Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Mediterranean diet is a model of eating based on the traditional foods and drinks of the countries surrounding the Mediterranean Sea. The cultural and the nutritional aspects of the multisecular Mediterranean civilization include diet as a central element of health and wellbeing, including wine, if it is consumed in moderation. In recent decades, it has been promoted worldwide (UNESCO 2010) as one of the healthiest dietary patterns. The objective of this book is to bring the role of wine as part of the Mediterranean diet to light, especially through policy makers, the medical world, and vectors of images.

Humanities --- Social interaction --- apigenin --- docosahexaenoic acid --- eicosapentaenoic acid --- 7-ketocholesterol --- α-linolenic acid --- Mediterranean diet --- N2a cells --- oleic acid --- oxidative stress --- quercetin --- resveratrol. --- wine --- ethanol --- acetaldehyde --- oral cavity cancer --- carcinogenesis --- resveratrol --- polydatin --- peonidin 3-O-glucoside --- malvidin 3-O-glucoside --- quercetin 3-O-glucoside --- (+)-catechin --- (+)-taxifolin --- apoptosis --- neuronal death --- cerebellum --- polyphenols --- flavonoids --- diet --- clinical trials --- metabolites --- resveratrol butyrate ester --- butyric acid --- Steglich esterification --- prevent fat accumulation --- wine intake --- cardiovascular disease --- cancer --- dementia --- red wine extract --- AMD --- retinal cells --- ARPE-19 --- degenerative diseases --- ocular diseases --- olive oil --- alcohol --- phytochemicals --- tyrosol --- inflammatory bowel disease --- Crohn's disease --- ulcerative colitis --- inflammation --- neurodegeneration --- neuroprotection --- therapeutic targets --- pharmacology --- novel delivery system --- postovulatory aging --- oocyte quality --- reactive oxygen species

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Mediterranean diet is a model of eating based on the traditional foods and drinks of the countries surrounding the Mediterranean Sea. The cultural and the nutritional aspects of the multisecular Mediterranean civilization include diet as a central element of health and wellbeing, including wine, if it is consumed in moderation. In recent decades, it has been promoted worldwide (UNESCO 2010) as one of the healthiest dietary patterns. The objective of this book is to bring the role of wine as part of the Mediterranean diet to light, especially through policy makers, the medical world, and vectors of images.

apigenin --- docosahexaenoic acid --- eicosapentaenoic acid --- 7-ketocholesterol --- α-linolenic acid --- Mediterranean diet --- N2a cells --- oleic acid --- oxidative stress --- quercetin --- resveratrol. --- wine --- ethanol --- acetaldehyde --- oral cavity cancer --- carcinogenesis --- resveratrol --- polydatin --- peonidin 3-O-glucoside --- malvidin 3-O-glucoside --- quercetin 3-O-glucoside --- (+)-catechin --- (+)-taxifolin --- apoptosis --- neuronal death --- cerebellum --- polyphenols --- flavonoids --- diet --- clinical trials --- metabolites --- resveratrol butyrate ester --- butyric acid --- Steglich esterification --- prevent fat accumulation --- wine intake --- cardiovascular disease --- cancer --- dementia --- red wine extract --- AMD --- retinal cells --- ARPE-19 --- degenerative diseases --- ocular diseases --- olive oil --- alcohol --- phytochemicals --- tyrosol --- inflammatory bowel disease --- Crohn’s disease --- ulcerative colitis --- inflammation --- neurodegeneration --- neuroprotection --- therapeutic targets --- pharmacology --- novel delivery system --- postovulatory aging --- oocyte quality --- reactive oxygen species --- n/a --- Crohn's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Following the implementation of next-generation sequencing technologies (e.g., exome and genome sequencing) in molecular diagnostics, the majority of genetic defects underlying inherited retinal disease (IRD) can readily be identified. In parallel, opportunities to counteract the molecular consequences of these defects are rapidly emerging, providing hope for personalized medicine. ‘Classical’ gene augmentation therapy has been under study for several genetic subtypes of IRD and can be considered a safe and sometimes effective therapeutic strategy. The recent market approval of the first retinal gene augmentation therapy product (LuxturnaTM, for individuals with bi-allelic RPE65 mutations) by the FDA has not only demonstrated the potential of this specific approach, but also opened avenues for the development of other strategies. However, every gene—or even every mutation—may need a tailor-made therapeutic approach, in order to obtain the most efficacious strategy with minimal risks associated. In addition to gene augmentation therapy, other subtypes of molecular therapy are currently being designed and/or implemented, including splice modulation, DNA or RNA editing, optogenetics and pharmacological modulation. In addition, the development of proper delivery vectors has gained strong attention, and should not be overlooked when designing and testing a novel therapeutic approach. In this Special Issue, we aim to describe the current state of the art of molecular therapeutics for IRD, and discuss existing and novel therapeutic strategies, from idea to implementation, and from bench to bedside.

Research & information: general --- Biology, life sciences --- induced pluripotent stem cell (iPSC) --- clustered regularly interspaced short palindromic repeats (CRISPR) --- homology-directed repair (HDR) --- Enhanced S-Cone Syndrome (ESCS) --- NR2E3 --- AAV --- retina --- gene therapy --- dual AAV --- gold nanoparticles --- DNA-wrapped gold nanoparticles --- ARPE-19 cells --- retinal pigment epithelium --- clathrin-coated vesicles --- endosomal trafficking --- retinitis pigmentosa --- autosomal dominant --- G56R --- putative dominant negative effect --- gapmer antisense oligonucleotides --- allele-specific knockdown --- Leber congenital amaurosis and allied retinal ciliopathies --- CEP290 --- Flanders founder c.4723A &gt --- T nonsense mutation --- Cilia elongation --- spontaneous nonsense correction --- AON-mediated exon skipping --- microRNA --- photoreceptors --- rods --- cones --- bipolar cells --- Müller glia --- retinal inherited disorders --- retinal degeneration --- antisense oligonucleotides --- Stargardt disease --- inherited retinal diseases --- splicing modulation --- RNA therapy --- ABCA4 --- iPSC-derived photoreceptor precursor cells --- cyclic GMP --- apoptosis --- necrosis --- drug delivery systems --- translational medicine --- Usher syndrome --- Leber congenital amaurosis --- RPE65 --- nonprofit --- patient registry --- translational --- protein trafficking --- protein folding --- protein degradation --- chaperones --- chaperonins --- heat shock response --- unfolded protein response --- autophagy --- therapy --- IRD --- DNA therapies --- RNA therapies --- compound therapies --- clinical trials --- Retinitis Pigmentosa GTPase Regulator --- adeno-associated viral --- Retinitis Pigmentosa (RP) --- choroideremia --- REP1 --- inherited retinal disease --- treatment --- apical polarity --- crumbs complex --- fetal retina --- PAR complex --- retinal organoids --- retinogenesis --- gene augmentation --- adeno-associated virus (AAV)