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Virus diseases --- Myelocytic leukemia --- Hematopoietic stem cell disorders --- Bone marrow cells

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.

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Bridging the gap between science and clinical practice, The Bethesda Handbook of Clinical Hematology, Fourth Edition , provides concise, up-to-date coverage of 'need to know' information on the diagnosis and treatment of blood and bone marrow disorders. Written by nationally recognized experts and senior fellows at the National Institutes of Health, and at leading research institutions throughout the United States, this essential pocket reference is logically organized by disease category and features a reader-friendly format that includes tables, algorithms, illustrations, and bulleted lists that highlight key information. Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases. Contains new information on diagnosis, treatment and management of myelodysplastic and myeloproliferative disorders; leukemias and lymphomas; disorders of hemostasis and thrombosis. Features new diagnostic and treatment strategies, updated references, and revised information throughout. Ideal for the student, resident, or fellow on a hematology or oncology service, as well as the internist, hospitalist, family practitioner, and pediatrician who sees patients with blood diseases. Perfect as an everyday reference or for board review.

Blood --- Anemia. --- Hematologic Diseases --- Blood --- Hematology --- Vitamin B 12 Deficiency --- Iron Deficiencies --- Sang --- Diseases. --- Physiology: Blood Physiological Phenomena. --- standards --- pathology --- prevention & control --- Maladies.

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