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Multiple clinical trials have indicated that cancer, rather than cardiovascular illnesses, was the leading cause of death in follow-up examinations of abdominal aortic aneurysm (AAA) patients that underwent repair surgery. Also, inflammation, having a prominent role in AAA disease, has been proven to play an important role in cancer development. Therefore, a potential link could be made between AAA and cancer. We searched for micro-RNA (miRNA) candidate biomarker(s) in plasma of 15 AAA patients that developed cancer and 15 that did not. Hsa-miR-122-5p was found significantly upregulated in cancer patients compared to non-cancer patients. Further studies need to be done in order to confirm its role on bigger cohorts and to establish it as a possible therapeutic target.
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The term ‘biomedical engineering’ refers to the application of the principles and problem-solving techniques of engineering to biology and medicine. Biomedical engineering is an interdisciplinary branch, as many of the problems health professionals are confronted with have traditionally been of interest to engineers because they involve processes that are fundamental to engineering practice. Biomedical engineers employ common engineering methods to comprehend, modify, or control biological systems, and to design and manufacture devices that can assist in the diagnosis and therapy of human diseases. This Special Issue of Fluids aims to be a forum for scientists and engineers from academia and industry to present and discuss recent developments in the field of biomedical engineering. It contains papers that tackle, both numerically (Computational Fluid Dynamics studies) and experimentally, biomedical engineering problems, with a diverse range of studies focusing on the fundamental understanding of fluid flows in biological systems, modelling studies on complex rheological phenomena and molecular dynamics, design and improvement of lab-on-a-chip devices, modelling of processes inside the human body as well as drug delivery applications. Contributions have focused on problems associated with subjects that include hemodynamical flows, arterial wall shear stress, targeted drug delivery, FSI/CFD and Multiphysics simulations, molecular dynamics modelling and physiology-based biokinetic models.
risk assessment --- n/a --- stability study --- inclined ?-channel --- lab-on-a-chip --- pipette Petri dish single-cell trapping (PP-SCT) --- Abdominal Aortic Aneurysm --- drug delivery --- human biomonitoring --- abdominal aortic aneurysm --- shikonin --- hyaluronic --- Computational Fluid Dynamics (CFD) --- exposure reconstruction --- doxorubicin --- biokinetics --- blood flow --- gelation --- hyperbranched polyester --- single cell analysis --- capillary --- liposomes --- meniscus --- small vessel --- spreading --- alkannin --- hydrogel --- single-cell trapping --- drug delivery system --- microfluidics --- viscoelastic --- CFD --- FFMR --- computational fluid dynamics simulations --- biochemical processes --- hematocrit --- pressure drop --- passive trapping --- dipalmitoylphosphatidylglycerol (DPPG) --- arterial wall shear stress --- cell capture --- free-flowing film --- falling film microreactor --- non-Newtonian --- pulsatile flow --- tilt trapping --- haematocrit --- ?-PIV --- viscous --- hydrodynamics --- gravitational --- fluid–structure interaction --- blood --- physiology-based biokinetics --- simulations --- droplet spreading --- human bio-monitoring --- shear thinning --- Fluid-Structure Interaction (FSI) --- cancer --- bisphenol A --- Casson fluid --- fluid-structure interaction
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Tissue mechanics and tissue engineering are multidisciplinary and interconnected fields that are studied at multiple scales by integrating knowledge in biology, solid mechanics, fluid dynamics, finite element modeling, imaging, electronics, automation, and design. Experimental, computational, and combined approaches are often used to investigate the structure–function relationships in tissues and to understand how their mechanics and biological pathways are altered in injury, disease, or regeneration. The objective of this Special Issue is to present recent methods for the investigation of tissue mechanics and tissue engineering or for combined research between the two fields.
Technology: general issues --- Chemical engineering --- abdominal aortic aneurysm --- biaxial testing --- mechanical properties --- in vivo strain --- wall shear stress --- inflammation --- regional variations --- heterogeneity --- Goldmann tonometry --- intraocular pressure --- glaucoma --- inflation tests --- pig eyes --- corneal stiffness --- retina --- tissue engineering --- retina regeneration --- biofabrication --- 3D bioprinting --- electrospinning --- ophthalmology --- hematopoietic --- CD34 --- progenitor --- stem cells --- microencapsulation --- chitosan --- alginate --- proliferation --- megakaryocyte --- animal model --- dermal regeneration --- Integra --- Matriderm --- skin substitute --- wound healing --- n/a
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The analysis of Big Data in biomedical as well as business and financial research has drawn much attention from researchers worldwide. This book provides a platform for the deep discussion of state-of-the-art statistical methods developed for the analysis of Big Data in these areas. Both applied and theoretical contributions are showcased.
Humanities --- Social interaction --- high-dimensional --- nonlocal prior --- strong selection consistency --- estimation consistency --- generalized linear models --- high dimensional predictors --- model selection --- stepwise regression --- deep learning --- financial time series --- causal and dilated convolutional neural networks --- nuisance --- post-selection inference --- missingness mechanism --- regularization --- asymptotic theory --- unconventional likelihood --- high dimensional time-series --- segmentation --- mixture regression --- sparse PCA --- entropy-based robust EM --- information complexity criteria --- high dimension --- multicategory classification --- DWD --- sparse group lasso --- L2-consistency --- proximal algorithm --- abdominal aortic aneurysm --- emulation --- Medicare data --- ensembling --- high-dimensional data --- Lasso --- elastic net --- penalty methods --- prediction --- random subspaces --- ant colony system --- bayesian spatial mixture model --- inverse problem --- nonparamteric boostrap --- EEG/MEG data --- feature representation --- feature fusion --- trend analysis --- text mining
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The analysis of Big Data in biomedical as well as business and financial research has drawn much attention from researchers worldwide. This book provides a platform for the deep discussion of state-of-the-art statistical methods developed for the analysis of Big Data in these areas. Both applied and theoretical contributions are showcased.
high-dimensional --- nonlocal prior --- strong selection consistency --- estimation consistency --- generalized linear models --- high dimensional predictors --- model selection --- stepwise regression --- deep learning --- financial time series --- causal and dilated convolutional neural networks --- nuisance --- post-selection inference --- missingness mechanism --- regularization --- asymptotic theory --- unconventional likelihood --- high dimensional time-series --- segmentation --- mixture regression --- sparse PCA --- entropy-based robust EM --- information complexity criteria --- high dimension --- multicategory classification --- DWD --- sparse group lasso --- L2-consistency --- proximal algorithm --- abdominal aortic aneurysm --- emulation --- Medicare data --- ensembling --- high-dimensional data --- Lasso --- elastic net --- penalty methods --- prediction --- random subspaces --- ant colony system --- bayesian spatial mixture model --- inverse problem --- nonparamteric boostrap --- EEG/MEG data --- feature representation --- feature fusion --- trend analysis --- text mining
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The analysis of Big Data in biomedical as well as business and financial research has drawn much attention from researchers worldwide. This book provides a platform for the deep discussion of state-of-the-art statistical methods developed for the analysis of Big Data in these areas. Both applied and theoretical contributions are showcased.
Humanities --- Social interaction --- high-dimensional --- nonlocal prior --- strong selection consistency --- estimation consistency --- generalized linear models --- high dimensional predictors --- model selection --- stepwise regression --- deep learning --- financial time series --- causal and dilated convolutional neural networks --- nuisance --- post-selection inference --- missingness mechanism --- regularization --- asymptotic theory --- unconventional likelihood --- high dimensional time-series --- segmentation --- mixture regression --- sparse PCA --- entropy-based robust EM --- information complexity criteria --- high dimension --- multicategory classification --- DWD --- sparse group lasso --- L2-consistency --- proximal algorithm --- abdominal aortic aneurysm --- emulation --- Medicare data --- ensembling --- high-dimensional data --- Lasso --- elastic net --- penalty methods --- prediction --- random subspaces --- ant colony system --- bayesian spatial mixture model --- inverse problem --- nonparamteric boostrap --- EEG/MEG data --- feature representation --- feature fusion --- trend analysis --- text mining --- high-dimensional --- nonlocal prior --- strong selection consistency --- estimation consistency --- generalized linear models --- high dimensional predictors --- model selection --- stepwise regression --- deep learning --- financial time series --- causal and dilated convolutional neural networks --- nuisance --- post-selection inference --- missingness mechanism --- regularization --- asymptotic theory --- unconventional likelihood --- high dimensional time-series --- segmentation --- mixture regression --- sparse PCA --- entropy-based robust EM --- information complexity criteria --- high dimension --- multicategory classification --- DWD --- sparse group lasso --- L2-consistency --- proximal algorithm --- abdominal aortic aneurysm --- emulation --- Medicare data --- ensembling --- high-dimensional data --- Lasso --- elastic net --- penalty methods --- prediction --- random subspaces --- ant colony system --- bayesian spatial mixture model --- inverse problem --- nonparamteric boostrap --- EEG/MEG data --- feature representation --- feature fusion --- trend analysis --- text mining
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