Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Rheumatoid arthritis is classified as auto-immune disease. Chronic inflammatory arthritis is most common in adults, occurring primarily in women from the age of 40. A better knowledge of pathophysiological mechanisms has helped in recent years to develop targeted therapies and biologic therapies. This includes monoclonal antibodies directed against TNF, a cytokine that plays a key pathogenetic role in regulating the process of inflammation, synovial proliferation and destruction of cartilage. Thus, obtaining a state of clinical remission, has now become the goal of treatment of this disease. Adalimumab, the active ingredient in Humira®, is a monoclonal humanised anti-TNF administered by subcutaneous injection at a dosis of 40 mg every two weeks. It has proven its effectiveness in terms of endpoint. However, the occurrence of side effects, mainly severe infections and reactivation of TB, requires the use with caution. Finally, advances in multidisciplinary management of RA are of great interest to improve the quality of life of patients with this chronic disease Classée parmi les maladies auto-immunes, la polyarthrite rhumatoïde est le rhumatisme inflammatoire chronique le plus fréquent de l’adulte qui survient surtout chez la femme à partir de l’âge de 40 ans. Une meilleure connaissance des mécanismes physiopathologiques a permis au cours des dernières années, le développement de traitements ciblés ou biothérapies dont les anticorps monoclonaux dirigés contre le TNFα, cytokine qui joue un rôle pathogénique clé sur la réglementation du processus d’inflammation, de prolifération synoviale et de destruction du cartilage. Ainsi, l’obtention d’un état de rémission clinique est devenue actuellement l’objectif du traitement de cette maladie. L’adalimumab, principe actif de Humira®, est un anticorps monoclonal anti-TNFα v entièrement humanisé qui s’administre par voie sous-cutanée à raison de 40 mg une fois toute les 2 semaines. Il a fait la preuve de son efficacité en terme de critères d’évaluation d’efficacité. Cependant, la survenue d’effets indésirables, principalement les infections graves et la réactivation de la tuberculose nécessite de l’utiliser avec précaution. Enfin, les progrès de la prise en charge pluridisciplinaire de la PR sont de grand intérêt afin d’améliorer la qualité de vie des patients atteints de cette maladie chronique.

Arthritis, Rheumatoid --- Anti-Inflammatory Agents --- Biological Therapy --- Lymphoma --- adalimumab --- Antirheumatic Agents --- Antibodies, Monoclonal

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This colligated Special Issue of Pharmaceutics on Precision Medicine: Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy offers to the reader a series of articles that describe the concept of Precision Medicine, discuss its implementation process and limitations, demonstrate its value by illustrating some clinical cases, and open the door to new and more sophisticated techniques and applications.

fibromyalgia (FM) --- myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) --- microRNA --- miRNome --- pharmacogenomics --- pharmacoepigenomics --- SM2miR --- Pharmaco-miR --- repoDB --- ME/CFS Common Data Elements (CDEs) --- dihydropyrimidine dehydrogenase --- DPYD --- 5-fluorouracil --- fluoropyrimidine --- therapeutic drug monitoring --- orthotopic liver transplant --- busulfan --- glutathione S-transferase --- genetic polymorphism --- limited sampling strategy --- pharmacokinetics --- clinical pharmacogenetics --- pharmacogenetic testing --- adverse drug reactions --- genotype --- phenotype --- pharmacogene --- barriers to pharmacogenetics implementation --- Sub-Saharan Africa --- chronic low back pain (cLBP) --- genetics --- personalized treatment --- polymorphism --- CYP450 --- tacrolimus --- CYP3A5 --- liver transplant --- pharmacogenomic --- minority --- data collection --- drug --- biomarker --- pharmacogenetics --- pharmacogenetic test --- personalized medicine --- gene expression --- infliximab --- adalimumab --- ulcerative colitis --- Crohn disease --- inflammatory bowel disease --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Tumor necrosis factor --- Cytokines --- Lymphotoxin-alpha --- Tumor Necrosis Factor --- Congresses --- Lymphotoxin-alpha. --- Tumor Necrosis Factor-alpha. --- -Tumor necrosis factor --- -Cachectin --- Lymphotoxin --- TNF (Immunology) --- Glycoproteins --- Growth factors --- Macrophages --- Cellular immunity --- Immune response --- Regulation --- -Congresses --- Tumor Necrosis Factor-alpha --- Cachectin-Tumor Necrosis Factor --- TNF Superfamily, Member 2 --- TNFalpha --- Cachectin --- TNF-alpha --- Tumor Necrosis Factor Ligand Superfamily Member 2 --- Cachectin Tumor Necrosis Factor --- Tumor Necrosis Factor alpha --- Certolizumab Pegol --- Adalimumab --- Infliximab --- Necrosis --- Tumor Lysis Syndrome --- Lymphotoxin-alpha3 --- Soluble Lymphotoxin-alpha --- alpha-Lymphotoxin --- TNF Superfamily, Member 1 --- TNF-beta --- Tumor Necrosis Factor Ligand Superfamily Member 1 --- Tumor Necrosis Factor-beta --- Lymphotoxin alpha --- Lymphotoxin alpha3 --- Lymphotoxin-alpha, Soluble --- Soluble Lymphotoxin alpha --- Tumor Necrosis Factor beta --- alpha Lymphotoxin --- Kankercellen. (Congres) --- Gezwellen (Kwaadaardige). (Congres) --- Cytotoxinen. (Congres) --- Antinéoplastiques. (Congrès) --- Cellules cancéreuses. (Congrès) --- Tumeurs malignes. (Congrès) --- Cytotoxines. (Congrès) --- Antineoplastische middelen. (Congres) --- Tumor necrosis factor - Congresses --- Cytokines - Congresses --- Lymphotoxin-alpha - congresses --- Tumor Necrosis Factor - congresses

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Dear Colleagues, The rapidly changing field of medicine and healthcare is increasingly adopting scientific and technological innovations, making interdisciplinary collaborations especially important. In this context, medical disciplines are becoming increasingly interlinked with other specialities and fields. A more interdisciplinary approach to the patient is needed, especially for complex patients with numerous comorbidities, most of whom are usually elderly and fragile. The greatest challenges to human health lie at the intersection of different medical fields. An interdisciplinary medical team is increasingly necessary with the rapid expansion of medical knowledge. Given the importance of interdisciplinarity in the field of medicine and research, the international journal Medicina-Lithuania has launched this Special Issue. The Special Issue has attracted the interest of different groups of researchers, and very interesting articles from different countries. Reviews or original articles dealing with interdisciplinary medical problems, as well as articles providing an up-to-date overview of the diagnostic protocols and treatments for patients with multiple comorbidities have been published. I thank all the authors for sharing their research and wish all readers a fruitful and stimulating read! Assoc. Prof. Dr. Camelia DIACONU Guest Editor

Medicine --- ectopic kidney --- locally advanced cervical cancer --- nephrectomy --- skin cancer --- squamous cell carcinoma --- basal cell carcinoma --- malignant melanoma --- surgery --- quality of life --- breast reconstruction --- timing --- mastectomy --- adjuvant therapy --- fertility preservation --- cryo-preservation --- vitrification --- breast cancer --- dietary attitude --- type 2 diabetes mellitus --- diabetes self-management --- empowerment approach --- dietary behavior --- early stage --- ovarian cancer --- para-aortic lymph node metastases --- synchronous malignancies --- cervical adenocarcinoma --- serous ovarian adenocarcinoma --- PSFT --- resection --- pulmonary adenocarcinoma --- Krukenberg tumors --- ureteral stenosis --- chronic kidney disease --- preeclampsia --- hypertension --- proteinuria --- type 2 diabetes --- hemoglobin A1c --- matrix metalloproteinases-2 and -9 --- anti-elastin antibodies --- anti-collagen IV antibodies --- diabetic retinopathy --- diabetic nephropathy --- macrovascular complications --- nephrotic syndrome --- thrombosis --- inherited risk factors --- mutation --- anticoagulation --- medical malpractice --- doctor-patient relationship --- communication --- complications --- diagnostic error --- preventive measures --- retrospective study --- children --- self-medication --- risks --- beliefs --- Mayer-Rokitansky-Küster-Hauser syndrome --- primary amenorrhea --- surgical management --- vaginal reconstruction --- plastic surgery --- oral graft versus host disease --- topical corticosteroids --- dexamethasone --- clobetasol --- budesonide --- tuberous sclerosis --- angiomyolipomatosis --- uretero-hydronephrosis --- angiofibromas --- VCAM-1 --- E-selectin --- psoriasis --- methotrexate --- adalimumab --- colosalpingeal fistula --- enterotubal fistula --- diverticular fistulation --- diagnosis --- hysteroscopy management --- pregnancy-associated breast cancer --- Romania --- primary --- pleural --- hydatidosis --- Albendazole --- echinoccocus --- caudal duplication syndrome --- colorectal duplication --- genitourinary duplication --- congenital malformation --- pediatric surgery --- SARS-CoV-2 --- COVID-19 --- SIADH --- dyselectrolytemia --- hyponatremia --- Silesian Voivodeship --- gold hour --- cardiovascular diseases --- Medical Emergency Team --- acute cholecystitis --- laparoscopic cholecystectomy --- elderly --- safety --- young lung cancer --- depression --- anxiety --- multiple correspondence analysis --- k-means clustering --- ectopic kidney --- locally advanced cervical cancer --- nephrectomy --- skin cancer --- squamous cell carcinoma --- basal cell carcinoma --- malignant melanoma --- surgery --- quality of life --- breast reconstruction --- timing --- mastectomy --- adjuvant therapy --- fertility preservation --- cryo-preservation --- vitrification --- breast cancer --- dietary attitude --- type 2 diabetes mellitus --- diabetes self-management --- empowerment approach --- dietary behavior --- early stage --- ovarian cancer --- para-aortic lymph node metastases --- synchronous malignancies --- cervical adenocarcinoma --- serous ovarian adenocarcinoma --- PSFT --- resection --- pulmonary adenocarcinoma --- Krukenberg tumors --- ureteral stenosis --- chronic kidney disease --- preeclampsia --- hypertension --- proteinuria --- type 2 diabetes --- hemoglobin A1c --- matrix metalloproteinases-2 and -9 --- anti-elastin antibodies --- anti-collagen IV antibodies --- diabetic retinopathy --- diabetic nephropathy --- macrovascular complications --- nephrotic syndrome --- thrombosis --- inherited risk factors --- mutation --- anticoagulation --- medical malpractice --- doctor-patient relationship --- communication --- complications --- diagnostic error --- preventive measures --- retrospective study --- children --- self-medication --- risks --- beliefs --- Mayer-Rokitansky-Küster-Hauser syndrome --- primary amenorrhea --- surgical management --- vaginal reconstruction --- plastic surgery --- oral graft versus host disease --- topical corticosteroids --- dexamethasone --- clobetasol --- budesonide --- tuberous sclerosis --- angiomyolipomatosis --- uretero-hydronephrosis --- angiofibromas --- VCAM-1 --- E-selectin --- psoriasis --- methotrexate --- adalimumab --- colosalpingeal fistula --- enterotubal fistula --- diverticular fistulation --- diagnosis --- hysteroscopy management --- pregnancy-associated breast cancer --- Romania --- primary --- pleural --- hydatidosis --- Albendazole --- echinoccocus --- caudal duplication syndrome --- colorectal duplication --- genitourinary duplication --- congenital malformation --- pediatric surgery --- SARS-CoV-2 --- COVID-19 --- SIADH --- dyselectrolytemia --- hyponatremia --- Silesian Voivodeship --- gold hour --- cardiovascular diseases --- Medical Emergency Team --- acute cholecystitis --- laparoscopic cholecystectomy --- elderly --- safety --- young lung cancer --- depression --- anxiety --- multiple correspondence analysis --- k-means clustering

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Dear Colleagues, The rapidly changing field of medicine and healthcare is increasingly adopting scientific and technological innovations, making interdisciplinary collaborations especially important. In this context, medical disciplines are becoming increasingly interlinked with other specialities and fields. A more interdisciplinary approach to the patient is needed, especially for complex patients with numerous comorbidities, most of whom are usually elderly and fragile. The greatest challenges to human health lie at the intersection of different medical fields. An interdisciplinary medical team is increasingly necessary with the rapid expansion of medical knowledge. Given the importance of interdisciplinarity in the field of medicine and research, the international journal Medicina-Lithuania has launched this Special Issue. The Special Issue has attracted the interest of different groups of researchers, and very interesting articles from different countries. Reviews or original articles dealing with interdisciplinary medical problems, as well as articles providing an up-to-date overview of the diagnostic protocols and treatments for patients with multiple comorbidities have been published. I thank all the authors for sharing their research and wish all readers a fruitful and stimulating read! Assoc. Prof. Dr. Camelia DIACONU Guest Editor

ectopic kidney --- locally advanced cervical cancer --- nephrectomy --- skin cancer --- squamous cell carcinoma --- basal cell carcinoma --- malignant melanoma --- surgery --- quality of life --- breast reconstruction --- timing --- mastectomy --- adjuvant therapy --- fertility preservation --- cryo-preservation --- vitrification --- breast cancer --- dietary attitude --- type 2 diabetes mellitus --- diabetes self-management --- empowerment approach --- dietary behavior --- early stage --- ovarian cancer --- para-aortic lymph node metastases --- synchronous malignancies --- cervical adenocarcinoma --- serous ovarian adenocarcinoma --- PSFT --- resection --- pulmonary adenocarcinoma --- Krukenberg tumors --- ureteral stenosis --- chronic kidney disease --- preeclampsia --- hypertension --- proteinuria --- type 2 diabetes --- hemoglobin A1c --- matrix metalloproteinases-2 and -9 --- anti-elastin antibodies --- anti-collagen IV antibodies --- diabetic retinopathy --- diabetic nephropathy --- macrovascular complications --- nephrotic syndrome --- thrombosis --- inherited risk factors --- mutation --- anticoagulation --- medical malpractice --- doctor–patient relationship --- communication --- complications --- diagnostic error --- preventive measures --- retrospective study --- children --- self-medication --- risks --- beliefs --- Mayer–Rokitansky–Küster–Hauser syndrome --- primary amenorrhea --- surgical management --- vaginal reconstruction --- plastic surgery --- oral graft versus host disease --- topical corticosteroids --- dexamethasone --- clobetasol --- budesonide --- tuberous sclerosis --- angiomyolipomatosis --- uretero-hydronephrosis --- angiofibromas --- VCAM-1 --- E-selectin --- psoriasis --- methotrexate --- adalimumab --- colosalpingeal fistula --- enterotubal fistula --- diverticular fistulation --- diagnosis --- hysteroscopy management --- pregnancy-associated breast cancer --- Romania --- primary --- pleural --- hydatidosis --- Albendazole --- echinoccocus --- caudal duplication syndrome --- colorectal duplication --- genitourinary duplication --- congenital malformation --- pediatric surgery --- SARS-CoV-2 --- COVID-19 --- SIADH --- dyselectrolytemia --- hyponatremia --- Silesian Voivodeship --- gold hour --- cardiovascular diseases --- Medical Emergency Team --- acute cholecystitis --- laparoscopic cholecystectomy --- elderly --- safety --- young lung cancer --- depression --- anxiety --- multiple correspondence analysis --- k-means clustering --- n/a --- doctor-patient relationship --- Mayer-Rokitansky-Küster-Hauser syndrome