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COMPLEMENT, physiology --- Complement (Immunology) --- Complement System Proteins --- #ABIB:aimm --- physiology. --- Complement (Immunology). --- Alexin --- Complements (Immunity) --- Blood proteins --- physiology

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The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies.Key Features* Includes the cDNA sequences, marked with in

Complement (Immunology) --- Immunology. --- Immunobiology --- Life sciences --- Serology --- Alexin --- Complements (Immunity) --- Blood proteins --- C-reactive protein --- Complement --- Complement activation --- Receptors, cell surface --- Serine proteinases --- Complement (Immunology).

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Blood --- Coagulation --- Fibrinolysis --- Complement (Immunology) --- 612.12 --- Bloedstolling --- Complement systeem --- Fibrinolyse --- Thrombolytic therapy --- Alexin --- Complements (Immunity) --- Blood proteins --- Blood coagulation --- Clotting of blood --- Coagulation of blood --- Hemostasis --- Anticoagulants (Medicine) --- Coagulase --- Clotting

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It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.

Kidneys --- Complement (Immunology) --- Diseases --- Etiology. --- Alexin --- Complements (Immunity) --- Blood proteins --- Abdomen --- Urinary organs --- Nephrology --- Immunology. --- Cytology. --- Nephrology. --- Human physiology. --- Internal medicine. --- Microbiology. --- Cell Biology. --- Human Physiology. --- Internal Medicine. --- Medical Microbiology. --- Internal medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Microorganisms --- Medicine, Internal --- Medicine --- Human biology --- Medical sciences --- Physiology --- Human body --- Cell biology. --- Medical microbiology.

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Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that molecules involved in innate immunity exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the 4th International Conference on Innate Immunity (June 4 - 9, 2006), in Corfu, Greece to discuss recent advances in this fast evolving field. This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.

Natural immunity --- Killer cells --- Complement (Immunology) --- Alexin --- Complements (Immunity) --- Blood proteins --- K cells --- Natural killer cells --- NK cells --- Immunocompetent cells --- Cell-mediated cytotoxicity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Immunology. --- Microbiology. --- Emerging infectious diseases. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Infectious diseases.