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Animal biochemistry --- Adenosine --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Receptors

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Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.  Adenosine:  A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.  This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Adenosine. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Adenocard --- Adenoscan --- Composition --- Medicine. --- Neurosciences. --- Neurobiology. --- Biomedicine. --- Biology --- Chemistry --- Medical sciences --- Purine nucleosides --- Ribonucleosides

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Adenylic acid --- Adenosine --- Adenine nucleotides --- Neurotransmitters --- Physiological effect --- Testing --- Congresses --- -Adenosine --- -Adenylic acid --- -Neurotransmitters --- #Lilly --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Adenine ribonucleotide --- Adenine-ribose phosphate --- Adenosine monophosphate --- Adenosine phosphate --- Adenosine phosphoric acid --- AMP (Biochemistry) --- Adenine --- Adenine nucleoside phosphates --- Adenosine phosphates --- Purine nucleotides --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Adenylic acid - Physiological effect --- Adenosine - Physiological effect --- Adenosine - Testing --- Adenine nucleotides - Congresses --- Adenosine pharmacology --- Adenosine physiology

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Adenosine --- Research Design --- Data Adjustment --- Data Reporting --- Design, Experimental --- Designs, Experimental --- Error Sources --- Experimental Designs --- Matched Groups --- Methodology, Research --- Problem Formulation --- Research Methodology --- Research Proposal --- Research Strategy --- Research Technics --- Research Techniques --- Scoring Methods --- Experimental Design --- Adjustment, Data --- Adjustments, Data --- Data Adjustments --- Design, Research --- Designs, Research --- Error Source --- Formulation, Problem --- Formulations, Problem --- Group, Matched --- Groups, Matched --- Matched Group --- Method, Scoring --- Methods, Scoring --- Problem Formulations --- Proposal, Research --- Proposals, Research --- Reporting, Data --- Research Designs --- Research Proposals --- Research Strategies --- Research Technic --- Research Technique --- Scoring Method --- Source, Error --- Sources, Error --- Strategies, Research --- Strategy, Research --- Technic, Research --- Technics, Research --- Technique, Research --- Techniques, Research --- Research --- Clinical Trials Data Monitoring Committees --- Adenocard --- Adenoscan --- methods --- Research Design.

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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Adenosine -- Receptors. --- Pharmacokinetics. --- Purinergic P1 Receptor Antagonists. --- Receptors, Purinergic P1 -- therapeutic use. --- Adenosine --- Receptors, Purinergic --- Kinetics --- Pharmacological Phenomena --- Purinergic Antagonists --- Metabolic Phenomena --- Receptors, G-Protein-Coupled --- Physiological Phenomena --- Biochemical Phenomena --- Phenomena and Processes --- Purinergic Agents --- Receptors, Cell Surface --- Receptors, Neurotransmitter --- Neurotransmitter Agents --- Membrane Proteins --- Chemical Phenomena --- Physiological Effects of Drugs --- Molecular Mechanisms of Pharmacological Action --- Proteins --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Chemicals and Drugs --- Receptors, Purinergic P1 --- Pharmacokinetics --- Purinergic P1 Receptor Antagonists --- Health & Biological Sciences --- Human Anatomy & Physiology --- Animal Biochemistry --- Pharmacy, Therapeutics, & Pharmacology --- Receptors --- Receptors. --- Drug kinetics --- Drugs --- Kinetics, Drugs --- Adenocard --- Adenoscan --- Medicine. --- Human physiology. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Pharmacology/Toxicology. --- Human Physiology. --- Cell Biology. --- Chemical kinetics --- Pharmacology --- Purine nucleosides --- Ribonucleosides --- Metabolism --- Toxicology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Human biology --- Medical sciences --- Physiology --- Human body --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect