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Adrenoleukodystrophy --- Peroxisomal disorders --- Cerebral Sclerosis, Diffuse --- Metabolism, Inborn errors --- Microbodies --- Congresses --- congresses --- Metabolism, Inborn Errors --- Congresses. --- congresses. --- Diffuse Cerebral Sclerosis of Schilder
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Peroxisomes --- Peroxisomal disorders --- Peroxisomal Disorders. --- Peroxysomes. --- Pathologie peroxysomale. --- Peroxisomal disorders. --- Peroxisomes. --- Metabolism. --- Molecular Biology. --- Peroxidosomes --- Peroxysoma --- Adrenoleukodystrophy, Autosomal Neonatal Form --- Adrenoleukodystrophy, Autosomal, Neonatal Form --- Hyperpipecolatemia --- Neonatal Adrenoleukodystrophy --- Peroxisomal Dysfunction, General --- Peroxisomal Dysfunction, Multiple --- Peroxisomal Dysfunction, Single --- Adrenoleukodystrophy, Neonatal --- Hyperpipecolic Acidemia --- Acidemia, Hyperpipecolic --- Acidemias, Hyperpipecolic --- Adrenoleukodystrophies, Neonatal --- Dysfunction, General Peroxisomal --- Dysfunction, Multiple Peroxisomal --- Dysfunction, Single Peroxisomal --- Dysfunctions, General Peroxisomal --- Dysfunctions, Multiple Peroxisomal --- Dysfunctions, Single Peroxisomal --- General Peroxisomal Dysfunction --- General Peroxisomal Dysfunctions --- Hyperpipecolic Acidemias --- Multiple Peroxisomal Dysfunction --- Multiple Peroxisomal Dysfunctions --- Neonatal Adrenoleukodystrophies --- Peroxisomal Disorder --- Peroxisomal Dysfunctions, General --- Peroxisomal Dysfunctions, Multiple --- Peroxisomal Dysfunctions, Single --- Single Peroxisomal Dysfunction --- Single Peroxisomal Dysfunctions --- Peroxisomal diseases --- Peroxysomal disorders --- Diseases --- Peroxisomal Disorders --- PPAR alpha --- PPAR-beta --- PPAR delta --- PPAR gamma --- peroxisome proliferator-activated receptors --- Microbodies --- Central nervous system --- Metabolism, Inborn errors of --- Pediatric neurology --- Human physiology --- Life Sciences --- Biology --- ppar alpha --- ppar-beta --- ppar delta --- ppar gamma --- Peroxysomes --- Pathologie peroxysomale --- Glycosomes --- Glycosome --- Microbody --- Peroxisome Proliferators
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Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer’s disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5′ untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport --- n/a --- Alzheimer's disease --- 5' untranslated region
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Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
Research & information: general --- Biology, life sciences --- ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer's disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5' untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport
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