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Leukemia. --- Leukemia, Lymphoid. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Leukemia, Lymphocytic --- Lymphocytic Leukemia --- Lymphoid Leukemia --- Leukemias, Lymphocytic --- Leukemias, Lymphoid --- Lymphocytic Leukemias --- Lymphoid Leukemias --- Lymphatic Diseases --- Lymphoblastic leukemia. --- Precursor Cell Lymphoblastic Leukemia-Lymphoma --- ALL, Childhood --- Acute Lymphoid Leukemia --- Leukemia, Acute Lymphoblastic --- Leukemia, Lymphoblastic, Acute --- Leukemia, Lymphoblastic, Acute, L1 --- Leukemia, Lymphoblastic, Acute, L2 --- Leukemia, Lymphoblastic, Acute, Philadelphia-Positive --- Leukemia, Lymphocytic, Acute --- Leukemia, Lymphocytic, Acute, L1 --- Leukemia, Lymphocytic, Acute, L2 --- Lymphoblastic Leukemia, Acute --- Lymphoblastic Leukemia, Acute, Adult --- Lymphoblastic Leukemia, Acute, Childhood --- Lymphoblastic Leukemia, Acute, L1 --- Lymphoblastic Leukemia, Acute, L2 --- Lymphocytic Leukemia, L1 --- Lymphocytic Leukemia, L2 --- Leukemia, Lymphoblastic --- Leukemia, Lymphoid, Acute --- Lymphoblastic Leukemia --- Lymphoblastic Lymphoma --- Lymphocytic Leukemia, Acute --- Lymphoma, Lymphoblastic --- Acute Lymphoblastic Leukemia --- Acute Lymphocytic Leukemia --- Childhood ALL --- L1 Lymphocytic Leukemia --- L2 Lymphocytic Leukemia --- Leukemia, Acute Lymphocytic --- Leukemia, Acute Lymphoid --- Leukemia, L1 Lymphocytic --- Leukemia, L2 Lymphocytic --- Lymphoid Leukemia, Acute --- Precursor Cell Lymphoblastic Leukemia Lymphoma --- Acute lymphocytic leukemia --- Lymphocytic leukemia

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New Agents for the Treatment of Acute Lymphoblastic Leukemia (ALL), examines the strategies for the use of new agents as well as possible targets of therapy in this disease. Though associated with high cure rates, relapsed disease has a poor outcome. Moreover, therapy is unduly prolonged and toxic. For over 4 decades, no new drugs have been available and now we have a surfeit. The challenge is to design trials to evaluate the potential efficacy of non-targeted therapy in a disease with good outcome. An increasing number of pathways, amenable to targeted therapy are also being identified. The heterogeneity of ALL suggests that targeted therapy at the moment will need to be tailored to the patient. How then can such drugs be evaluated within conventional clinical trials? These are the crossroads we have reached in acute lymphoblastic leukemia and this book discusses and proposes some solutions to these issues.

Medicine. --- Oncology. --- Toxicology. --- Leukemia --- Outcome Assessment (Health Care) --- Epidemiologic Study Characteristics as Topic --- Prognosis --- Therapeutics --- Leukemia, Lymphoid --- Age Groups --- Therapeutic Uses --- Evaluation Studies as Topic --- Diagnosis --- Outcome and Process Assessment (Health Care) --- Investigative Techniques --- Health Care Evaluation Mechanisms --- Persons --- Lymphoproliferative Disorders --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Epidemiologic Methods --- Pharmacologic Actions --- Named Groups --- Public Health --- Immunoproliferative Disorders --- Quality of Health Care --- Chemical Actions and Uses --- Neoplasms by Histologic Type --- Lymphatic Diseases --- Immune System Diseases --- Environment and Public Health --- Health Services Administration --- Hemic and Lymphatic Diseases --- Neoplasms --- Chemicals and Drugs --- Health Care Quality, Access, and Evaluation --- Diseases --- Health Care --- Clinical Trials as Topic --- Treatment Outcome --- Adolescent --- Child --- Precursor Cell Lymphoblastic Leukemia-Lymphoma --- Antineoplastic Agents --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Hematologic Diseases --- Oncology --- Lymphoblastic leukemia --- Treatment. --- Acute lymphocytic leukemia --- Leukemia, Lymphoblastic --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Lymphocytic leukemia --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect