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Anthracyclines

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Anthracyclines - Congresses.

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Anthracyclines drugs are used as a treatment regime to combat cancer owing to their great chemotherapeutic potential. They are characterized by the presence of a wide range of derivatives, the most famous are doxorubicin and daunorubicin. The proposed action mechanism of anthracyclines and their derivatives to exert cytotoxic effect involves the intercalation of the drug molecule into nucleic acid and inhibition of the activity of topoisomerases. These events consequences in halting DNA replication and transcription mechanisms of the cell. Understanding of the structural and conformational changes associated with nucleic acid after binding with drugs provides significant knowledge for the development of more effective drugs. A comprehensive elucidation of the molecular mechanism(s) of action of anthracyclines drugs plays a significant role in the rational drug designing to obtain an effective, selective, and safe anti-cancer drugs.

Anthracyclines. --- Aminoglycosides --- Antineoplastic antibiotics --- Polycyclic compounds

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Anthracyclines --- Cancer --- Drugs --- Antibiotics, Antineoplastic --- Testing --- Congresses --- Chemotherapy --- Congresses --- Structure-activity relationships --- Congresses

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table of contents.

Chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Biochemistry, general. --- Chemistry, Organic. --- Biochemistry. --- Chimie --- Chimie organique --- Biochimie --- Anthracyclines --- Biochemistry --- Oncology --- Chemistry --- Medicine --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Anthracyclines. --- Pharmaceutical chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Organic chemistry. --- Medicinal chemistry. --- Aminoglycosides --- Antineoplastic antibiotics --- Polycyclic compounds --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Organic chemistry --- Composition