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Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a “stand alone” analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications.

Research & information: general --- Chemistry --- Analytical chemistry --- tyrosine kinase inhibitors --- chloranilic acid --- charge-transfer reaction --- 96-microwell spectrophotometric assay --- high-throughput pharmaceutical analysis --- biogenic amines --- Lycium barbarum L. --- HPLC --- derivatization --- amino acids --- esterification --- GC–MS --- pentafluoropropionic anhydride --- stability --- toluene --- pigment --- linseed oil --- derivatisation --- quantification --- P/S ratio --- A/P ratio --- ∑D --- GC-MS --- ureide --- BSTFA --- creatine --- creatinine --- silylation --- TMS --- validation --- low-molecular-weight thiols --- human serum albumin --- α-lipoic acid --- blood plasma --- monobromobimane --- reduction --- sodium borohydride --- high-performance liquid chromatography --- fluorescence detection --- taurine --- glutamine --- clams --- high-resolution mass spectrometry --- nerve agents --- methylation --- chemical warfare agents --- sarin --- Novichoks --- 2-naphthalenethiol --- sulforaphane --- HPLC-UV/Vis --- pharmacokinetics --- acetonitrile-related adducts --- acetylenic lipids --- double and triple bond localization --- in-source derivatization --- mass spectrometry --- acetazolamide --- carbonic anhydrase --- enhancement --- inhibition --- pentafluorobenzyl bromide --- chiral metabolomics --- rice water --- d-amino acids --- enantiomer separation --- dimethyl labeling --- homocysteine thiolactone --- homocysteine --- zone fluidics --- o-phthalaldehyde --- fluorosurfactant-modified gold nanoparticles