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Acanthamoeba keratitis --- Acanthamoeba --- Amebiasis

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This book provides the concise descriptions of the basic and clinical knowledge about Acanthamoba keratitis, including characteristics of pathogen, risk factors, clinical manifestations, diagnosis and treatment with abundant figure illustrations and typical cases to ophthalmological practitioners and researchers. Acanthamoeba pathogen is widely distributed in the nature. However, Acanthamoeba keratitis is generally considered as a type of sight-threatening keratitis that is difficult to treat. At early stage Acanthamoeba keratitis usually shows atypical clinical manifestations, that are often misdiagnosed as viral or bacterial keratitis. Moreover, there are not approved topical anti-amoebicdrugs available up to now. We hope ophthalmological practitioners can obtain a comprehensive understanding of this infection through this book.   Xuguang Sun is a professor of Ophthalmology at Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Keratitis. --- Acanthamoeba. --- Medicine. --- Ophthalmology. --- Medicine & Public Health. --- Acanthamoebidae --- Cornea --- Eye --- Inflammation --- Diseases --- Medicine

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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Research & information: general --- Biology, life sciences --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a

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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Research & information: general --- Biology, life sciences --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products

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Legionella spp. are ubiquitous microorganisms that are widely distributed in aquatic environments. Water systems of large buildings, such as hospitals, hotels, and rental units are often contaminated by legionellae and various parameters such as physical, chemical, and microbial building water system characteristics can influence Legionella occurrence. A range of physical and chemical disinfection methods have been proposed to control Legionella contamination; however, to date, the most effective procedures have not been defined. There is a need to survey legionellae in water systems to prevent legionellosis. Although the assessment of L. pneumophila in water is typically performed by culture isolation on selective media, it has several limits. For this reason, alternative tools for rapid, sensitive, and specific detection of Legionella in water samples have been proposed. In order to increase knowledge on different aspects of Legionella contamination in the water environment, this book gathers research studies related to the occurrence of Legionella in water systems of different environments; the role of different factors that can influence the Legionella contamination, as well as the advantages and disadvantages of different methodological approaches.

Research & information: general --- Biology, life sciences --- WTP 828 --- Legionella --- risk assessment plan --- water quality --- microbial analysis --- chemical analysis --- distal site positivity --- hot water return line --- chlorine --- HPC --- temperature --- water management --- free-living amoebae --- biological biocide --- cooling towers --- Legionella pneumophila --- protozoa --- Vermamoeba --- Acanthamoeba --- potable water --- hospital water --- water disinfection --- legionellosis --- Dental unit waterlines --- Legionella spp. --- risk management --- disinfection --- SBT --- molecular diversity --- hotels --- Healthcare-Associated Infections (HAIs) --- Surgical Handwashing Outlets (SHWOs) --- sensor-activated faucets --- free-living amoebae (FLA) --- virulence genes --- Willaertia magna C2c Maky --- culture media --- environmental monitoring --- quality control --- first draw --- second draw --- biofilm --- whole genome sequencing --- premise plumbing systems --- Legiolert --- ISO 11731 --- plate culture --- potable water samples --- flint --- copper --- PEX --- iron --- premise plumbing --- Legionnaires' disease --- culture --- BCYE and GVPC media --- MLVA-genotypes --- clonal complex --- West Bank --- non-tuberculous mycobacteria --- Pseudomonas --- Acinetobacter --- amoebae --- PVC --- drinking water --- ecotype --- groundwater --- environmental factors --- magnesium --- niche --- WTP 828 --- Legionella --- risk assessment plan --- water quality --- microbial analysis --- chemical analysis --- distal site positivity --- hot water return line --- chlorine --- HPC --- temperature --- water management --- free-living amoebae --- biological biocide --- cooling towers --- Legionella pneumophila --- protozoa --- Vermamoeba --- Acanthamoeba --- potable water --- hospital water --- water disinfection --- legionellosis --- Dental unit waterlines --- Legionella spp. --- risk management --- disinfection --- SBT --- molecular diversity --- hotels --- Healthcare-Associated Infections (HAIs) --- Surgical Handwashing Outlets (SHWOs) --- sensor-activated faucets --- free-living amoebae (FLA) --- virulence genes --- Willaertia magna C2c Maky --- culture media --- environmental monitoring --- quality control --- first draw --- second draw --- biofilm --- whole genome sequencing --- premise plumbing systems --- Legiolert --- ISO 11731 --- plate culture --- potable water samples --- flint --- copper --- PEX --- iron --- premise plumbing --- Legionnaires' disease --- culture --- BCYE and GVPC media --- MLVA-genotypes --- clonal complex --- West Bank --- non-tuberculous mycobacteria --- Pseudomonas --- Acinetobacter --- amoebae --- PVC --- drinking water --- ecotype --- groundwater --- environmental factors --- magnesium --- niche