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Actinomycetales --- Actinomycetales Infections --- Fungi --- Mycoses --- Medical mycology --- Mycologie médicale --- MYCOSES --- FUNGI --- Actinomycetales Infections. --- Actinomycetales. --- Fungi. --- Mycoses. --- Medical microbiology --- Mycology --- Pathogenic fungi --- Fungus Diseases --- Disease, Fungus --- Diseases, Fungus --- Fungus Disease --- Fungi, Filamentous --- Molds --- Filamentous Fungi --- Filamentous Fungus --- Fungus --- Fungus, Filamentous --- Mold --- Allergens --- Fungal Proteins --- Microbiology --- Corynebacteriaceae --- Coryneform Group --- Infections, Actinomycetales --- Infections, Actinomycete --- Actinomycete Infections --- Actinomycetales Infection --- Actinomycete Infection --- Infection, Actinomycetales --- Infection, Actinomycete --- Medical mycology. --- Fungal Diseases --- Fungal Infections --- Fungus Infections --- Disease, Fungal --- Diseases, Fungal --- Fungal Disease --- Fungal Infection --- Fungus Infection --- Infection, Fungal --- Infection, Fungus --- Infections, Fungal --- Infections, Fungus --- Mycologie médicale

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''With their evolutionary story of one of nature's most enduring and adaptable human pathogens, Mycobacterium tuberculosis, two eminent paleoepidemiologists lay to rest the misconception that our medical technology has and will continue to conquer infectious disease.

Epidemiology. --- History. --- Paleopathology. --- Tuberculosis. --- Tuberculosis --- Paleopathology --- Mycobacterium Infections --- Paleontology --- Actinomycetales Infections --- Anthropology, Physical --- Gram-Positive Bacterial Infections --- Anthropology --- Bacterial Infections --- Social Sciences --- Bacterial Infections and Mycoses --- Anthropology, Education, Sociology and Social Phenomena --- Diseases --- Public Health --- Health & Biological Sciences --- Communicable Diseases --- Koch's Disease --- Kochs Disease --- Mycobacterium tuberculosis Infection --- Infection, Mycobacterium tuberculosis --- Infections, Mycobacterium tuberculosis --- Koch Disease --- Mycobacterium tuberculosis Infections --- Tuberculoses --- Antitubercular Agents --- Tuberculin Test --- Interferon-gamma Release Tests --- Science, Social --- Sciences, Social --- Social Science --- Bacterial Infection --- Infection, Bacterial --- Infections, Bacterial --- Bacterial Disease --- Bacterial Diseases --- Infections, Gram-Positive Bacterial --- Bacterial Infections, Gram-Positive --- Bacterial Infection, Gram-Positive --- Bacterial Infections, Gram Positive --- Gram Positive Bacterial Infections --- Gram-Positive Bacterial Infection --- Infection, Gram-Positive Bacterial --- Infections, Gram Positive Bacterial --- Physical Anthropology --- Infections, Actinomycetales --- Infections, Actinomycete --- Actinomycete Infections --- Actinomycetales Infection --- Actinomycete Infection --- Infection, Actinomycetales --- Infection, Actinomycete --- Phylogeography --- Infections, Mycobacterium --- Infection, Mycobacterium --- Mycobacterium Infection --- Medical archaeology --- Pathology --- Consumption (Disease) --- Lungs --- Phthisis --- Pulmonary tuberculosis --- TB (Disease) --- Chest --- Mycobacterial diseases --- Mycobacterium tuberculosis --- History --- Epidemiology --- Taphonomy

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Tuberculosis --- BCG Vaccine --- Tuberculosis Vaccines --- Mycobacterium Infections --- Actinomycetales Infections --- Bacterial Vaccines --- Gram-Positive Bacterial Infections --- Vaccines --- Biological Products --- Bacterial Infections --- Complex Mixtures --- Bacterial Infections and Mycoses --- Diseases --- Chemicals and Drugs --- Infectious Diseases --- Medicine --- Health & Biological Sciences --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Complex Extract --- Complex Mixture --- Crude Extract --- Mixtures, Complex --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- Bacterial Infection --- Infection, Bacterial --- Infections, Bacterial --- Bacterial Disease --- Bacterial Diseases --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biologics --- Biopharmaceutical --- Natural Product --- Natural Products --- Drug, Biologic --- Drug, Biological --- Drugs, Biologic --- Drugs, Biological --- Medicine, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Product, Biologic --- Product, Biological --- Product, Natural --- Biological Factors --- Vaccine --- Infections, Gram-Positive Bacterial --- Bacterial Infections, Gram-Positive --- Bacterial Infection, Gram-Positive --- Bacterial Infections, Gram Positive --- Gram Positive Bacterial Infections --- Gram-Positive Bacterial Infection --- Infection, Gram-Positive Bacterial --- Infections, Gram Positive Bacterial --- Bacterial Vaccine --- Bacterin --- Vaccine, Bacterial --- Vaccines, Bacterial --- Infections, Actinomycetales --- Infections, Actinomycete --- Actinomycete Infections --- Actinomycetales Infection --- Actinomycete Infection --- Infection, Actinomycetales --- Infection, Actinomycete --- Infections, Mycobacterium --- Infection, Mycobacterium --- Mycobacterium Infection --- Vaccines, Tuberculosis --- Calmette's Vaccine --- Bacillus Calmette Guerin Vaccine --- Calmette Guerin Bacillus Vaccine --- Calmette Vaccine --- Calmettes Vaccine --- Vaccine, BCG --- Vaccine, Calmette's --- Koch's Disease --- Kochs Disease --- Mycobacterium tuberculosis Infection --- Infection, Mycobacterium tuberculosis --- Infections, Mycobacterium tuberculosis --- Koch Disease --- Mycobacterium tuberculosis Infections --- Tuberculoses --- Antitubercular Agents --- Tuberculin Test --- Interferon-gamma Release Tests --- history. --- prevention & control. --- North America. --- Northern America --- Drug Therapy --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Pharmacologic Actions --- drug therapy --- therapeutic use

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Medical policy --- Public health --- HIV infections --- Malaria --- Tuberculosis --- Quality of Health Care --- HIV Infections --- Health Policy --- Health Services Administration --- Sexually Transmitted Diseases, Viral --- Health Care --- Health Occupations --- Health Care Quality, Access, and Evaluation --- Public Policy --- Lentivirus Infections --- Protozoan Infections --- Mycobacterium Infections --- Immunologic Deficiency Syndromes --- Disciplines and Occupations --- Social Control Policies --- Parasitic Diseases --- Sexually Transmitted Diseases --- Immune System Diseases --- Actinomycetales Infections --- Retroviridae Infections --- Virus Diseases --- Policy --- Diseases --- Gram-Positive Bacterial Infections --- RNA Virus Infections --- Social Control, Formal --- Sociology --- Bacterial Infections --- Social Sciences --- Health Care Economics and Organizations --- Bacterial Infections and Mycoses --- Anthropology, Education, Sociology and Social Phenomena --- Administration, Health Services --- Health Services --- Healthcare Policy --- National Health Policy --- Health Policies --- Health Policy, National --- Healthcare Policies --- National Health Policies --- Policy, Health --- Policy, Healthcare --- Policy, National Health --- Policy Making --- HIV Coinfection --- HTLV-III Infections --- HTLV-III-LAV Infections --- T-Lymphotropic Virus Type III Infections, Human --- Coinfection, HIV --- Coinfections, HIV --- HIV Coinfections --- HIV Infection --- HTLV III Infections --- HTLV III LAV Infections --- HTLV-III Infection --- HTLV-III-LAV Infection --- Infection, HIV --- Infection, HTLV-III --- Infection, HTLV-III-LAV --- Infections, HIV --- Infections, HTLV-III --- Infections, HTLV-III-LAV --- T Lymphotropic Virus Type III Infections, Human --- Koch's Disease --- Kochs Disease --- Mycobacterium tuberculosis Infection --- Infection, Mycobacterium tuberculosis --- Infections, Mycobacterium tuberculosis --- Koch Disease --- Mycobacterium tuberculosis Infections --- Tuberculoses --- Antitubercular Agents --- Tuberculin Test --- Interferon-gamma Release Tests --- Pharmacy Audit --- Quality of Care --- Quality of Healthcare --- Audit, Pharmacy --- Care Quality --- Health Care Quality --- Healthcare Quality --- Pharmacy Audits --- Healthcare Economics and Organizations --- Health Care Economics --- Health Economics --- Healthcare Economics --- Care Economic, Health --- Economic, Health --- Economic, Health Care --- Economic, Healthcare --- Economics, Health Care --- Health Care Economic --- Health Economic --- Healthcare Economic --- Science, Social --- Sciences, Social --- Social Science --- Bacterial Infection --- Infection, Bacterial --- Infections, Bacterial --- Bacterial Disease --- Bacterial Diseases --- General Social Development and Population --- Regulation --- Social Control --- Control, Social --- Controls, Social --- Formal Social Control --- Formal Social Controls --- Regulations --- Social Controls --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Infections, Gram-Positive Bacterial --- Bacterial Infections, Gram-Positive --- Bacterial Infection, Gram-Positive --- Bacterial Infections, Gram Positive --- Gram Positive Bacterial Infections --- Gram-Positive Bacterial Infection --- Infection, Gram-Positive Bacterial --- Infections, Gram Positive Bacterial --- Infections, Retroviridae --- Infections, Retrovirus --- XMRV Infection --- Xenotropic MuLV-related Virus Infection --- Xenotropic Murine Leukemia Virus-related Virus Infection --- Retrovirus Infections --- Infection, Retroviridae --- Infection, Retrovirus --- Infection, XMRV --- Infections, XMRV --- Retroviridae Infection --- Retrovirus Infection --- XMRV Infections --- Xenotropic MuLV related Virus Infection --- Xenotropic Murine Leukemia Virus related Virus Infection --- Infections, Actinomycetales --- Infections, Actinomycete --- Actinomycete Infections --- Actinomycetales Infection --- Actinomycete Infection --- Infection, Actinomycetales --- Infection, Actinomycete --- Diseases of Immune System --- Immune Diseases --- Immunological Diseases --- Immune Disorders --- Immune System Disorders --- Immunologic Diseases --- Disease, Immune --- Disease, Immune System --- Disease, Immunologic --- Disease, Immunological --- Disorder, Immune System --- Immune Disease --- Immune Disorder --- Immune System Disease --- Immune System Disorder --- Immunologic Disease --- Immunological Disease --- STDs --- STIs --- Sexually Transmitted Infections --- Venereal Diseases --- Disease, Sexually Transmitted --- Disease, Venereal --- Diseases, Sexually Transmitted --- Diseases, Venereal --- Infection, Sexually Transmitted --- Infections, Sexually Transmitted --- STI --- Sexually Transmitted Disease --- Sexually Transmitted Infection --- Transmitted Infection, Sexually --- Transmitted Infections, Sexually --- Venereal Disease --- Venereology --- Reproductive Tract Infections --- Policies --- Parasite Infections --- Parasitic Infections --- Disease, Parasitic --- Diseases, Parasitic --- Infection, Parasite --- Infection, Parasitic --- Infections, Parasite --- Infections, Parasitic --- Parasite Infection --- Parasitic Disease --- Parasitic Infection --- Control Policies, Social --- Control Policy, Social --- Policies, Social Control --- Policy, Social Control --- Social Control Policy --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Deficiency Syndrome, Immunologic --- Deficiency Syndromes, Antibody --- Deficiency Syndromes, Immunologic --- Immunologic Deficiency Syndrome --- Immunological Deficiency Syndromes --- Antibody Deficiency Syndrome --- Antibody Deficiency Syndromes --- Deficiency Syndrome, Antibody --- Deficiency Syndrome, Immunological --- Deficiency Syndromes, Immunological --- Immunological Deficiency Syndrome --- Syndrome, Antibody Deficiency --- Syndrome, Immunologic Deficiency --- Syndrome, Immunological Deficiency --- Syndromes, Antibody Deficiency --- Syndromes, Immunologic Deficiency --- Syndromes, Immunological Deficiency --- Antibodies --- Infections, Protozoan --- Histomoniasis --- Histomoniases --- Infection, Protozoan --- Protozoan Infection --- Infections, Mycobacterium --- Infection, Mycobacterium --- Mycobacterium Infection --- Infections, Lentivirus --- Infection, Lentivirus --- Lentivirus Infection --- Affirmative Action --- Migration Policy --- Population Policy --- Social Protection --- Social Policy --- Action, Affirmative --- Migration Policies --- Policies, Migration --- Policies, Population --- Policies, Public --- Policies, Social --- Policy, Migration --- Policy, Population --- Policy, Public --- Policy, Social --- Population Policies --- Protection, Social --- Public Policies --- Social Policies --- Healthcare Quality, Access, and Evaluation --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Sexually Transmitted Disease, Viral --- Viral Sexually Transmitted Disease --- Viral Sexually Transmitted Diseases --- Viral Venereal Diseases --- Venereal Diseases, Viral --- Disease, Viral Venereal --- Diseases, Viral Venereal --- Venereal Disease, Viral --- Viral Venereal Disease --- Infections, Plasmodium --- Paludism --- Marsh Fever --- Plasmodium Infections --- Remittent Fever --- Fever, Marsh --- Fever, Remittent --- Infection, Plasmodium --- Plasmodium Infection --- Consumption (Disease) --- Lungs --- Phthisis --- Pulmonary tuberculosis --- TB (Disease) --- Chest --- Mycobacterial diseases --- Mycobacterium tuberculosis --- Ague --- Chills and fever --- Intermittent fever --- Malarial fever --- Fever --- Protozoan diseases --- Health care policy --- Health policy --- Medical care --- Medicine and state --- Policy, Medical --- Public health policy --- State and medicine --- Science and state --- Social policy --- organization & administration --- deficiency --- Government policy --- Health Care Policies --- Care Policies, Health --- Health Care Policy --- Policies, Health --- Policies, Health Care --- Policies, Healthcare --- Policy, Health Care

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The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.

Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa