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Book
Synthetic DNA and RNA Programming
Authors: ---
ISBN: 3039217356 3039217348 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease.

Keywords

growth effect --- lysine acetylation --- Escherichia coli --- posttranslational modification --- class II aminoacyl-tRNA synthetase --- amber stop codon suppression --- genetic code expansion --- yeasts --- phosphoseryl-tRNA synthetase --- M. jannaschii orthogonal pair --- gene ontology --- selenocysteine --- genetic firewall --- indirect tRNA aminoacylation --- tRNA editing --- unnatural nucleotides --- reverse polymerization --- RNA metabolism --- genome editing --- tRNA --- tRNASer --- alternative amino acid and nucleotide repertoires --- biocontainment --- fluorescent reporter --- optogenetics --- tRNASep --- GluRS-like --- genetic isolation --- live cell imaging --- alternative core cellular chemistries --- fluorescence-based screen --- phosphoinositide dependent kinase 1 --- synthetic biology --- mistranslation --- tRNA repair --- synthetic life --- CUG-Ser --- unnatural amino acids --- recombinant protein production --- biopharmaceuticals --- protein modification --- functional conservation --- branched-chain amino acids --- alanyl-tRNA synthetase --- release factor 1 --- cyclic peptides --- AspRS --- xenobiology --- DNA delivery --- gene overexpression --- non-canonical amino acids --- ASKA collection --- protein kinase B --- codon bias --- microRNA quantification --- anticodon --- small molecule drug screening --- mRNA display --- genetic tools --- protein engineering --- misacylation --- transfer RNA --- Metschnikowia --- genome synthesis --- expanded genetic code --- yeast two hybrid --- orthogonal central dogma of molecular biology --- microRNA --- genome engineering

Protein biosynthesis
Authors: ---
ISBN: 0199630402 9780199630400 Year: 1992 Publisher: Oxford: IRL press,

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This concise volume provides a clear, accessible introduction to the mechanisms and processes of protein synthesis. It includes a useful overview of basic theory, descriptions of the structure and function of the ribosome, and an account of the regulation of protein synthesis. As a well-structured summary of important principles, this work will be useful to experienced researchers as well as students. There is no comparable text available that covers the field of protein synthesis in such a cohesive manner.

Keywords

Proteins --- Amino Acyl-tRNA Synthetases --- Ribosomes --- RNA, messenger --- RNA, Transfer --- AMINO ACIDS --- Synthesis --- biosynthesis --- Amino Acids. --- Amino Acyl-tRNA Synthetases. --- Protein Biosynthesis. --- Ribosomes. --- RNA, Messenger. --- RNA, Transfer. --- 577.217 --- 577.122 --- -#ABIB:aimm --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- RNA, Transfer, Suppressor --- Transfer RNA, Suppressor --- Suppressor Transfer RNA --- Transfer RNA --- tRNA --- RNA, Suppressor Transfer --- Non-Polyadenylated mRNA --- Poly(A) RNA --- Polyadenylated mRNA --- Messenger RNA --- Messenger RNA, Polyadenylated --- Poly(A) Tail --- Poly(A)+ RNA --- Poly(A)+ mRNA --- RNA, Messenger, Polyadenylated --- RNA, Polyadenylated --- mRNA --- mRNA, Non-Polyadenylated --- mRNA, Polyadenylated --- Non Polyadenylated mRNA --- Polyadenylated Messenger RNA --- Polyadenylated RNA --- RNA, Polyadenylated Messenger --- mRNA, Non Polyadenylated --- Ribosome --- Protein Biosynthesis, Ribosomal --- Protein Synthesis, Ribosomal --- Ribosomal Peptide Biosynthesis --- mRNA Translation --- Genetic Translation --- Peptide Biosynthesis, Ribosomal --- Protein Translation --- Translation, Genetic --- Biosynthesis, Protein --- Biosynthesis, Ribosomal Peptide --- Biosynthesis, Ribosomal Protein --- Genetic Translations --- Ribosomal Protein Biosynthesis --- Ribosomal Protein Synthesis --- Synthesis, Ribosomal Protein --- Translation, Protein --- Translation, mRNA --- mRNA Translations --- Genetic Code --- Peptide Biosynthesis --- Codon, Initiator --- Codon, Terminator --- Acids, Amino --- Realization of inheritance information. Translation. Molecular mechanisms of protein biosynthesis --- Protein metabolism --- Amino Acyl T RNA Synthetases. --- Synthesis. --- biosynthesis. --- 577.122 Protein metabolism --- 577.217 Realization of inheritance information. Translation. Molecular mechanisms of protein biosynthesis --- Amino acids. --- Amino acyl t rna synthetases. --- Rna, messenger. --- Rna, transfer. --- Biosynthesis. --- Amino Acids --- Protein Biosynthesis --- RNA, Messenger --- #ABIB:aimm --- Aminoacyl Transfer RNA Synthetase --- Aminoacyl-tRNA Synthetase --- Transfer RNA Synthetase --- tRNA Synthetase --- Amino Acyl T RNA Synthetases --- Amino Acyl-tRNA Ligases --- Acyl-tRNA Ligases, Amino --- Acyl-tRNA Synthetases, Amino --- Amino Acyl tRNA Ligases --- Amino Acyl tRNA Synthetases --- Aminoacyl tRNA Synthetase --- Ligases, Amino Acyl-tRNA --- RNA Synthetase, Transfer --- Synthetase, Aminoacyl-tRNA --- Synthetase, Transfer RNA --- Synthetase, tRNA --- Synthetases, Amino Acyl-tRNA --- Transfer RNA Aminoacylation --- Protein biosynthesis --- Protein synthesis --- Metabolism --- Amino Acid --- Acid, Amino --- Proteins - Synthesis --- Proteins - biosynthesis


Book
The Origin and Early Evolution of Life : Prebiotic Systems Chemistry Perspective
Authors: ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

What is life? How, where, and when did life arise? These questions have remained most fascinating over the last hundred years. Systems chemistry is the way to go to better understand this problem and to try and answer the unsolved question regarding the origin of Life. Self-organization, thanks to the role of lipid boundaries, made possible the rise of protocells. The role of these boundaries is to separate and co-locate micro-environments, and make them spatially distinct; to protect and keep them at defined concentrations; and to enable a multitude of often competing and interfering biochemical reactions to occur simultaneously. The aim of this Special Issue is to summarize the latest discoveries in the field of the prebiotic chemistry of biomolecules, self-organization, protocells and the origin of life. In recent years, thousands of excellent reviews and articles have appeared in the literature and some breakthroughs have already been achieved. However, a great deal of work remains to be carried out. Beyond the borders of the traditional domains of scientific activity, the multidisciplinary character of the present Special Issue leaves space for anyone to creatively contribute to any aspect of these and related relevant topics. We hope that the presented works will be stimulating for a new generation of scientists that are taking their first steps in this fascinating field.

Keywords

origin of life --- peptidyl-transferase center --- pseudo-symmetry --- proto-ribosome --- SymR --- emergence of biological systems --- RNA ligation --- dimerization --- standard genetic codes --- codon assignment --- tRNA --- aminoacyl-tRNA synthetase classes --- thiophene --- acetylene --- transition metal sulfides --- hydrothermal conditions --- early metabolism --- origin-of-life --- prebiotic chemistry --- protein–monosaccharide recognition --- protein–monosaccharide interactions --- FRET analysis --- glycocodon theory --- glucose oxidase --- Mars --- prebiotic chemical evolution --- early Earth --- astrobiology --- CHNOPS --- transition elements --- sample return --- exoplanets --- complex organic molecules --- astrochemistry --- interstellar medium --- molecular ices --- solid state --- protoplanetary disks --- star forming regions --- comets --- vesicles --- division --- urea–urease enzymatic reaction --- bending modulus --- budding --- ADE theory --- dynamic kinetic stability --- cognition --- chemical evolution --- systems chemistry --- metabolism --- network expansion simulation --- temperature --- thermodynamics --- protocell --- compartment --- solid interface --- lipid --- polymerization --- cyclic nucleotides --- autocatalytic set --- osmotic pressure --- cell division --- lipid membrane --- bistable reaction system --- template-directed RNA synthesis --- origin of genetic code --- time order of canonical amino acids --- proto-metabolism --- chirogenesis --- quartz --- amino acids --- radiation damage --- GC×GC-TOFMS --- origins of life --- prebiotic membranes --- protoamphiphiles --- metal ions --- hot springs --- N-acyl amino acid --- analogue conditions --- viroids --- ribozyviruses --- primordial replicators --- ribozymes --- bilayer structure --- molecular dynamics --- aggregation process --- selection --- evolution --- Fenton chemistry --- reduced phosphorus --- pyrophosphate --- chemical complexity --- minerals --- schreibersite --- olivine --- serpentinite --- ulexite --- n/a --- protein-monosaccharide recognition --- protein-monosaccharide interactions --- urea-urease enzymatic reaction


Book
The Origin and Early Evolution of Life : Prebiotic Systems Chemistry Perspective
Authors: ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

What is life? How, where, and when did life arise? These questions have remained most fascinating over the last hundred years. Systems chemistry is the way to go to better understand this problem and to try and answer the unsolved question regarding the origin of Life. Self-organization, thanks to the role of lipid boundaries, made possible the rise of protocells. The role of these boundaries is to separate and co-locate micro-environments, and make them spatially distinct; to protect and keep them at defined concentrations; and to enable a multitude of often competing and interfering biochemical reactions to occur simultaneously. The aim of this Special Issue is to summarize the latest discoveries in the field of the prebiotic chemistry of biomolecules, self-organization, protocells and the origin of life. In recent years, thousands of excellent reviews and articles have appeared in the literature and some breakthroughs have already been achieved. However, a great deal of work remains to be carried out. Beyond the borders of the traditional domains of scientific activity, the multidisciplinary character of the present Special Issue leaves space for anyone to creatively contribute to any aspect of these and related relevant topics. We hope that the presented works will be stimulating for a new generation of scientists that are taking their first steps in this fascinating field.

Keywords

Research & information: general --- Biology, life sciences --- origin of life --- peptidyl-transferase center --- pseudo-symmetry --- proto-ribosome --- SymR --- emergence of biological systems --- RNA ligation --- dimerization --- standard genetic codes --- codon assignment --- tRNA --- aminoacyl-tRNA synthetase classes --- thiophene --- acetylene --- transition metal sulfides --- hydrothermal conditions --- early metabolism --- origin-of-life --- prebiotic chemistry --- protein-monosaccharide recognition --- protein-monosaccharide interactions --- FRET analysis --- glycocodon theory --- glucose oxidase --- Mars --- prebiotic chemical evolution --- early Earth --- astrobiology --- CHNOPS --- transition elements --- sample return --- exoplanets --- complex organic molecules --- astrochemistry --- interstellar medium --- molecular ices --- solid state --- protoplanetary disks --- star forming regions --- comets --- vesicles --- division --- urea-urease enzymatic reaction --- bending modulus --- budding --- ADE theory --- dynamic kinetic stability --- cognition --- chemical evolution --- systems chemistry --- metabolism --- network expansion simulation --- temperature --- thermodynamics --- protocell --- compartment --- solid interface --- lipid --- polymerization --- cyclic nucleotides --- autocatalytic set --- osmotic pressure --- cell division --- lipid membrane --- bistable reaction system --- template-directed RNA synthesis --- origin of genetic code --- time order of canonical amino acids --- proto-metabolism --- chirogenesis --- quartz --- amino acids --- radiation damage --- GC×GC-TOFMS --- origins of life --- prebiotic membranes --- protoamphiphiles --- metal ions --- hot springs --- N-acyl amino acid --- analogue conditions --- viroids --- ribozyviruses --- primordial replicators --- ribozymes --- bilayer structure --- molecular dynamics --- aggregation process --- selection --- evolution --- Fenton chemistry --- reduced phosphorus --- pyrophosphate --- chemical complexity --- minerals --- schreibersite --- olivine --- serpentinite --- ulexite

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