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Phytochemistry. Phytobiochemistry --- 577.322 --- 577.112 --- 581.1 --- Physics and physical chemistry of proteins --- Proteins --- Plant physiology --- 581.1 Plant physiology --- 577.112 Proteins --- 577.322 Physics and physical chemistry of proteins

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Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension of classical protein chemistry, owing much of its maturation to prior contributions. Unfortunately, this debt is not always evident in current literature.

**The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application,** in providing a different perspective than other reviews, strengthens the connection between solution protein chemistry and proteomic technology. Towards this end, Roger Lundblad, a long-time leader in protein chemistry and a scientist who has worked in both academics and industry**,** brings together some seemingly disparate areas into a single volume. Discussing analytical proteomics, expression proteomics, and clinical proteomics (biomarker identification), he provides coverage that is uniquely rich in detail.

Lundblad applies this detail to sample preparation for proteomic analysis, including preparation from blood and tissues. He also presents specifics on the prefractionation of samples used to identify specific subproteomes such as phosphoproteomes and glycoproteomes. Comprehensive reviews are provided covering the chemical modification of proteins, including its use for chemical proteomics. Special attention is given to challenges that impede the identification, validation, and development of biomarkers into clinically useful diagnostic analytes.

A bestselling author, Lundblad utilizes classical protein chemistry literature in providing an intellectual basis for proteomics that merges current concepts with the existing literature, while providing the technical detail necessary for the effective commercialization of proteomics.


General biochemistry --- Molecular biology --- Clinical chemistry --- Biochemical engineering --- biochemistry --- spectrometry --- massaspectrometrie --- protein-engineering --- proteomics --- biochemie --- spectrometrie --- Proteins --- Proteomics --- 577.322 --- Eiwitten --- Proteoom --- Chemical modification of proteins --- Protein engineering --- 577.322 Physics and physical chemistry of proteins --- Physics and physical chemistry of proteins --- Chemical modification

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This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

577.322 --- 577.323 --- Molecular dynamics --- Dynamics, Molecular --- Physics and physical chemistry of proteins --- Physics and physical chemistry of nucleic acids --- Molecular dynamics. --- 577.323 Physics and physical chemistry of nucleic acids --- 577.322 Physics and physical chemistry of proteins --- chemical structure --- Acides nucléiques --- Dynamique moleculaire --- Moleculaire dynamica --- Nucleïnezuren --- Proteïnen --- Zuren [Nucleïne] --- Biosynthese. --- Nucleinezuren. --- Nucleic acids --- Proteins --- #WSCH:FYS3 --- #WSCH:MODS --- 577.3 --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Polynucleotides --- Dynamics --- 577.3 Physical and physicochemical bases of life. Biophysics. Biophysical chemistry in general --- Physical and physicochemical bases of life. Biophysics. Biophysical chemistry in general --- General biophysics --- Eiwitten. --- Moleculaire biologie. --- Nucleic acids. --- Proteins. --- proteins --- Molecular biology --- genetics --- Dynamique chimique