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Oxidative stress and altered redox signaling have been described in a plethora of pathological conditions. Redox-active molecules can thus potentially be used to modulate the etiology/progression of such diseases. Recent advances in molecular biology and pharmacology have strengthened this area of research by providing novel mechanistic insights. This book compiles a collection of 13 articles, covering a range of topics from in vitro studies to clinical research, focused on the potential therapeutic effects of either natural or synthetic compounds, applicable to different redox-related diseases.

Research & information: general --- Biology, life sciences --- non-small cell lung cancer --- cisplatin --- apurinic/apyrimidinic endonuclease 1 --- E3330 --- cytotoxicity --- apoptosis --- migration --- invasion --- oxidative stress --- sildenafil --- DNA damage --- systemic sclerosis --- bioactivity-based assays --- cyanidin --- metabolomics --- Rubus genus --- (poly)phenols --- yeast-based discovery platform --- withanolide --- breast cancer --- mitochondrial reactive oxygen species --- peroxiredoxin 3 --- pro-oxidant therapy --- thiostrepton --- GSH --- Cysteamine --- N-acetyl cysteine --- KEAP1 --- NRF2 --- ATF4 --- adipose-derived mesenchymal stem cell --- amniotic membrane-derived mesenchymal stem cell --- antioxidants --- assisted reproductive technology --- conditioned medium --- embryo --- in vitro culture --- in vitro fertilization --- BAPN --- cell invasion --- EMT --- lysyl-oxidase --- lysyl-oxidase like 2 --- metastases --- inhibitors --- doxorubicin --- chemoresistance --- redox signaling --- nuclear factor erythroid 2-related factor 2 (Nrf2) --- cancer therapy --- hydrogen sulfide --- reactive oxygen species --- H2S donors --- cardiorenal syndrome --- thiosulfate --- selenium-enriched Enterococcus faecium --- selenium-enriched Streptococcus thermophilus --- antioxidant capacity --- glutathione reductase --- glutathione peroxidase --- CD IGS rats --- lactic acid bacteria --- verbascoside --- hypercholesterolemia --- prostate cancer --- curcumin --- carnosic acid --- cell cycle --- OxPhos --- SGK1 --- n/a