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Salicylates --- Aspirin --- Aspirin. --- 2-(Acetyloxy)benzoic Acid --- Acetysal --- Acylpyrin --- Aloxiprimum --- Colfarit --- Dispril --- Easprin --- Ecotrin --- Endosprin --- Magnecyl --- Micristin --- Polopirin --- Polopiryna --- Solprin --- Solupsan --- Zorprin --- Acetylsalicylic Acid --- Acid, Acetylsalicylic --- pharmacology. --- Acetylsalicylic acid --- Analgesics --- Nonsteroidal anti-inflammatory agents --- Salicylic acid --- pharmacology --- Salicylates. --- Benzoates

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Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient's organism. Investigations into the mechanisms of aspirin-induced asthma

Asthma --- Melatonin. --- Blood platelets. --- Aspirin --- Pathophysiology. --- Etiology. --- Side effects. --- Acetylsalicylic acid --- Analgesics --- Nonsteroidal anti-inflammatory agents --- Salicylic acid --- Platelets --- Thrombocytes --- Blood cells --- Megakaryocytes --- Acetylmethoxytryptamine --- Methoxyindolylethylacetamide --- Hormones --- Pineal gland --- Tryptamine --- Bronchial asthma --- Bronchi --- Lungs --- Respiratory allergy --- Secretions --- Diseases --- Diseases, Obstructive

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This brief traces the story of one of our most common medicines – aspirin. On a journey involving science, diverse characters, shady business deals, innovative advertising and good old-fashioned luck, Rooney and Campbell describe how aspirin was developed and marketed on a global scale. Starting at the beginning of the twentieth century, the authors explain the use of aspirin during the First World War, the development of competition drugs such as ibuprofen during the interwar years, and the application of aspirin to heart disease in the 1950s and 1960s. On a broader level, Rooney and Campbell show that the development of America’s modern pharmaceuticals was a complex weaving of chemistry and mass culture. They argue that aspirin’s story provides a way to understand the application of complex chemical formulas in medical results. This brief is of interest to historians of chemistry and medicine as well as the general educated reader.

Chemistry. --- Medicinal chemistry. --- Chemistry --- Medicine --- History of Chemistry. --- Medicinal Chemistry. --- History of Medicine. --- History. --- Aspirin --- Salicylic acid. --- Therapeutics --- Acetylsalicylic acid --- Hydroxy acids --- Analgesics --- Nonsteroidal anti-inflammatory agents --- Salicylic acid --- Chemistry-History. --- Biochemistry. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Composition --- Health Workforce --- Chemistry—History. --- Medicine—History. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a

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The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as well as control dose and release behavior. Furthermore, the low cost and ease of use of 3DP systems means that the possibility of manufacturing medicines and medical devices at the point of dispensing or at the point of use could become a reality. 3DP thus offers the perfect innovative manufacturing route to address the critical capability gap that hinders the widespread exploitation of personalized medicines for molecules that are currently not easy to deliver. This Special Issue will address new developments in the area of 3D printing and bioprinting for drug delivery applications, covering the recent advantages and future directions of additive manufacturing for pharmaceutical products.

Medicine --- digital pharmacy --- fused deposition modeling 3D printing --- modified drug release --- personalized medicines --- telemedicine --- three dimensional printing --- additive manufacturing --- 3D printed drug products --- printlets --- personalised medicines --- personalized pharmaceuticals --- multiple units --- spheroids --- beads --- acetaminophen --- 3D printing --- fused filament fabrication --- lignin --- antioxidant materials --- wound dressing --- modified release --- filament extrusion --- fused layer modeling --- theophylline --- high API load --- three-dimensional printing --- fixed-dose combinations --- tablets --- multiple-layer dosage forms --- stereolithography --- vat polymerisation --- fused deposition modeling --- polylactic acid --- chemical modification --- MTT assay --- biofilm formation --- warfarin --- semisolid extrusion 3D printing --- inkjet printing --- orodispersible film --- oral powder --- pediatric --- hospital pharmacy --- personalized medicine --- on-demand manufacturing --- drug delivery --- micromedicine --- drug development --- micro-swimmer --- micro-implant --- oral dosages --- microneedle --- high-precision targeting --- controlled release --- geometry --- resolution --- feature size --- release profile --- vascularization --- digital light processing technology --- neural networks --- optimization --- prediction --- FMD --- pregabalin --- gastric floating --- complex structures --- patient-specific --- structural design --- gums --- Fused Deposition Modeling 3D Printing --- processing parameters --- pharmaceutical quality control --- hot-melt extrusion --- solid dosage forms --- 3D printed oral dosage forms --- sustained drug release tablets --- photopolymerization --- paracetamol (acetaminophen) --- aspirin (acetylsalicylic acid) --- amorphous solid dispersion --- poor solubility --- fixed dose combination --- stencil printing --- pharmacoprinting --- orodispersible discs --- orodisperible films --- floating systems --- pulsatile release --- chronotherapeutic delivery --- wound-healing --- 3D bio-printing --- pectin --- propolis --- cyclodextrin --- 3D bio-inks --- fused deposition modelling --- extrusion --- vaginal meshes --- mechanical properties --- drug release --- anti-infective devices --- pelvic organ prolapse --- stress urinary incontinence --- gastro-retentive floating system --- dissolution kinetics --- implantable devices --- subcutaneous --- biodegradable --- prolonged drug delivery --- polymers --- pharmaceuticals --- extrusion-based 3D printing --- fused deposition modeling (FDM) --- pressure-assisted microsyringe (PAM) --- materials --- process --- 3D bioprinting --- polymeric ink --- pseudo-bone --- implantable scaffold --- computer-aided design (CAD) design --- bioprinting --- computer-aided design (CAD) --- pharmaceutics --- digital pharmacy --- fused deposition modeling 3D printing --- modified drug release --- personalized medicines --- telemedicine --- three dimensional printing --- additive manufacturing --- 3D printed drug products --- printlets --- personalised medicines --- personalized pharmaceuticals --- multiple units --- spheroids --- beads --- acetaminophen --- 3D printing --- fused filament fabrication --- lignin --- antioxidant materials --- wound dressing --- modified release --- filament extrusion --- fused layer modeling --- theophylline --- high API load --- three-dimensional printing --- fixed-dose combinations --- tablets --- multiple-layer dosage forms --- stereolithography --- vat polymerisation --- fused deposition modeling --- polylactic acid --- chemical modification --- MTT assay --- biofilm formation --- warfarin --- semisolid extrusion 3D printing --- inkjet printing --- orodispersible film --- oral powder --- pediatric --- hospital pharmacy --- personalized medicine --- on-demand manufacturing --- drug delivery --- micromedicine --- drug development --- micro-swimmer --- micro-implant --- oral dosages --- microneedle --- high-precision targeting --- controlled release --- geometry --- resolution --- feature size --- release profile --- vascularization --- digital light processing technology --- neural networks --- optimization --- prediction --- FMD --- pregabalin --- gastric floating --- complex structures --- patient-specific --- structural design --- gums --- Fused Deposition Modeling 3D Printing --- processing parameters --- pharmaceutical quality control --- hot-melt extrusion --- solid dosage forms --- 3D printed oral dosage forms --- sustained drug release tablets --- photopolymerization --- paracetamol (acetaminophen) --- aspirin (acetylsalicylic acid) --- amorphous solid dispersion --- poor solubility --- fixed dose combination --- stencil printing --- pharmacoprinting --- orodispersible discs --- orodisperible films --- floating systems --- pulsatile release --- chronotherapeutic delivery --- wound-healing --- 3D bio-printing --- pectin --- propolis --- cyclodextrin --- 3D bio-inks --- fused deposition modelling --- extrusion --- vaginal meshes --- mechanical properties --- drug release --- anti-infective devices --- pelvic organ prolapse --- stress urinary incontinence --- gastro-retentive floating system --- dissolution kinetics --- implantable devices --- subcutaneous --- biodegradable --- prolonged drug delivery --- polymers --- pharmaceuticals --- extrusion-based 3D printing --- fused deposition modeling (FDM) --- pressure-assisted microsyringe (PAM) --- materials --- process --- 3D bioprinting --- polymeric ink --- pseudo-bone --- implantable scaffold --- computer-aided design (CAD) design --- bioprinting --- computer-aided design (CAD) --- pharmaceutics