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The biological chemistry of iron : a look at the metabolism of iron and its subsequent uses in living organisms
Authors: ---
ISBN: 9027714444 9400978847 9400978820 Year: 1982 Publisher: Dordrecht : D. Reidel,


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Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
Author:
ISBN: 331900302X 3319003038 Year: 2013 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Abstract

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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