drug --- Antidepressive Agent --- Thymoanaleptic --- Thymoleptic --- Agent, Antidepressive --- Drug, Antidepressant --- Antidepressive Agents --- Psychotropic Drugs --- Tranquilizing Agents

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Prozak Diaries is an analysis of emerging psychiatric discourses in post-1980s Iran. It examines a cultural shift in how people interpret and express their feeling states, by adopting the language of psychiatry, and shows how experiences that were once articulated in the richly layered poetics of the Persian language became, by the 1990s, part of a clinical discourse on mood and affect. In asking how psychiatric dialect becomes a language of everyday, the book analyzes cultural forms created by this clinical discourse, exploring individual, professional, and generational cultures of medicalization in various sites from clinical encounters and psychiatric training, to intimate interviews, works of art and media, and Persian blogs. Through the lens of psychiatry, the book reveals how historical experiences are negotiated and how generations are formed. Orkideh Behrouzan traces the historical circumstances that prompted the development of psychiatric discourses in Iran and reveals the ways in which they both reflect and actively shape Iranians' cultural sensibilities. A physician and an anthropologist, she combines clinical and anthropological perspectives in order to investigate the gray areas between memory and everyday life, between individual symptoms and generational remembering. Prozak Diaries offers an exploration of language as experience. In interpreting clinical and generational narratives, Behrouzan writes not only a history of psychiatry in contemporary Iran, but a story of how stories are told.

Psychiatry --- Depression, Mental --- Youth --- Medical anthropology --- Depressive Disorder. --- Psychiatry. --- Anthropology, Medical. --- Antidepressive Agents. --- Adolescent. --- #SBIB:39A8 --- #SBIB:39A9 --- #SBIB:39A77 --- Adolescents --- Adolescents, Female --- Adolescents, Male --- Teenagers --- Teens --- Adolescence --- Adolescent, Female --- Adolescent, Male --- Female Adolescent --- Female Adolescents --- Male Adolescent --- Male Adolescents --- Teen --- Teenager --- Youths --- Minors --- Antidepressant Drugs --- Antidepressant --- Antidepressant Drug --- Antidepressants --- Antidepressive Agent --- Thymoanaleptic --- Thymoanaleptics --- Thymoleptic --- Thymoleptics --- Agent, Antidepressive --- Agents, Antidepressive --- Drug, Antidepressant --- Drugs, Antidepressant --- Depression --- Monoamine Oxidase Inhibitors --- Psychiatrists --- Psychiatrist --- Medical Anthropology --- Depression, Endogenous --- Depression, Neurotic --- Depression, Unipolar --- Depressive Syndrome --- Melancholia --- Neurosis, Depressive --- Unipolar Depression --- Depressions, Endogenous --- Depressions, Neurotic --- Depressions, Unipolar --- Depressive Disorders --- Depressive Neuroses --- Depressive Neurosis --- Depressive Syndromes --- Disorder, Depressive --- Disorders, Depressive --- Endogenous Depression --- Endogenous Depressions --- Melancholias --- Neuroses, Depressive --- Neurotic Depression --- Neurotic Depressions --- Syndrome, Depressive --- Syndromes, Depressive --- Unipolar Depressions --- Medical care --- Medicine --- Anthropology --- Young people --- Young persons --- Youngsters --- Age groups --- Life cycle, Human --- Dejection --- Depressive disorder --- Depressive psychoses --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Psychology. --- Antropologie: linguïstiek, audiovisuele cultuur, antropologie van media en representatie --- Medische antropologie / gezondheid / handicaps --- Etnografie: Noord-Afrika en het Midden-Oosten --- Anthropological aspects --- Iran. --- Islamic Republic of Iran --- Sociology of culture --- Iran --- Depressive Disorder --- Anthropology, Medical --- Antidepressive Agents --- Adolescent --- Psychology --- Bipolar disorder