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Our current knowledge of the role of macroglia in the physiology of the nervous system has been shaped on by both the established role of oligodendrocytes and Schwann cells in the propagation of the action potential and by the concept of the tripartite synapse. In both cases, integral membrane proteins such as receptors and transporters are crucial for the proper function of these cells. This book is an extensive review of the contribution of glial membrane transporters.  Model transporters are analysed in terms of their structure, distribution and involvement in major functions and/or pathologies of the nervous system. It is important to note that a particular emphasis has been placed in the rather unexplored signalling properties of glial transporters. Likewise, strategies toward the design of novel compounds that target membrane transporters are discussed. Different points of view of the involvement and contribution of glial transporters are presented in this volume, and the contrast of these interpretations invites the readers to broaden their interest of membrane transporters beyond the chapters of this book. No intention was made to provide a certain order to the chapters of the book; in fact any of them can be read independently. We want to express our appreciation to the contributors for their enthusiasm in the preparation of their excellent chapters that will certainly provide a fresh perspective of the exponential accumulation of knowledge that has been published in the last few years and unequivocally changing the concept of glial physiology. It is our hope that this book provides a major input to the fascinating field of membrane transporters as fundamental proteins for the establishment of a better understanding of glia-neuron interactions.  .

GABA. --- Glutamic acid. --- Glutamate --- Gamma-aminobutyric acid --- Medicine. --- Neurosciences. --- Neurobiology. --- Biomedicine. --- Excitatory amino acids --- Umami (Taste) --- Amino acid neurotransmitters --- Aminobutyric acid --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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Highlighting the current developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease. It is of topical importance because these neurotransmitters are essential for brain function and therapy of diseases such as anxiety disorders, insomnias, epilepsy, depression, spasticity, and memory deficits. Distinguished scientists at the forefront of research contributed reviews on the role of these transmitters in governing neuronal networks, their signalling pathways, their receptors, the pharmacology of GABA A- and GABA B- and GABA C-receptors as well as of GABA- and glycine-transporters, and their role in disease. The volume serves as reference for pharmacologists/toxicologists, neuroscientists, neurologists and psychiatrists.

Amino acid neurotransmitters. --- Gaba --- Glycine --- Physiological effect. --- Receptors. --- Acides aminés [Neurotransmetteurs des ] --- Amino acid neurotransmitters --- Aminozuur-neurotransmitters --- Neurotransmetteurs des acides aminés --- Neurotransmitters [Aminozuur-] --- GABA --- Physiological effect --- Receptors --- Pharmacology. --- Psychopharmacology. --- Neurology . --- Neurosciences. --- Psychiatry. --- Human physiology. --- Pharmacology/Toxicology. --- Neurology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Medicine --- Neuropsychiatry --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Drug effects --- Medical pharmacology --- Chemicals --- Pharmacy --- Diseases --- Psychotropic effects

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With contributions by numerous experts.

Acides aminés [Excitation d' ] --- Aminozuren [Opwekkende ] --- Excitation d'acides aminés --- Excitatory amino acids --- Glutamaatreceptoren --- Glutamate [Récepteurs de ] --- Opwekkende aminozuren --- Receptoren [Glutamaat] --- Receptors [Glutamate ] --- Récepteurs de glutamate --- Glutamic acid --- Receptors --- Neurology . --- Pharmacology. --- Neurosciences. --- Molecular biology. --- Human physiology. --- Biochemistry. --- Neurology. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Human Physiology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Human biology --- Physiology --- Human body --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Neuropsychiatry --- Composition --- Physiological effect --- Diseases --- Receptors, Glutamate. --- Excitatory amino acids. --- Receptors. --- Glutamate --- Umami (Taste) --- Amino acid neurotransmitters