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Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy. All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy. The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world. The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.
Hematopoietic Stem Cell Transplantation. --- Hematopoietic Stem Cells --- Immunotherapy, Adoptive. --- Neoplasms --- Cellular therapy --- Cell therapy --- Cells --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Adoptive Immunotherapy --- Cellular Immunotherapy, Adoptive --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- physiology. --- therapy. --- Therapeutic use --- transplantation --- Hematopoietic Stem Cell Transplantation --- Immunotherapy, Adoptive --- physiology --- therapy --- Physiology --- Therapy --- CAR T-Cell Therapy --- Chimeric Antigen Receptor Therapy --- CAR T Cell Therapy --- CAR T-Cell Therapies --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Cell biology. --- Molecular biology. --- Oncology . --- Cell Biology. --- Molecular Medicine. --- Oncology. --- Tumors --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell biology --- Cellular biology --- Biology
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Immunotherapy. --- Cancer --- Genetic engineering. --- Treatment. --- T cells. --- Neoplasms --- Receptors, Antigen, T-Cell --- T-Lymphocytes --- Immunotherapy, Adoptive. --- therapy. --- therapeutic use. --- immunology. --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Cancer therapy --- Cancer treatment --- Therapeutic immunology --- Clinical immunology --- Therapeutics --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Lymphocytes --- Therapy --- Immunological aspects --- Treatment
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Hematopoietic stem cells --- Cellular therapy --- Hematopoietic stem cell disorders --- Cellular therapy. --- Hematopoietic Stem Cell Transplantation. --- Immunotherapy, Adoptive. --- Transplantation --- Treatment. --- Transplantation. --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- HSCs (Hematopoietic stem cells) --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells --- Cell therapy --- Cells --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Hematopoietic stem cell diseases --- Blood --- transplantation --- Therapeutic use --- Diseases
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This book is a compendium of scientific articles submitted to a Special Issue of International Journal of Molecular Sciences, fostered by MDPI and curated by Dr. Annamaria Sandomenico and Dr. Menotti Ruvo from the Institute of Biostructure and Bioimaging of the National Research Council. All articles underwent a rigorous peer review and were selected to highlight the properties that make monoclonal antibodies and their functional fragments some of the most useful and versatile assets in therapy and diagnosis.
Technology: general issues --- porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1
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This book is a compendium of scientific articles submitted to a Special Issue of International Journal of Molecular Sciences, fostered by MDPI and curated by Dr. Annamaria Sandomenico and Dr. Menotti Ruvo from the Institute of Biostructure and Bioimaging of the National Research Council. All articles underwent a rigorous peer review and were selected to highlight the properties that make monoclonal antibodies and their functional fragments some of the most useful and versatile assets in therapy and diagnosis.
porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1
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This book—entitled “Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer”—was edited as a Special Issue of Biomedicines, focusing on basic research such as genomics, epigenomics, and proteomics, as well as clinical research in the field of gynecologic oncology. The number of patients with gynecological cancer has been increasing worldwide due to its high lethality and lack of early detection tools and effective therapeutic interventions. In this regard, basic research on its pathophysiology and novel molecular targeting intervention is required to improve the prognosis of gynecologic cancer. This book contains 13 papers, including 8 original research papers and 5 reviews focusing on the basic research of gynecologic oncology. The reader can learn about state-of-the-art research and obtain extensive knowledge of the current advances in the field of gynecologic oncology. It is my hope that this book contributes towards the progress of gynecologic oncology.
Public health & preventive medicine --- nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial-mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy --- nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial-mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy
Choose an application
This book is a compendium of scientific articles submitted to a Special Issue of International Journal of Molecular Sciences, fostered by MDPI and curated by Dr. Annamaria Sandomenico and Dr. Menotti Ruvo from the Institute of Biostructure and Bioimaging of the National Research Council. All articles underwent a rigorous peer review and were selected to highlight the properties that make monoclonal antibodies and their functional fragments some of the most useful and versatile assets in therapy and diagnosis.
Technology: general issues --- porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1 --- porcine deltacoronavirus --- nucleocapsid --- monoclonal antibodies --- neurodegenerative disorders --- affibody molecules --- blood–brain barrier --- receptor-mediated transcytosis --- transferrin receptor --- AL amyloidosis --- CD38 --- anti-CD38 MoAb --- Daratumumab --- Isatuximab --- myeloma --- BCMA --- bispecific T-cell engager --- antibody-drug conjugates --- chimeric antigen receptor T-cells --- belantamab mafodotin --- idecabtagene vicleucel --- JNJ-68284528 --- Mabs --- Antibody-Drug Conjugate --- cancer therapy --- drug targeting --- payload --- cross-linking --- antibody fragment --- Fab --- scFv --- E. coli --- YKL-40 --- CHI3L1 --- monoclonal antibody --- phage display --- lung metastasis --- prostate-specific membrane antigen --- in vivo imaging --- prostate cancer --- glutamate carboxypeptidase II --- NAALADase --- immunization --- antibody --- protocol --- guinea pig --- cDNA --- chimeric antigen receptor (CAR T) --- universal CAR T --- modular CAR T --- universal immune receptor --- CAR adaptor --- adoptive immunotherapy --- split CAR --- bispecific --- polyspecificity --- pharmacokinetics --- solubility --- aggregation --- viscosity --- developability --- stability --- affinity --- specificity --- protein engineering --- self-association --- non-specific binding --- immunogenicity --- antibody fragments --- single chain --- amyloid --- oligomer --- neurotoxicity --- NUsc1
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T cells --- Tumor antigens. --- Receptors, Chimeric Antigen --- Neoplasms --- Immunotherapy, Adoptive. --- Receptors, Antigen, T-Cell. --- Cell- and Tissue-Based Therapy. --- Receptors. --- therapeutic use. --- therapy. --- Therapy, Cell --- Therapy, Tissue --- Cell Therapy --- Tissue Therapy --- Cell and Tissue Based Therapy --- Tissue Therapy, Historical --- Receptors, T-Cell Antigen --- T-Cell Antigen Receptor --- T-Cell Receptor --- Antigen Receptors, T-Cell --- T-Cell Receptors --- Antigen Receptor, T-Cell --- Antigen Receptors, T Cell --- Receptor, T-Cell --- Receptor, T-Cell Antigen --- Receptors, T Cell Antigen --- Receptors, T-Cell --- T Cell Antigen Receptor --- T Cell Receptor --- T Cell Receptors --- T-Cell Antigen Receptors --- CD3 Complex --- Genes, T-Cell Receptor --- Complementarity Determining Regions --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer --- Antigens --- Tumor markers --- T cell receptors --- T lymphocyte antigen receptors --- Cell receptors
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This book—entitled “Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer”—was edited as a Special Issue of Biomedicines, focusing on basic research such as genomics, epigenomics, and proteomics, as well as clinical research in the field of gynecologic oncology. The number of patients with gynecological cancer has been increasing worldwide due to its high lethality and lack of early detection tools and effective therapeutic interventions. In this regard, basic research on its pathophysiology and novel molecular targeting intervention is required to improve the prognosis of gynecologic cancer. This book contains 13 papers, including 8 original research papers and 5 reviews focusing on the basic research of gynecologic oncology. The reader can learn about state-of-the-art research and obtain extensive knowledge of the current advances in the field of gynecologic oncology. It is my hope that this book contributes towards the progress of gynecologic oncology.
Public health & preventive medicine --- nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial–mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy --- n/a --- epithelial-mesenchymal transition
Choose an application
This book—entitled “Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer”—was edited as a Special Issue of Biomedicines, focusing on basic research such as genomics, epigenomics, and proteomics, as well as clinical research in the field of gynecologic oncology. The number of patients with gynecological cancer has been increasing worldwide due to its high lethality and lack of early detection tools and effective therapeutic interventions. In this regard, basic research on its pathophysiology and novel molecular targeting intervention is required to improve the prognosis of gynecologic cancer. This book contains 13 papers, including 8 original research papers and 5 reviews focusing on the basic research of gynecologic oncology. The reader can learn about state-of-the-art research and obtain extensive knowledge of the current advances in the field of gynecologic oncology. It is my hope that this book contributes towards the progress of gynecologic oncology.
nucleus accumbens-associated protein 1 (NAC1) --- BEN (BANP, E5R and NAC1) domain --- sequence-specific DNA-binding protein --- solution NMR structure --- isothermal titration calorimetry (ITC) --- human cytomegalovirus --- ovarian cancer --- cancer progression --- inflammation --- immunosuppression --- endometrial carcinoma --- immune micro-environment --- immune checkpoints inhibitors --- microsatellite instability --- mismatch repair deficiency --- platelet-activating factor acetylhydrolase (PAF-AH --- PLA2G7) --- BRCA1 mutant ovarian cancer --- Wnt signaling --- pGSK3β --- β-catenin --- prognosis --- vulvar melanoma --- vaginal melanoma --- targeted therapy --- gynecological cancer --- melanoma treatment --- gene ontology --- epithelial ovarian cancers --- borderline ovarian tumors --- differentially expressed genes --- aryl hydrocarbon receptor --- epithelial–mesenchymal transition --- integrative analysis --- testin --- p16 protein --- cervical cancer --- cervical neoplasia --- immunohistochemistry --- chimeric antigen receptor --- CD44 --- adoptive immunotherapy --- NK cells --- epithelial ovarian cancer --- DNA damage response --- somatic mutation --- clear cell carcinoma --- endometrioid endometrial cancer --- DNA mismatch repair (MMR) --- MMR deficient (dMMR) --- long-term survival --- exosome --- miRNA --- biomarkers --- liquid biopsy --- interventional radiotherapy --- vaginal-cuff brachytherapy --- HDR brachytherapy --- in vivo dosimetry --- endometrial cancer --- biological planning --- drug repurposing --- non-coding RNAs --- nanocarriers --- anti-angiogenic therapy --- n/a --- epithelial-mesenchymal transition
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