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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

posttranscriptional regulation --- RNA processing --- RNA Stability --- RNA structure --- Alternative Splicing --- small RNAs --- MicroRNAs --- long non-coding RNAs --- tran

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Botany & plant sciences --- posttranscriptional regulation --- RNA processing --- RNA Stability --- RNA structure --- Alternative Splicing --- small RNAs --- MicroRNAs --- long non-coding RNAs --- tran --- posttranscriptional regulation --- RNA processing --- RNA Stability --- RNA structure --- Alternative Splicing --- small RNAs --- MicroRNAs --- long non-coding RNAs --- tran

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Gibberellins (GA) and abscisic acid (ABA) are two phytohormones that regulate, in an antagonistic way, plant growth as well as several developmental processes from seed maturation and germination to flowering time, through hypocotyl elongation and root growth. In general, ABA and GA inhibit and promote, respectively, cell elongation and growth. Consequently, this mutual antagonism between GA and ABA governs many developmental decisions in plants.In addition to its role as a growth and development modulator, ABA is primarily known for being a major player in the response and adaptation of plants to diverse abiotic stress conditions, including cold, heat, drought, salinity or flooding. Remarkably, different works have also recently pointed to a function for GA in the control of some biological processes in response to stress.The selection of research and review papers of this book, mostly focused on ABA, covers a wide range of topics related to the most recent advances in the molecular mechanisms of ABA and GA functions in plants.

Picea wilsonii --- transcription factor --- PwNAC11 --- drought stress --- ABA signaling --- Arabidopsis --- GA signaling --- AGB1 --- MYB62 --- protein interaction --- ABA deficiency --- fruit dehydration --- gene expression --- hormone application --- Pinalate --- postharvest --- upstream open reading frame --- translation --- abscisic acid --- protein kinase WNK8 --- ABA --- drought --- metabolites --- signaling --- crop breeding --- carotenoid --- CCD --- NCED --- poplar --- gibberellin (GA) --- abscisic acid (ABA) --- seed development --- seed maturation --- alternative splicing --- abiotic stress responses --- plant development --- root and tuber crops --- stem/root tuber development --- GA --- gibberellic acid --- arabidopsis --- ABI5 --- ABI5-binding proteins (AFPs) --- DELLA proteins --- SLEEPY1 --- germination --- dormancy --- storage proteins --- n/a --- Research. --- Biology.

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This book is a collection of eight articles, of which seven are reviews and one is a research paper, that together form a Special Issue that describes the roles that long noncoding RNAs (lncRNA) play in gene regulation at a post-transcriptional level.

Research & information: general --- Biology, life sciences --- long non-coding RNA 1 --- RNA binding protein 2 --- post-transcriptional regulation --- long non-coding RNA --- mRNA stability --- RNA binding protein --- microRNA --- gene expression --- long noncoding RNA --- target mimicry --- alternative splicing --- protein re-localization --- translation promotion --- post-translational modification --- double-stranded RNA (dsRNA) --- innate immunity --- repetitive DNA elements (RE) --- antisense transcript --- non-coding RNAs --- long non-coding RNAs --- ncRNAs --- translation --- cancer --- lncRNA --- post-transcription --- RNA-binding --- ribonucleoprotein --- RNAi --- interactome --- prediction --- database --- CLIP --- splicing factors --- miRNAs --- lncRNAs --- ceRNAs --- mTOR pathway --- long non-coding RNA 1 --- RNA binding protein 2 --- post-transcriptional regulation --- long non-coding RNA --- mRNA stability --- RNA binding protein --- microRNA --- gene expression --- long noncoding RNA --- target mimicry --- alternative splicing --- protein re-localization --- translation promotion --- post-translational modification --- double-stranded RNA (dsRNA) --- innate immunity --- repetitive DNA elements (RE) --- antisense transcript --- non-coding RNAs --- long non-coding RNAs --- ncRNAs --- translation --- cancer --- lncRNA --- post-transcription --- RNA-binding --- ribonucleoprotein --- RNAi --- interactome --- prediction --- database --- CLIP --- splicing factors --- miRNAs --- lncRNAs --- ceRNAs --- mTOR pathway

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Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.

Medicine --- SCN5A --- cardiac sodium channel --- cardiac channelopathy --- dilated cardiomyopathy --- precision medicine --- arrhythmias --- atrial fibrillation --- cardiomyopathy --- heart failure --- supraventricular arrhythmia --- systolic dysfunction --- tachycardiomyopathy --- ventricular arrhythmia --- left atrial strain --- cardiac resynchronization therapy --- muscular dystrophy --- calcium --- heart --- gene therapy --- phospholamban --- Serca2a --- mdx --- oxidative stress --- membrane stabilization --- left ventricular noncompaction --- congenital heart disease --- congestive heart failure --- non-ischemic cardiomyopathy --- genetics --- desmin --- mitochondrial dysfunction --- myopathy --- whole exome sequencing --- laminopathy --- LMNA --- biomarkers --- troponin T --- NT-proBNP --- malignant ventricular arrhythmia --- arrhythmic risk stratification --- DNA methylation --- alternative splicing --- epigenetics --- nonischemic dilated cardiomyopathy --- cardiac magnetic resonance imaging --- late gadolinium enhancement --- long axis strain --- left ventricle sphericity index --- major adverse cardiovascular events --- sex differences --- left ventricular reverse remodelling --- long-term outcomes --- left ventricle non-compaction cardiomyopathy --- cardiac magnetic resonance --- titin --- RNA binding motif protein 20 (RBM20) --- sarcomere --- diastolic dysfunction --- phosphorylation --- non-sense mRNA decay --- mammalian target of rapamycin (mTOR) complex-1 --- duchenne muscular distrophy --- SCN5A --- cardiac sodium channel --- cardiac channelopathy --- dilated cardiomyopathy --- precision medicine --- arrhythmias --- atrial fibrillation --- cardiomyopathy --- heart failure --- supraventricular arrhythmia --- systolic dysfunction --- tachycardiomyopathy --- ventricular arrhythmia --- left atrial strain --- cardiac resynchronization therapy --- muscular dystrophy --- calcium --- heart --- gene therapy --- phospholamban --- Serca2a --- mdx --- oxidative stress --- membrane stabilization --- left ventricular noncompaction --- congenital heart disease --- congestive heart failure --- non-ischemic cardiomyopathy --- genetics --- desmin --- mitochondrial dysfunction --- myopathy --- whole exome sequencing --- laminopathy --- LMNA --- biomarkers --- troponin T --- NT-proBNP --- malignant ventricular arrhythmia --- arrhythmic risk stratification --- DNA methylation --- alternative splicing --- epigenetics --- nonischemic dilated cardiomyopathy --- cardiac magnetic resonance imaging --- late gadolinium enhancement --- long axis strain --- left ventricle sphericity index --- major adverse cardiovascular events --- sex differences --- left ventricular reverse remodelling --- long-term outcomes --- left ventricle non-compaction cardiomyopathy --- cardiac magnetic resonance --- titin --- RNA binding motif protein 20 (RBM20) --- sarcomere --- diastolic dysfunction --- phosphorylation --- non-sense mRNA decay --- mammalian target of rapamycin (mTOR) complex-1 --- duchenne muscular distrophy