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Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.
Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Cardiovascular medicine
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Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders
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Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders
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This book presents a multispecialty and multidisciplinary approach on Amyloidosis and Fabry disease. These two “rare” diseases are underdiagnosed and have systemic peculiarities that should be emphasized for diagnosis. In both cases, early diagnosis is important for initiating treatment sooner, achieving better prognosis, and improving patients’ quality of life. The history of these patients, in general, involves a long journey among health professionals to obtain a diagnosis. Even after a patient is diagnosed, there are still difficulties in understanding these complex diseases, managing complications, and defining specific treatment. Therefore, this work will be a valuable resource for many healthcare professionals, including physicians of various specialties, nurses, physiotherapists, and medical students. It will also be of interest to patients who would like to understand Amyloidosis and Fabry disease. The content will give healthcare professionals a clinical perspective and provide insights on proper care. Readers will be able to recognize the symptoms related to each disease and will be guided during diagnosis and treatment. Chapters include an overview on clinical course, and will address neurological, ophthalmological, dermatological, gastrointestinal, hematological and cardiology manifestations, orthopedic care, mutations, expressiveness according to epigenetics and multidisciplinary treatment. Chapter authors from around the world have contributed sharing their experience in managing these diseases.
Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders
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Amyloidosis is a benign, slowly progressive condition characterized by the presence of extracellular fibrillar proteins in various organs and tissues. It has systemic or localized forms. Both systemic and localized amyloidosis have been a point of interest for many researchers and there have been a growing number of case reports in the literature for the last decade. The aim of this book is to help the reader become familiar with the presentation, diagnosis and treatment modalities of systemic and localized amyloidosis of specific organs or systems and also cover the latest advancements in therapy.
Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Infectious & contagious diseases
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Amyloidoses are a heterogeneous group of diverse etiology diseases. They are characterized by an endogenous production of abnormal proteins called amyloid proteins, which are not hydrosoluble, form depots in various organs and tissue of animals and humans and cause dysfunctions. Despite many decades of research, the origin of the pathogenesis and the molecular determinants involved in amyloid diseases has remained elusive. At present, there is not an effective treatment to prevent protein misfolding in these amyloid diseases. The aim of this book is to present an overview of different aspects of amyloidoses from basic mechanisms and diagnosis to latest advancements in treatment.
Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Infectious & contagious diseases
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Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?
Amyloidosis --- Diagnosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Medicine --- Endocrinology --- Health Sciences
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Amyloidosis is an uncommon disorder characterized by the deposition of extracellular amyloid proteins in tissues. Significant advancement has been made recently, which not only provides insight in to the pathophysiology of the disease but also helps to discover new therapies to fight the deadly disease. If accurate diagnosis and typing are made early, effective or even curative therapies are available. Unfortunately, because of the rarity of the disease and its protean clinical manifestations, patients may be misdiagnosed, especially at early stage of the disease, and this could lead to missed opportunities to effective therapy. The aim of the book is to help readers become familiar with the clinical presentation of amyloidosis and to review the latest diagnostic and therapeutic development.
Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Infectious & contagious diseases
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Amyloid --- Amyloidosis --- periodicals. --- Amyloid. --- Amyloidosis. --- Amyloid degeneration --- Amyloidoses --- Amyloid Fibrils --- Amyloid Substance --- Fibrils, Amyloid --- Substance, Amyloid --- Plaque, Amyloid --- Glycoproteins --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Amyloid Fibril --- Fibril, Amyloid --- Amiloïdosi
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The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Medicine & Public Health. --- Pathology. --- Nephrology. --- Oncology. --- Medicine. --- Médecine --- Néphrologie --- Cancérologie --- Pathologie --- Amyloidosis. --- Lymphoproliferative disorders. --- Pathology --- Medicine --- Health & Biological Sciences --- Immunoproliferative disorders --- Lymphoproliferative syndrome --- Amyloid degeneration --- Cell proliferation --- Immunological deficiency syndromes --- Lymphatics --- Lymphomas --- Lymphoproliferative disorders --- Proteins --- Diseases --- Metabolism --- Disorders --- Oncology . --- Tumors --- Internal medicine --- Kidneys --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive
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