Listing 1 - 9 of 9 |
Sort by
|
Choose an application
Choose an application
Choose an application
ACTINOMYCETALES --- ACTINOMYCIN --- ACTINOMYCETALES --- ACTINOMYCIN
Choose an application
SPORULATION --- ANTIMETABOLITES --- ACTINOMYCIN --- DEHYDROGENASES --- HISTOCHEMISTRY --- AUTORADIOGRAPHY --- SUCROSE --- IN VIVO ANALYSIS --- IN VITRO ANALYSIS --- GIBBERELLINS --- GROWTH REGULATORS --- PLANT HORMONES --- CARBON DIOXIDE CYCLE --- CHLOROPLASTS --- NUCLEIC ACIDS --- BUDS --- PROTEIN METABOLISM --- METABOLIC INHIBITORS --- FLOWERING --- PLANT METABOLISM --- MITOSIS --- MERISTEMS --- APICAL DOMINANCE --- VERNALISATION --- CHLOROPHYLLS --- METABOLISM --- NUCLEIC ACIDS --- SPORULATION --- ANTIMETABOLITES --- ACTINOMYCIN --- DEHYDROGENASES --- HISTOCHEMISTRY --- AUTORADIOGRAPHY --- SUCROSE --- IN VIVO ANALYSIS --- IN VITRO ANALYSIS --- GIBBERELLINS --- GROWTH REGULATORS --- PLANT HORMONES --- CARBON DIOXIDE CYCLE --- CHLOROPLASTS --- NUCLEIC ACIDS --- BUDS --- PROTEIN METABOLISM --- METABOLIC INHIBITORS --- FLOWERING --- PLANT METABOLISM --- MITOSIS --- MERISTEMS --- APICAL DOMINANCE --- VERNALISATION --- CHLOROPHYLLS --- METABOLISM --- NUCLEIC ACIDS
Choose an application
The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.
Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa
Choose an application
The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.
Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa
Choose an application
The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.
Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa
Choose an application
The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.
Medicine --- apoptosis --- fucoidan --- hepatocellular carcinoma --- reactive oxygen species --- 3-alkylpyridinium polymers --- nicotine --- nicotinic acetylcholine receptor --- non-small cell lung carcinoma --- melanoma --- sinulariolide --- proteomic --- mitochondria --- caspase cascade --- marine fungus --- sediment --- anthranilic acid --- Penicillium paneum --- cytotoxicity --- dibromotyrosine --- mitochondrial dysfunction --- oxidative stress --- topoisomerase --- epigonal organ --- bonnethead shark --- Jurkat --- tumor cell line --- hippuristanol --- PEL --- AP-1 --- STAT3 --- Akt --- colorectal cancer --- marine mollusc --- brominated indoles --- shrimp --- chemoprevention --- fatty acids --- carotenoids --- cancer --- nanoparticle --- osteosarcoma --- lung metastasis --- elisidepsin --- lipid rafts --- hydroxylated lipids --- fatty acid 2-hydroxylase --- cooperative binding --- membrane permeabilization --- marine organisms --- polysaccharides --- anticancer --- anticarcinogenic --- mechanisms of action --- fumigaclavine C --- anti-proliferation --- mitochondrial pathway --- anti-cancer --- anti-proliferative --- carotenoid --- cell cycle arrest --- fucoxanthin --- azoxymethane --- bioactive natural product --- isatin --- in vivo model --- Marthasterias glacialis L. --- palmitic acid --- ER-stress --- CHOP --- Antibody Drug Conjugates (ADCs) --- marine antitumor agents --- clinical trials --- approved antitumor agents --- AD0157 --- angiogenesis --- marine drug --- pyrrolidinedione --- secondary metabolites --- cancer preventive --- chemopreventive --- trabectedin --- plitidepsin --- tumor-associated macrophages --- tumor microenvironment --- preclinical --- anticancer immunity --- antiangiogenesis --- fascaplysin --- cyclin-dependent kinase --- small cell lung cancer --- camptothecin --- poly(ADP-ribose)-polymerase inhibitor --- breast cancer --- seaweed --- therapeutic compounds --- autophagy --- marine drugs --- autophagy inhibitors --- autophagy inducers --- macrolide --- programmed cell death --- energy stress --- araguspongine C --- c-Met --- HER2 --- gemcitabine --- pazopanib --- phase I --- safety --- soft tissue sarcoma --- pachastrissamine --- jaspine B --- carbocyclic analogue --- sphingosine kinase inhibitor --- molecular modeling --- ET-743 --- DNA minor groove binder --- soft tissue sarcoma --- chemotherapy --- bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) --- anti-metastatic activity --- cell adhesion --- β1-integrin --- FAK --- BEL-7402 cell --- triterpene glycosides --- sea cucumbers --- antitumor activities --- arrest of cell cycle --- antibacterial --- marangucyclines --- deep-sea --- Streptomyces sp. SCSIO 11594 --- LS-1 --- SNU-C5/5-FU --- TGF-β signaling --- carcinoembryonic antigen --- kalkitoxin --- Moorea producens --- mitochondria toxin --- VEGF --- angiogenesis inhibitor --- hypoxia-inducible factor-1 --- HIF-1 --- Lyngbya majuscula --- marine metabolites --- SZ-685C --- nonfunctioning pituitary adenomas --- Ecklonia cava --- phlorotannins --- dieckol --- migration --- sipholenol A --- ABC transporter --- multidrug resistance --- P-gp/ABCB1 --- BCRP/ABCG2 --- MRP1/ABCC1 --- marine natural products --- glioblastoma --- xyloketal B --- proliferation --- TRPM7 --- marine compound --- ribosomal protein genes --- snoRNA --- FAU --- RPS30 --- SNORA62 --- evolution --- Porifera --- Penicillium brevicompactum --- Brevianamide --- Mycochromenic acid derivative --- antifouling --- Caribbean sponge --- plakortide --- endoperoxide --- leukemia --- multi-drug resistant leukemia --- Sarcophyton ehrenbergi --- soft coral --- terpenes --- cembranoids --- cytotoxic activity --- molecular docking --- uveal melanoma --- oxidative stress --- virtual screening --- Topo I inhibitor --- low toxic --- natural product --- Ulva fasciata --- selenium-containing polysaccharide-protein complex --- pseudopterosin --- NF-κB --- p65 --- inflammation --- cytokine release --- IL-6 --- TNFα --- MCP-1 --- glucocorticoid receptor --- paulomycins --- Micromonospora --- antitumor --- Cantabrian Sea-derived actinobacteria --- puupehenones --- sponges --- antiangiogenic --- antitumoral --- porifera/sponge --- cancer genes --- molecular oncology --- bromophenol --- molecular mechanisms --- cell cycle --- PI3K/Akt --- p38/ERK --- ROS --- human lung cancer --- glycosaminoglycans --- antiproliferative --- heparan sulphate --- gliotoxin --- NSCLC --- adriamycin resistance --- Sepia ink polysaccharides --- antitumour --- chemosensitization --- anticoagulation --- sea anemone --- drug discovery --- endothelial cells --- RGD motif --- kunitz type inhibitor --- prostate cancer --- antioxidant --- natural marine compounds --- marine biotechnology --- microalgae --- marine sponges --- Aeroplysinin --- Isofistularin --- pheochromocytoma and paraganglioma --- metastasis --- cancer progression --- cell adhesion molecules --- integrin β1 --- hypoxia --- phycocyanin --- non-small cell lung cancer --- NF-κB signaling --- marine-derived drugs --- bioanalysis --- chromatography --- manzamine A --- epithelial-mesenchymal transition --- lung cancer --- circulating tumor cells --- signal transduction --- cisplatin --- Lampetra morii --- buccal gland --- cystatin F --- anti-angiogenesis --- cystatin superfamily --- Antimicrobial peptide (AMP) --- Tilapia piscidin 4 (TP4) --- non-small cell lung cancer (NSCLC) --- itampolin A --- FBDD --- p38α --- novel inhibitor --- tetracenomycin X --- cyclin D1 --- proteasomal degradation --- p38 --- c-JUN --- λ-carrageenan --- heparanase --- anticoagulant --- depolymerisation --- cell migration --- Aspergillus --- naphthopyrones --- endophytic fungus --- Leathesia nana --- mangrove-derived actinomycete --- ansamycins --- divergolides --- apoptosis-inducing activity --- actinomycin --- EMT --- invasion --- low molecular weight fucoidan extract --- N-Ras --- neuroblastoma-rat sarcoma --- Cancer --- programmed cell death-ligand 1 --- programmed cell death-ligand 2 --- human sarcoma cell line (HT1080 cells) --- human normal diploid fibroblast (TIG-1 cells) --- chimera --- chemical conjugation --- anticancer agent --- hybridization --- α9-nicotinic acetylcholine receptors (nAChRs) --- breast cancer cells --- αO-conotoxin GeXIVA --- targeted therapy --- gorgonian --- Leptogorgia --- humulane sesquiterpenoids --- anticancer activity --- 12-deacetyl-12-epi-scalaradial --- HeLa cells --- Nur77 --- MAPK/ERK pathway --- Mycalin A --- C15 acetogenins --- synthetic analogues --- antiproliferative activity --- A375 and HeLa cell lines --- polyoxygenated steroids --- sponge --- Haliclona gracilis --- Thalassia testudinum --- thalassiolin B --- polyphenols --- CYP1A1 --- benzo[a]pyrene --- JNK1/2 --- natural products --- synergism --- A549 cells --- cytoskeleton --- P2X7 receptor --- pollution --- anti-angiogenic --- gene expression --- HSP90 --- inhibitor --- apoptosis --- fucoidan --- hepatocellular carcinoma --- reactive oxygen species --- 3-alkylpyridinium polymers --- nicotine --- nicotinic acetylcholine receptor --- non-small cell lung carcinoma --- melanoma --- sinulariolide --- proteomic --- mitochondria --- caspase cascade --- marine fungus --- sediment --- anthranilic acid --- Penicillium paneum --- cytotoxicity --- dibromotyrosine --- mitochondrial dysfunction --- oxidative stress --- topoisomerase --- epigonal organ --- bonnethead shark --- Jurkat --- tumor cell line --- hippuristanol --- PEL --- AP-1 --- STAT3 --- Akt --- colorectal cancer --- marine mollusc --- brominated indoles --- shrimp --- chemoprevention --- fatty acids --- carotenoids --- cancer --- nanoparticle --- osteosarcoma --- lung metastasis --- elisidepsin --- lipid rafts --- hydroxylated lipids --- fatty acid 2-hydroxylase --- cooperative binding --- membrane permeabilization --- marine organisms --- polysaccharides --- anticancer --- anticarcinogenic --- mechanisms of action --- fumigaclavine C --- anti-proliferation --- mitochondrial pathway --- anti-cancer --- anti-proliferative --- carotenoid --- cell cycle arrest --- fucoxanthin --- azoxymethane --- bioactive natural product --- isatin --- in vivo model --- Marthasterias glacialis L. --- palmitic acid --- ER-stress --- CHOP --- Antibody Drug Conjugates (ADCs) --- marine antitumor agents --- clinical trials --- approved antitumor agents --- AD0157 --- angiogenesis --- marine drug --- pyrrolidinedione --- secondary metabolites --- cancer preventive --- chemopreventive --- trabectedin --- plitidepsin --- tumor-associated macrophages --- tumor microenvironment --- preclinical --- anticancer immunity --- antiangiogenesis --- fascaplysin --- cyclin-dependent kinase --- small cell lung cancer --- camptothecin --- poly(ADP-ribose)-polymerase inhibitor --- breast cancer --- seaweed --- therapeutic compounds --- autophagy --- marine drugs --- autophagy inhibitors --- autophagy inducers --- macrolide --- programmed cell death --- energy stress --- araguspongine C --- c-Met --- HER2 --- gemcitabine --- pazopanib --- phase I --- safety --- soft tissue sarcoma --- pachastrissamine --- jaspine B --- carbocyclic analogue --- sphingosine kinase inhibitor --- molecular modeling --- ET-743 --- DNA minor groove binder --- soft tissue sarcoma --- chemotherapy --- bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) --- anti-metastatic activity --- cell adhesion --- β1-integrin --- FAK --- BEL-7402 cell --- triterpene glycosides --- sea cucumbers --- antitumor activities --- arrest of cell cycle --- antibacterial --- marangucyclines --- deep-sea --- Streptomyces sp. SCSIO 11594 --- LS-1 --- SNU-C5/5-FU --- TGF-β signaling --- carcinoembryonic antigen --- kalkitoxin --- Moorea producens --- mitochondria toxin --- VEGF --- angiogenesis inhibitor --- hypoxia-inducible factor-1 --- HIF-1 --- Lyngbya majuscula --- marine metabolites --- SZ-685C --- nonfunctioning pituitary adenomas --- Ecklonia cava --- phlorotannins --- dieckol --- migration --- sipholenol A --- ABC transporter --- multidrug resistance --- P-gp/ABCB1 --- BCRP/ABCG2 --- MRP1/ABCC1 --- marine natural products --- glioblastoma --- xyloketal B --- proliferation --- TRPM7 --- marine compound --- ribosomal protein genes --- snoRNA --- FAU --- RPS30 --- SNORA62 --- evolution --- Porifera --- Penicillium brevicompactum --- Brevianamide --- Mycochromenic acid derivative --- antifouling --- Caribbean sponge --- plakortide --- endoperoxide --- leukemia --- multi-drug resistant leukemia --- Sarcophyton ehrenbergi --- soft coral --- terpenes --- cembranoids --- cytotoxic activity --- molecular docking --- uveal melanoma --- oxidative stress --- virtual screening --- Topo I inhibitor --- low toxic --- natural product --- Ulva fasciata --- selenium-containing polysaccharide-protein complex --- pseudopterosin --- NF-κB --- p65 --- inflammation --- cytokine release --- IL-6 --- TNFα --- MCP-1 --- glucocorticoid receptor --- paulomycins --- Micromonospora --- antitumor --- Cantabrian Sea-derived actinobacteria --- puupehenones --- sponges --- antiangiogenic --- antitumoral --- porifera/sponge --- cancer genes --- molecular oncology --- bromophenol --- molecular mechanisms --- cell cycle --- PI3K/Akt --- p38/ERK --- ROS --- human lung cancer --- glycosaminoglycans --- antiproliferative --- heparan sulphate --- gliotoxin --- NSCLC --- adriamycin resistance --- Sepia ink polysaccharides --- antitumour --- chemosensitization --- anticoagulation --- sea anemone --- drug discovery --- endothelial cells --- RGD motif --- kunitz type inhibitor --- prostate cancer --- antioxidant --- natural marine compounds --- marine biotechnology --- microalgae --- marine sponges --- Aeroplysinin --- Isofistularin --- pheochromocytoma and paraganglioma --- metastasis --- cancer progression --- cell adhesion molecules --- integrin β1 --- hypoxia --- phycocyanin --- non-small cell lung cancer --- NF-κB signaling --- marine-derived drugs --- bioanalysis --- chromatography --- manzamine A --- epithelial-mesenchymal transition --- lung cancer --- circulating tumor cells --- signal transduction --- cisplatin --- Lampetra morii --- buccal gland --- cystatin F --- anti-angiogenesis --- cystatin superfamily --- Antimicrobial peptide (AMP) --- Tilapia piscidin 4 (TP4) --- non-small cell lung cancer (NSCLC) --- itampolin A --- FBDD --- p38α --- novel inhibitor --- tetracenomycin X --- cyclin D1 --- proteasomal degradation --- p38 --- c-JUN --- λ-carrageenan --- heparanase --- anticoagulant --- depolymerisation --- cell migration --- Aspergillus --- naphthopyrones --- endophytic fungus --- Leathesia nana --- mangrove-derived actinomycete --- ansamycins --- divergolides --- apoptosis-inducing activity --- actinomycin --- EMT --- invasion --- low molecular weight fucoidan extract --- N-Ras --- neuroblastoma-rat sarcoma --- Cancer --- programmed cell death-ligand 1 --- programmed cell death-ligand 2 --- human sarcoma cell line (HT1080 cells) --- human normal diploid fibroblast (TIG-1 cells) --- chimera --- chemical conjugation --- anticancer agent --- hybridization --- α9-nicotinic acetylcholine receptors (nAChRs) --- breast cancer cells --- αO-conotoxin GeXIVA --- targeted therapy --- gorgonian --- Leptogorgia --- humulane sesquiterpenoids --- anticancer activity --- 12-deacetyl-12-epi-scalaradial --- HeLa cells --- Nur77 --- MAPK/ERK pathway --- Mycalin A --- C15 acetogenins --- synthetic analogues --- antiproliferative activity --- A375 and HeLa cell lines --- polyoxygenated steroids --- sponge --- Haliclona gracilis --- Thalassia testudinum --- thalassiolin B --- polyphenols --- CYP1A1 --- benzo[a]pyrene --- JNK1/2 --- natural products --- synergism --- A549 cells --- cytoskeleton --- P2X7 receptor --- pollution --- anti-angiogenic --- gene expression --- HSP90 --- inhibitor
Choose an application
The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.
apoptosis --- fucoidan --- hepatocellular carcinoma --- reactive oxygen species --- 3-alkylpyridinium polymers --- nicotine --- nicotinic acetylcholine receptor --- non-small cell lung carcinoma --- melanoma --- sinulariolide --- proteomic --- mitochondria --- caspase cascade --- marine fungus --- sediment --- anthranilic acid --- Penicillium paneum --- cytotoxicity --- dibromotyrosine --- mitochondrial dysfunction --- oxidative stress --- topoisomerase --- epigonal organ --- bonnethead shark --- Jurkat --- tumor cell line --- hippuristanol --- PEL --- AP-1 --- STAT3 --- Akt --- colorectal cancer --- marine mollusc --- brominated indoles --- shrimp --- chemoprevention --- fatty acids --- carotenoids --- cancer --- nanoparticle --- osteosarcoma --- lung metastasis --- elisidepsin --- lipid rafts --- hydroxylated lipids --- fatty acid 2-hydroxylase --- cooperative binding --- membrane permeabilization --- marine organisms --- polysaccharides --- anticancer --- anticarcinogenic --- mechanisms of action --- fumigaclavine C --- anti-proliferation --- mitochondrial pathway --- anti-cancer --- anti-proliferative --- carotenoid --- cell cycle arrest --- fucoxanthin --- azoxymethane --- bioactive natural product --- isatin --- in vivo model --- Marthasterias glacialis L. --- palmitic acid --- ER-stress --- CHOP --- Antibody Drug Conjugates (ADCs) --- marine antitumor agents --- clinical trials --- approved antitumor agents --- AD0157 --- angiogenesis --- marine drug --- pyrrolidinedione --- secondary metabolites --- cancer preventive --- chemopreventive --- trabectedin --- plitidepsin --- tumor-associated macrophages --- tumor microenvironment --- preclinical --- anticancer immunity --- antiangiogenesis --- fascaplysin --- cyclin-dependent kinase --- small cell lung cancer --- camptothecin --- poly(ADP-ribose)-polymerase inhibitor --- breast cancer --- seaweed --- therapeutic compounds --- autophagy --- marine drugs --- autophagy inhibitors --- autophagy inducers --- macrolide --- programmed cell death --- energy stress --- araguspongine C --- c-Met --- HER2 --- gemcitabine --- pazopanib --- phase I --- safety --- soft tissue sarcoma --- pachastrissamine --- jaspine B --- carbocyclic analogue --- sphingosine kinase inhibitor --- molecular modeling --- ET-743 --- DNA minor groove binder --- chemotherapy --- bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) --- anti-metastatic activity --- cell adhesion --- β1-integrin --- FAK --- BEL-7402 cell --- triterpene glycosides --- sea cucumbers --- antitumor activities --- arrest of cell cycle --- antibacterial --- marangucyclines --- deep-sea --- Streptomyces sp. SCSIO 11594 --- LS-1 --- SNU-C5/5-FU --- TGF-β signaling --- carcinoembryonic antigen --- kalkitoxin --- Moorea producens --- mitochondria toxin --- VEGF --- angiogenesis inhibitor --- hypoxia-inducible factor-1 --- HIF-1 --- Lyngbya majuscula --- marine metabolites --- SZ-685C --- nonfunctioning pituitary adenomas --- Ecklonia cava --- phlorotannins --- dieckol --- migration --- sipholenol A --- ABC transporter --- multidrug resistance --- P-gp/ABCB1 --- BCRP/ABCG2 --- MRP1/ABCC1 --- marine natural products --- glioblastoma --- xyloketal B --- proliferation --- TRPM7 --- marine compound --- ribosomal protein genes --- snoRNA --- FAU --- RPS30 --- SNORA62 --- evolution --- Porifera --- n/a --- Penicillium brevicompactum --- Brevianamide --- Mycochromenic acid derivative --- antifouling --- Caribbean sponge --- plakortide --- endoperoxide --- leukemia --- multi-drug resistant leukemia --- Sarcophyton ehrenbergi --- soft coral --- terpenes --- cembranoids --- cytotoxic activity --- molecular docking --- uveal melanoma --- virtual screening --- Topo I inhibitor --- low toxic --- natural product --- Ulva fasciata --- selenium-containing polysaccharide-protein complex --- pseudopterosin --- NF-κB --- p65 --- inflammation --- cytokine release --- IL-6 --- TNFα --- MCP-1 --- glucocorticoid receptor --- paulomycins --- Micromonospora --- antitumor --- Cantabrian Sea-derived actinobacteria --- puupehenones --- sponges --- antiangiogenic --- antitumoral --- porifera/sponge --- cancer genes --- molecular oncology --- bromophenol --- molecular mechanisms --- cell cycle --- PI3K/Akt --- p38/ERK --- ROS --- human lung cancer --- glycosaminoglycans --- antiproliferative --- heparan sulphate --- gliotoxin --- NSCLC --- adriamycin resistance --- Sepia ink polysaccharides --- antitumour --- chemosensitization --- anticoagulation --- sea anemone --- drug discovery --- endothelial cells --- RGD motif --- kunitz type inhibitor --- prostate cancer --- antioxidant --- natural marine compounds --- marine biotechnology --- microalgae --- marine sponges --- Aeroplysinin --- Isofistularin --- pheochromocytoma and paraganglioma --- metastasis --- cancer progression --- cell adhesion molecules --- integrin β1 --- hypoxia --- phycocyanin --- non-small cell lung cancer --- NF-κB signaling --- marine-derived drugs --- bioanalysis --- chromatography --- manzamine A --- epithelial–mesenchymal transition --- lung cancer --- circulating tumor cells --- signal transduction --- cisplatin --- Lampetra morii --- buccal gland --- cystatin F --- anti-angiogenesis --- cystatin superfamily --- Antimicrobial peptide (AMP) --- Tilapia piscidin 4 (TP4) --- non-small cell lung cancer (NSCLC) --- itampolin A --- FBDD --- p38α --- novel inhibitor --- tetracenomycin X --- cyclin D1 --- proteasomal degradation --- p38 --- c-JUN --- λ-carrageenan --- heparanase --- anticoagulant --- depolymerisation --- cell migration --- Aspergillus --- naphthopyrones --- endophytic fungus --- Leathesia nana --- mangrove-derived actinomycete --- ansamycins --- divergolides --- apoptosis-inducing activity --- actinomycin --- EMT --- invasion --- low molecular weight fucoidan extract --- N-Ras --- neuroblastoma-rat sarcoma --- Cancer --- programmed cell death-ligand 1 --- programmed cell death-ligand 2 --- human sarcoma cell line (HT1080 cells) --- human normal diploid fibroblast (TIG-1 cells) --- chimera --- chemical conjugation --- anticancer agent --- hybridization --- α9-nicotinic acetylcholine receptors (nAChRs) --- breast cancer cells --- αO-conotoxin GeXIVA --- targeted therapy --- gorgonian --- Leptogorgia --- humulane sesquiterpenoids --- anticancer activity --- 12-deacetyl-12-epi-scalaradial --- HeLa cells --- Nur77 --- MAPK/ERK pathway --- Mycalin A --- C15 acetogenins --- synthetic analogues --- antiproliferative activity --- A375 and HeLa cell lines --- polyoxygenated steroids --- sponge --- Haliclona gracilis --- Thalassia testudinum --- thalassiolin B --- polyphenols --- CYP1A1 --- benzo[a]pyrene --- JNK1/2 --- natural products --- synergism --- A549 cells --- cytoskeleton --- P2X7 receptor --- pollution --- anti-angiogenic --- gene expression --- HSP90 --- inhibitor --- epithelial-mesenchymal transition
Listing 1 - 9 of 9 |
Sort by
|