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The magnitude and rapidity of the changes in the concentrations of APPs, together with their short half-life, suggest an important role for these proteins in the establishment of host defense. APPs are regarded as having general functions in trapping of micro-organisms and their products, in activating complement, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free radicals, and in modulating the hosts immune response. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their function during health and disease remains incompletely defined.

Acute phase proteins. --- Acute phase reactants --- Inflammation --- Proteins --- Mediators --- Immunology

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Methylprednisolone --- Shock, Septic --- Cardiopulmonary Bypass --- Coronary Artery Bypass --- Acute-Phase Proteins --- Endotoxins --- therapeutic use --- blood --- metabolism --- toxicity

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Immunology. Immunopathology --- Acute phase reaction --- Alpha macroglobulins --- Immune response --- Interleukin-6 --- Acute Phase Proteins --- Gene Expression Regulation --- Genes, Immune Response --- Inflammation --- Interleukins --- ACUTE PHASE PROTEINS --- GENE EXPRESSION REGULATION --- GENES --- INFLAMMATION --- INTERLEUKINS --- Congresses. --- Physiological effect --- Regulation --- congresses. --- IMMUNE RESPONSE --- Acute phase proteins --- Gene expression regulation --- Genes --- Genes, immune response --- Congresses --- Genetic regulation.

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Pathological biochemistry --- Pathological haematology --- Orthopaedics. Traumatology. Plastic surgery --- C-reactive protein --- Inflammation --- Blood proteins --- Congresses --- -C-reactive protein --- -Inflammation --- -#Lilly --- Inflammatory process --- Pathology --- Anti-inflammatory agents --- Acute phase proteins --- Globulins --- Serum albumin --- Plasma proteins --- Serum proteins --- Blood plasma --- Proteins --- Serum --- Congresses. --- Physiology --- #Lilly --- C-reactive protein - Congresses --- Inflammation - Congresses --- Blood proteins - Congresses

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This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution.  Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail.  The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP. .

Forensic medicine. --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- C-reactive protein. --- Acute phase proteins --- Globulins --- Serum albumin --- Human physiology. --- Medicine. --- Biotechnology. --- Human Physiology. --- Molecular Medicine. --- Plasma Physics. --- Forensic Science. --- Forensic medicine --- Injuries (Law) --- Jurisprudence, Medical --- Legal medicine --- Forensic sciences --- Medicine --- Medical laws and legislation --- Chemical engineering --- Genetic engineering --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Human body --- Health Workforce --- Molecular biology. --- Plasma (Ionized gases). --- Forensic science. --- Criminalistics --- Forensic science --- Science --- Criminal investigation --- Gaseous discharge --- Gaseous plasma --- Magnetoplasma --- Ionized gases --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology