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Molecularly imprinted polymers are materials that have voids that are complementary in shape, size, and electronic environment to a specific molecule used for preparation, known as the template. These voids are specific recognition sites that bind the templates preferentially and are used specifically for biomimetic sensors and for solid-phase extraction. Because the specific surface is very important during this process, the use of films and membranes is preferred. This book contains four articles dedicated to sensor application (three research articles and one review) and one research article dedicated to solid-phase extraction.

Technology: general issues --- History of engineering & technology --- Materials science --- sol-gel --- molecularly imprinted films --- bisphenol A --- organosilane monomer --- molecularly imprinted polymer --- optical sensor --- plastic optical fiber --- surface plasmon resonance --- 2-furaldehyde --- vegetable oil --- waste plastic --- polyethylene terephthalate --- electrospinning --- 2-(aminomethyl)pyridine --- adsorption --- copper ion --- nanofibre --- molecularly imprinted layers --- surface polymerization --- electropolymerization --- sol–gel derived techniques --- phase inversion --- electroactive pastes and inks --- amyloid β-42 --- molecularly imprinted polymers --- potentiometric sensor --- Alzheimer biomarker --- n/a --- sol-gel derived techniques

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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.

arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer’s --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer’s disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β --- n/a --- Alzheimer's --- Alzheimer's disease

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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.

Research & information: general --- arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer's --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer's disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β

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This book focuses on the recent advancements in both fundamental and clinical research, focusing on identifying, developing, and applying new and improved biological markers for specific neurologic disorders in the future. The original research work and review articles published here highlight some unique mechanisms underlying the most prevalent pathophysiological conditions affecting human health. Other areas covered in the book include emerging treatment options and correct diagnoses using different biochemical and imaging techniques.

Medicine --- Alzheimer’s disease --- amyloid beta --- hippocampus --- Kir channels --- K+ channels --- glioblastoma multiforme --- low-grade glioma --- astrocytoma --- recurrence --- multifocal growth --- mRNA expression --- MPS1 --- TTK --- therapy --- EDTA chelation therapy --- neurodegenerative diseases --- metal detoxification --- reactive oxygen species (ROS) --- neuroinflammation --- neurodegeneration --- cognitive dysfunction --- neurofibrillary tangles --- diagnosis methods --- biomarkers --- perinatal stress --- NURR1 --- inflammation --- late-onset diseases --- early life --- artificial neural network --- deep learning --- Parkinson’s disease --- atypical parkinsonian syndrome --- dopamine transporter SPECT --- β-Amyloid --- calpain --- Collapsin Response Mediator Protein-2 --- human-neuroblastoma SH-SY5Y cells --- Somatostatin-14 --- somatostatin receptor --- brain injury --- quinpirole --- dopamine D2 receptors --- glial cell --- autophagy --- mitophagy --- multiple sclerosis --- biomarker --- neurons --- astrocytes --- Alzheimer’s and Parkinson’s diseases --- fluid and imaging biomarkers --- amyloid-β and tau --- miRNA --- extracellular vesicles --- exosomes and ectosomes --- PET --- radiotracers --- radiolabeled molecules --- n/a --- Alzheimer's disease --- Parkinson's disease --- Alzheimer's and Parkinson's diseases

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This Special Issue provides recent advances in the use of plants for therapeutic purposes. This Special Issue collected the plants, including leaf, fruit, and others. This Special Issue's targets were crude plant extract and active principle purified from the plant. This Special Issue prompted researchers to provide each plant discovery. We are pleased to include in this Special Issue the screened Mexican plants and the halophytic plants growing in central Saudi Arabia, and so on. As a result, we have sparked scientists' interest in studying the plant for therapeutic purposes. This field necessitates network pharmacology analysis and machine-aided learning. Many disorders resistant to modern medication are looking for active principles isolated from the plants all over the world.

Medicine --- Pharmacology --- safflower --- hydroxysafflor yellow A --- safflower yellow A --- flavonoid --- platelet aggregation --- vescalagin --- methylglyoxal --- inflammation --- antioxidant --- insulin secretion --- traditional medicine --- hypoglycemic plants --- Eryngium longifolium --- Alsophila firma --- glucose 6-phosphatase --- fructose 1,6-bisphosphatase --- Lycium shawii --- Anabasis articulata --- Rumex vesicarius --- Zilla spinosa --- anticancer --- antimicrobial --- biogenetic interrelationship --- flavonoid contents --- trace elements --- human tumor cell lines --- cytotoxic effect --- plant extracts --- Acalypha monostachya --- Lindera obtusiloba --- apolipoprotein E-deficient mice --- atherosclerosis --- endothelium --- black bean soybean sauce --- by-product --- functional supplements --- Moringa oleifera --- anti-aging --- fibrosis --- kidney disease --- Gan-Mai-Da-Zao --- depression --- brain-derived neurotrophic factor --- serotonin transporter --- unpredictable chronic mild stress --- Acalypha arvensis --- ellagitannin --- corilagin --- Staphylococcus aureus --- flavonoids --- antibacterial --- Alzheimer’s disease --- amyloid β --- immunomagnetic reduction --- Drosophila melanogaster --- water extract of fermented rice bran --- non-alcoholic fatty liver disease --- high-fat diet --- aged rat --- Salvia haematodes --- rapid solid–liquid dynamic extraction (RSLDE) --- extractor Naviglio® --- Soxhlet apparatus --- medium pressure liquid chromatography (MPLC) --- antioxidant potential --- Inga jinicuil --- phytochemical profile --- HPLC-PDA --- GC-MS --- anti-inflammatory --- fast dissolving films --- yeast β-glucan --- bilberry juice --- diabetes --- herbal medicine --- bioactive derivative --- triple negative breast cancer --- Wnt/β-catenin --- anti-cancer --- n/a --- Alzheimer's disease --- rapid solid-liquid dynamic extraction (RSLDE)