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oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar­ macological targets in the treatment of a variety of disorders, such as epi­ lepsy, hypertension, and pain. Voltage-gated calcium channels have there­ fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl­ edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac­ tivity, the book delves into a provocative overview of the history of the cal­ cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat­ ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.

Calcium channels. --- Ion channels. --- Channels, Ion --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Channels, Calcium --- Ion channels --- Cytology. --- Life sciences. --- Neurosciences. --- Human physiology. --- Toxicology. --- Cell Biology. --- Life Sciences, general. --- Biological and Medical Physics, Biophysics. --- Human Physiology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Human biology --- Medical sciences --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Biosciences --- Sciences, Life --- Science --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Toxicology --- Cell biology. --- Biophysics. --- Biological physics. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Biological physics --- Physics --- Physiological effect

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Calcium channels. --- RNA editing. --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- Genetic regulation --- Channels, Calcium --- Ion channels

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In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.

Nervous system. --- Neurosciences. --- Nervous System --- Ion Channels --- Interactome --- cellular signaling --- Protein complexes

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In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.

Nervous system. --- Neurosciences. --- Nervous System --- Ion Channels --- Interactome --- cellular signaling --- Protein complexes --- Nervous System --- Ion Channels --- Interactome --- cellular signaling --- Protein complexes