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Laboratory animals --- Animal experimentation. --- Experimentation on animals --- Zoopery --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Research --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation

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This book addresses how to improve laboratory animal care and use while also characterizing the current state of the industry and speculating on its long-term future. The proper care and use of laboratory animals is critically important to scientists and those who depend on data generated from these animals, such as physicians, patients and their families, consumers, federal and non-profit research funding entities, health advocacy organizations, FDA, EPA and other regulatory approval agencies, and companies that invest billions of research and development dollars for creating new diagnostics, drugs, vaccines, and medical devices. this publication offers analysis from a field expert with a wealth of experience and presents new approaches for further advances in the field.--

Laboratory animals. --- Biological laboratories --- Management. --- Laboratories --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation

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This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.

Oncology. --- Oncology  . --- Laboratory animals. --- Cancer Research. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Tumors

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"In order to better understand the critical issues pertaining to the concept of performance standards for laboratory animal use, the Institute for Laboratory Animal Research Roundtable on Science and Welfare in Laboratory Animal Use held a public workshop on April 20-21, 2015. The purpose of the workshop was to promote the appropriate and responsible care of animals in research, to provide a balanced and civil forum for discussion and collaboration, and to help build transparency and trust among stakeholders. Participants addressed the challenges of defining, developing, implementing, assessing, and validating performance standards to ensure "optimal practices, management, and operations." This report summarizes the presentations and discussions from the workshop"--Publisher's description.

Laboratory animals --- Animal welfare --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- United States.

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A volume in the American College of Laboratory Animal Medicine series, this second edition has over 40% new material, including the addition of six new topics and many others that are completely rewritten. The book comprehensively covers the biological and disease aspects of laboratory animal medicine while examining other aspects such as the biohazards associated with the use of animal experimentation and factors complicating the bioethics of animal research.

Animals --- Laboratory animals --- Veterinary medicine --- Animaux --- Animaux de laboratoire --- Médecine vétérinaire --- Diseases --- Maladies --- Médecine vétérinaire --- Laboratory animals. --- Diseases. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation