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Cet ouvrage collectif, re´unissant chercheurs et cliniciens, est le fruit d'un forum de la Socie´te´ de Neuropsychologie de Langue Franc¸aise. L'e´volution de la recherche, ces quinze dernie`res anne´es, a bouleverse´ nos connaissances sur les maladies neurode´ge´ne´ratives. Le de´veloppement conside´rable des techniques d'imagerie ce´re´brale, l'ave`nement des biomarqueurs, et une connaissance de plus en plus fine de la neuropsychologie ont conduit a` la ne´cessite´ d'actualiser les crite`res diagnostiques pour certaines de ces affections. La dernie`re version du Manuel diagnostique et statistique des troubles mentaux (DSM-5) propose elle aussi quelques nouveaute´s, en introduisant notamment le concept de trouble neurocognitif majeur ou le´ger repris dans ce volume. Entre mises au point et remises en question, cet ouvrage aborde les aspects cliniques, neuropsychologiques, physiopathologiques et the´rapeutiques des principales e´tiologies de´mentielles comme la maladie d'Alzheimer, mais e´galement les de´mences cortico-sous-corticales, les de´ge´ne´rescences lobaires fronto-temporales, ou encore les de´mences vasculaires.

Clinical neuropsychology.

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Cerebrospinal fluid is an essential, clear, and colorless liquid essential for maintaining homeostasis of the brain and neuronal functioning. Its secretion in adults ranges from 400 to 600 ml per day and it is renewed about four or five times daily. Cerebrospinal fluid is mainly reabsorbed from arachnoid granulations. Any disruption in this well-regulated system, such as overproduction, decreased absorption, or obstruction, could lead to hydrocephalus. This book contains essential knowledge about cerebrospinal fluid anatomy and physiology, pathologies related to cerebrospinal fluid, and treatment strategies for cerebrospinal fluid disorders.

Clinical neuropsychology.

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In this research binocular rivalry is used as a tool to investigate different aspects of visual and multisensory perception. Several experiments presented here demonstrated that touch speci cally interacts with vision during binocular rivalry and that the interaction likely occurs at early stages of visual processing, probably V1 or V2. Another line of research also presented here demonstrated that human adult visual cortex retains an unexpected high degree of experience-dependent plasticity by showing that a brief period of monocular deprivation produced important perceptual consequences on the dynamics of binocular rivalry, reflecting a homeostatic plasticity. In summary, this work shows that binocular rivalry is a powerful tool to investigate different aspects of visual perception and can be used to reveal unexpected properties of early visual cortex.

Clinical neuropsychology.

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Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a major monogenic neurocutaneous disorder. The NF1 gene encodes the protein neurofibromin whose dysfunction promotes tumorigenesis in central and peripheral neuronal tissues. In addition to inducing the formation of cutaneous pigmented lesions or neurofibromas, NF1 affects multiple organ systems, resulting in neurological and psychiatric disorders, orthopedic conditions, and impaired endocrine functions. This book examines the fundamental, clinical, and basic aspects of NF1 over three sections and nine chapters. Topics addressed include bone lesions in children with NF1, diffuse neurofibromatous tissue, seizures in adults with NF1, Ras-GAP function of neurofibromin, endocrine disorders characteristic of NF1, and more.

Clinical neuropsychology.

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In this research binocular rivalry is used as a tool to investigate different aspects of visual and multisensory perception. Several experiments presented here demonstrated that touch speci cally interacts with vision during binocular rivalry and that the interaction likely occurs at early stages of visual processing, probably V1 or V2. Another line of research also presented here demonstrated that human adult visual cortex retains an unexpected high degree of experience-dependent plasticity by showing that a brief period of monocular deprivation produced important perceptual consequences on the dynamics of binocular rivalry, reflecting a homeostatic plasticity. In summary, this work shows that binocular rivalry is a powerful tool to investigate different aspects of visual perception and can be used to reveal unexpected properties of early visual cortex.

Clinical neuropsychology.