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In this book, you'll find the latest updates about the current use of anticoagulants in medical practice. This includes clinical pharmacotherapy, laboratory monitoring, and antidotes. You'll also find a special focus on heparin-induced thrombocytopenia, including various mechanisms and presentations. Finally, you'll find important details that will help you to understand what patients receiving anticoagulants know about these drugs and how to improve their quality of life.

Blood --- Anticoagulants (Medicine) --- Coagulation.

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In this book, you'll find the latest updates about the current use of anticoagulants in medical practice. This includes clinical pharmacotherapy, laboratory monitoring, and antidotes. You'll also find a special focus on heparin-induced thrombocytopenia, including various mechanisms and presentations. Finally, you'll find important details that will help you to understand what patients receiving anticoagulants know about these drugs and how to improve their quality of life.

Blood --- Anticoagulants (Medicine) --- Coagulation.

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Venous thromboembolic (VTE) events are important causes of morbidity in elective total hip replacement (THR) and total knee replacement (TKR) procedures. Current guidelines recommend thromboprophylaxis in patients undergoing THR or TKR, although the American Academy of Orthopaedic Surgeons (AAOS) guidelines suggest individual assessment of patients when choosing the specific thromboprophylaxis strategy. Low molecular weight heparin (LMWH) and adjusted-dose warfarin are the most commonly used anticoagulants for thromboprophylaxis in the United States, but a number of other treatment options are available, including unfractionated heparin, aspirin, mechanical devices, and newer oral anticoagulants.^Prior to 1980, rates of symptomatic VTE were 15 to 30 percent.^However, improved surgical care and techniques have decreased the rate of symptomatic VTE.^A recent analysis that incorporated data from trials and observational studies estimated the contemporary 35-day rate of symptomatic VTE without thromboprophylaxis at 4.3 percent. Pharmacological thromboprophylaxis for THR or TKR surgery decreases VTE by approximately 50 percent but with the tradeoff of increased bleeding. The risk of bleeding is a concern because bleeding can lead to infections, reoperation, delayed wound healing, and extended hospital stay. The choice of which antithrombotic thus becomes pivotal for balancing the prevention of thromboembolism with the risk of bleeding.^Newer oral anticoagulants have been developed with the goal of overcoming the limitations of warfarin and the available parenteral agents.^These newer anticoagulants belong to two drug classes, based on their target coagulation protein: factor Xa (FXa) inhibitors and direct thrombin inhibitors (DTIs).^These drugs are given as fixed oral doses and have the advantage of a more predictable anticoagulant effect, eliminating the need for monitoring when used for short-term thromboprophylaxis. Disadvantages of newer oral anticoagulants include the lack of specific antidotes to reverse their anticoagulant effect in a timely fashion in case of bleeding, and drug costs. Given the emerging data on new oral anticoagulants, this report was commissioned by the VA to examine the following key questions (KQs):1.^KQ 1.^For patients undergoing total hip or total knee replacement, what is the comparative effectiveness of newer oral anticoagulants and standard drug classes (low molecular weight heparin, injectable factor Xa inhibitors, unfractionated heparin, warfarin, aspirin) on the incidence of symptomatic, objectively confirmed venous thromboembolism (VTE), other VTE events, total mortality, and bleeding outcomes?2. KQ2.^For patients undergoing total hip or total knee replacement, what are the effects of combined pharmacological and mechanical modalities versus pharmacological treatment alone on the incidence of symptomatic, objectively confirmed VTE, other VTE events, total mortality, and bleeding outcomes?3. KQ3. For patients undergoing total hip or total knee replacement, what is the comparative efficacy of individual newer oral anticoagulants on the incidence of symptomatic, objectively confirmed VTE, other VTE events, total mortality, and bleeding outcomes?

Anticoagulants (Medicine) --- United States.

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Thrombotic diseases are some of the leading causes of death in the world. Anticoagulation is a mainstay approach for the prophylaxis and treatment of thrombotic diseases. This book includes six chapters regarding the mechanisms of anticoagulation and its clinical value in different disease conditions. The first two chapters summarize the general information regarding anticoagulation and hypercoagulability/thrombophilia, and the remaining four chapters discuss the use of anticoagulation in different populations, including adult hospitalized surgical and medical patients, COVID-19 patients, patients with hepatic thrombotic disorders, and frail elderly patients with atrial fibrillation.

Hematology. --- Anticoagulants (Medicine)

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Anticoagulants (Medicine) --- Anticoagulants (Medicine) --- Medication errors --- Side effects. --- Prevention.