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Despite the difficulty in comparing clinic-based human tests with animal model testing, there is still great value in pursuing translational approaches, as tests and treatment strategies might be developed to improve brain function in humans suffering from neurological conditions and knowledge obtained from human behavioral studies can be used to further improve the animal models of behavioral analysis. In Animal Models of Behavioral Analysis, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans not only to increase our understanding of brain function across species but also to provide objective performance measures and bridge the gap between behavioral alterations in humans with cognitive disorders and the correlating animal models of these conditions. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Provocative and cutting-edge, Animal Models of Behavioral Analysis seeks to aid researchers in further developing these vital techniques in an effort to advance studies in both the clinic and the laboratory.

Behavioral assessment. --- Animal models. --- Behavioral assessment --- Behavioral Sciences --- Research --- Investigative Techniques --- Psychology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Science --- Behavioral Disciplines and Activities --- Behavioral Research --- Models, Animal --- Psychology, Comparative --- Natural Science Disciplines --- Psychiatry and Psychology --- Disciplines and Occupations --- Medicine --- Social Sciences --- Health & Biological Sciences --- Neurology --- Animal models --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Comparative Psychology --- Comparative Psychologies --- Psychologies, Comparative --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Research, Behavioral --- Sciences --- Factors, Psychological --- Psychological Factors --- Psychological Side Effects --- Psychologists --- Psychosocial Factors --- Side Effects, Psychological --- Factor, Psychological --- Factor, Psychosocial --- Factors, Psychosocial --- Psychological Factor --- Psychological Side Effect --- Psychologist --- Psychosocial Factor --- Side Effect, Psychological --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Laboratory Research --- Research Activities --- Research and Development --- Research Priorities --- Activities, Research --- Activity, Research --- Development and Research --- Priorities, Research --- Priority, Research --- Research Activity --- Research Priority --- Research, Laboratory --- Proxemics --- Behavioral Science --- Proxemic --- Science, Behavioral --- Sciences, Behavioral --- Assessment of behavior --- Behavior assessment --- Behavioral analysis --- Behavioral evaluation --- Neurosciences. --- Neurology. --- Laboratory animals. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases

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Bone Regeneration --- Tissue Engineering --- Bone Transplantation --- Bone regeneration --- Tissue engineering. --- Bone-grafting --- Bones --- Os --- Génie tissulaire --- Cytology. --- Régénération --- Greffe --- Cytologie --- Bone Transplantation. --- Bone and Bones --- Models, Animal --- Research Design --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- Data Adjustment --- Data Reporting --- Design, Experimental --- Designs, Experimental --- Error Sources --- Experimental Designs --- Matched Groups --- Methodology, Research --- Problem Formulation --- Research Methodology --- Research Proposal --- Research Strategy --- Research Technics --- Research Techniques --- Scoring Methods --- Experimental Design --- Adjustment, Data --- Adjustments, Data --- Data Adjustments --- Design, Research --- Designs, Research --- Error Source --- Formulation, Problem --- Formulations, Problem --- Group, Matched --- Groups, Matched --- Matched Group --- Method, Scoring --- Methods, Scoring --- Problem Formulations --- Proposal, Research --- Proposals, Research --- Reporting, Data --- Research Designs --- Research Proposals --- Research Strategies --- Research Technic --- Research Technique --- Scoring Method --- Source, Error --- Sources, Error --- Strategies, Research --- Strategy, Research --- Technic, Research --- Technics, Research --- Technique, Research --- Techniques, Research --- Research --- Clinical Trials Data Monitoring Committees --- cytology --- methods --- Bone Regeneration. --- Tissue Engineering.

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Cancer patients have benefitted greatly from recent advances in the drugs, dose regimens, and combinations used to treat their primary tumor and for the treatment or prevention of spread of their disease. Due to the advances in chemotherapy and other aspects of prevention, early detection, and treatment modalities, an increasing percentage of patients are surviving the disease. For some types of cancer, the majority of patients live decades beyond their diagnosis. For this they are forever thankful and appreciative of the drugs that helped lead to this increased survival rate. But no drug is devoid of adverse effects. This also applies to chemotherapeutic agents. The acute cytotoxic effects of these agents are well known––indeed are often required for their therapeutic benefit. The chronic adverse effects are varied and in some cases less well known. With the increase in survival rates, there has emerged a new awareness of these chronic adverse effects.

Antineoplastic agents --Side effects. --- Cancer --Chemotherapy --Complications. --- Cognition disorders. --- Neurotoxic agents. --- Cancer --- Cognition disorders --- Antineoplastic agents --- Neurotoxic agents --- Nervous System Diseases --- Kinetics --- Therapeutics --- Investigative Techniques --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Poisoning --- Therapeutic Uses --- Mental Disorders --- Substance-Related Disorders --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Pharmacologic Actions --- Psychiatry and Psychology --- Chemical Actions and Uses --- Chemical Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Drug Therapy --- Pharmacokinetics --- Cognition Disorders --- Neurotoxicity Syndromes --- Antineoplastic Agents --- Models, Animal --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Complications --- Side effects --- Complications. --- Side effects. --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Cognitive disorders --- Complications and sequelae --- Medicine. --- Cancer research. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Poisons --- Drugs --- Psychology, Pathological --- Oncology. --- Tumors --- Health Workforce --- Biomedicine, general. --- Neurotoxicity Syndromes. --- Drug-Related Side Effects and Adverse Reactions. --- Models, Animal. --- chemically induced. --- pharmacokinetics. --- toxicity. --- Animals, Model. --- Encephalopathy, Toxic --- Nervous System Poisoning --- Neurotoxic Disorders --- Neurotoxin Diseases --- Neurotoxin Disorders --- Toxic Encephalitis --- Poisoning, Nervous System --- Encephalitides, Toxic --- Encephalitis, Toxic --- Encephalopathies, Toxic --- Nervous System Poisonings --- Neurotoxic Disorder --- Neurotoxicity Syndrome --- Neurotoxin Disease --- Neurotoxin Disorder --- Poisonings, Nervous System --- Syndrome, Neurotoxicity --- Syndromes, Neurotoxicity --- Toxic Encephalitides --- Toxic Encephalopathies --- Toxic Encephalopathy --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- adverse effects --- toxicity --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation

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Immune System Diseases --- Immune diseases --- Immune disorders --- Immunité [Maladies de l' ] --- Immunité [Troubles de l' ] --- Immunologic diseases --- Immunologic disorders --- Immunological diseases --- Immunologische ziekten --- Maladies immunitaires --- Maladies immunologiques --- Retroviruses --- Retrovirussen --- Rétrovirus --- Système immunitaire--Maladies --- RETROVIRIDAE --- Retroviridae Infections --- ACQUIRED IMMUNODEFICIENCY SYNDROME --- DISEASE MODELS, ANIMAL --- Immunologic Deficiency Syndromes --- Neoplasms --- veterinary --- Acquired Immunodeficiency Syndrome --- Retrovirus infections --- DISEASE MODELS --- IMMUNOLOGIC DEFICIENCY SYNDROMES --- NEOPLASMS --- Retroviridae --- RETROVIRUS INFECTIONS --- animals --- Acquired Immunodeficiency Syndrome. --- Retrovirus infections. --- Retroviridae. --- animals. --- veterinary. --- Acquired immunodeficiency syndrome. --- Disease models --- Immunologic deficiency syndromes --- Animals. --- Veterinary. --- Animals --- Diseases --- RNA Virus Infections --- RNA Viruses --- Oncogenic Viruses --- Models, Biological --- Animal Diseases --- Models, Animal --- Viruses --- Investigative Techniques --- Vertebrate Viruses --- Virus Diseases --- Models, Theoretical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Organisms --- Disease Models, Animal --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Tumor Viruses --- Oncogenic Virus --- Tumor Virus --- Virus, Oncogenic --- Virus, Tumor --- Viruses, Oncogenic --- Viruses, Tumor --- Carcinogens --- RNA Rodent Viruses --- RNA Rodent Virus --- RNA Virus --- Rodent Virus, RNA --- Rodent Viruses, RNA --- Virus, RNA --- Virus, RNA Rodent --- Viruses, RNA --- Viruses, RNA Rodent --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Diseases, Animal --- Disease --- Veterinary Medicine --- Deficiency Syndrome, Immunologic --- Deficiency Syndromes, Antibody --- Deficiency Syndromes, Immunologic --- Immunologic Deficiency Syndrome --- Immunological Deficiency Syndromes --- Antibody Deficiency Syndrome --- Antibody Deficiency Syndromes --- Deficiency Syndrome, Antibody --- Deficiency Syndrome, Immunological --- Deficiency Syndromes, Immunological --- Immunological Deficiency Syndrome --- Syndrome, Antibody Deficiency --- Syndrome, Immunologic Deficiency --- Syndrome, Immunological Deficiency --- Syndromes, Antibody Deficiency --- Syndromes, Immunologic Deficiency --- Syndromes, Immunological Deficiency --- Antibodies --- Infections, Retroviridae --- Infections, Retrovirus --- XMRV Infection --- Xenotropic MuLV-related Virus Infection --- Xenotropic Murine Leukemia Virus-related Virus Infection --- Retrovirus Infections --- Infection, Retroviridae --- Infection, Retrovirus --- Infection, XMRV --- Infections, XMRV --- Retroviridae Infection --- Retrovirus Infection --- XMRV Infections --- Xenotropic MuLV related Virus Infection --- Xenotropic Murine Leukemia Virus related Virus Infection --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Leukemogenic Viruses --- Leukoviruses --- Oncornaviruses --- Oncovirinae --- Oncoviruses --- Oncoviruses, Type C --- RNA Tumor Viruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Computer Simulation --- Systems Theory --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Genetic Vectors --- Microbiology --- Diseases of Immune System --- Immune Diseases --- Immunological Diseases --- Immune Disorders --- Immune System Disorders --- Immunologic Diseases --- Disease, Immune --- Disease, Immune System --- Disease, Immunologic --- Disease, Immunological --- Disorder, Immune System --- Immune Disease --- Immune Disorder --- Immune System Disease --- Immune System Disorder --- Immunologic Disease --- Immunological Disease --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- deficiency --- Disease Models, Animal. --- Retroviridae Infections - veterinary --- Immunologic Deficiency Syndromes - veterinary --- Neoplasms - veterinary

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Our understanding of addiction and how it is treated has advanced remarkably over the past decades, and much of the progress is related directly to animal research. This is true for both the behavioural aspects of drug use as well as the biological underpinnings of the disorder. In Animal Models of Drug Addiction, experts in the field provide an up-to-date review of complex behavioural paradigms that model different stages of this disorder and explain how each test is used to effectively replicate the progression of drug addiction. This detailed and practical book begins with the most common laboratory measures of addiction in animals, including intracranial self-stimulation (ICSS), drug self-administration, place conditioning, and sensitization. Later chapters describe how these paradigms are used to model the progression of drug addiction, providing insight into the clinical symptomatology of addiction from acquisition of drug use through compulsive drug taking to withdrawal and relapse. Written for the popular Neuromethods series, the contributions offer both methodological detail and a theoretical perspective, appealing to readers familiar with preclinical research on drug addiction as well as those who are newcomers to the field. Cutting-edge and authoritative, Animal Models of Drug Addiction will serve as a basis for future vital research that links the bench to the bedside in the crucial treatment of drug addiction.

Drug abuse --- Alcoholism --- Psychotropic Drugs --- Substance-Related Disorders --- Feeding and Eating Disorders. --- Models, Animal. --- Self Stimulation --- Animal models. --- pharmacology. --- psychology. --- physiology. --- Biological Science Disciplines --- Central Nervous System Agents --- Mental Disorders --- Investigative Techniques --- Diseases --- Behavioral Sciences --- Behavior --- Psychophysiology --- Natural Science Disciplines --- Psychological Phenomena and Processes --- Therapeutic Uses --- Psychiatry and Psychology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Behavioral Disciplines and Activities --- Behavior and Behavior Mechanisms --- Disciplines and Occupations --- Pharmacologic Actions --- Psychology --- Models, Animal --- Pharmacology --- Physiology --- Eating Disorders --- Chemical Actions and Uses --- Chemicals and Drugs --- Medicine --- Psychiatry --- Health & Biological Sciences --- Neurology --- Substance Abuse Disorders --- Animal models --- Pharmacologies --- Pharmaceutical Preparations --- Substance Addiction --- Drug Abuse --- Drug Addiction --- Drug Dependence --- Drug Habituation --- Drug Use Disorders --- Organic Mental Disorders, Substance-Induced --- Substance Abuse --- Substance Dependence --- Substance Use Disorders --- Abuse, Drug --- Abuse, Substance --- Abuses, Substance --- Addiction, Drug --- Addiction, Substance --- Dependence, Drug --- Dependence, Substance --- Disorder, Drug Use --- Disorder, Substance Use --- Drug Use Disorder --- Habituation, Drug --- Organic Mental Disorders, Substance Induced --- Substance Abuses --- Substance Use Disorder --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Psychoactive Drugs --- Psychoactive Agents --- Psychopharmaceuticals --- Agents, Psychoactive --- Drugs, Psychoactive --- Drugs, Psychotropic --- Factors, Psychological --- Psychological Factors --- Psychological Side Effects --- Psychologists --- Psychosocial Factors --- Side Effects, Psychological --- Factor, Psychological --- Factor, Psychosocial --- Factors, Psychosocial --- Psychological Factor --- Psychological Side Effect --- Psychologist --- Psychosocial Factor --- Side Effect, Psychological --- Eating and Feeding Disorders --- Feeding Disorders --- Appetite Disorders --- Appetite Disorder --- Disorder, Eating --- Disorder, Feeding --- Disorders, Eating --- Disorders, Feeding --- Eating Disorder --- Feeding Disorder --- Self Stimulations --- Stimulation, Self --- Stimulations, Self --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Psychologic Processes and Principles --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Acceptance Process --- Acceptance Processes --- Behaviors --- Process, Acceptance --- Processes, Acceptance --- Proxemics --- Behavioral Science --- Proxemic --- Science, Behavioral --- Sciences, Behavioral --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Behavior Disorders --- Diagnosis, Psychiatric --- Mental Disorders, Severe --- Psychiatric Diagnosis --- Disorder, Mental --- Disorder, Severe Mental --- Disorders, Behavior --- Disorders, Mental --- Disorders, Severe Mental --- Mental Disorder --- Mental Disorder, Severe --- Severe Mental Disorder --- Severe Mental Disorders --- Central Nervous System Drugs --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- pharmacology --- Neurosciences. --- Psychiatry. --- Laboratory animals. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Feeding and Eating Disorders --- psychology