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Omics technologies such as proteomics, genomics, and metabolomics are widely applied for the identification and characterization of new molecular signatures. However, molecular profiling that makes it possible to understand neurodegenerative diseases has been relatively insufficient. Brain diseases such as neurodegenerative diseases and emotional disorders need integrative understanding which draws on a more reliable hypothesis for pathology, which can be accomplished via in-depth study of molecular information. Recently, multi-omics technologies have been eagerly applied to a diverse range of diseases. As this includes multiple molecular profiling, metadata, and Big Data processing with informatics and computer science, it is possible to provide new macroscopic and microscopic insights in order to better understand diseases. This Special Issue will introduce recent technological advances in multi-omics and the application of omics technology to brain diseases.

Research & information: general --- schizophrenia --- abnormal behavior gene set --- region --- differentially expressed genes --- de novo mutation --- copy number variant --- SIDS --- newborn infant --- genetic polymorphism --- neurotransmitter --- epigenetics --- epigenome --- zinc finger domain --- zinc finger motif --- zinc finger proteins --- zinc metalloproteins --- flow infusion analysis --- chloride adducts --- ceramides --- sphingolipids --- glycerophosphocholines --- human brain --- NAD+ --- nicotinamide --- ageing --- plasma --- biomarker --- CNV --- PPI --- spatiotemporal network --- chromosome 22q11.21 --- DGCR8 --- Orthosiphon stamineus --- plant-derived proteins --- neuroprotective --- SH-SY5Y cell model --- hydrogen peroxide --- CSF --- miRNAs --- neurological diseases --- OpenArray --- morphine --- withdrawal --- brain --- proteomics --- synaptic plasticity --- Alzheimer’s disease --- microfluidics --- lab-on-chip --- 3D culture --- organ-on-chip --- n/a --- Alzheimer's disease

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Omics technologies such as proteomics, genomics, and metabolomics are widely applied for the identification and characterization of new molecular signatures. However, molecular profiling that makes it possible to understand neurodegenerative diseases has been relatively insufficient. Brain diseases such as neurodegenerative diseases and emotional disorders need integrative understanding which draws on a more reliable hypothesis for pathology, which can be accomplished via in-depth study of molecular information. Recently, multi-omics technologies have been eagerly applied to a diverse range of diseases. As this includes multiple molecular profiling, metadata, and Big Data processing with informatics and computer science, it is possible to provide new macroscopic and microscopic insights in order to better understand diseases. This Special Issue will introduce recent technological advances in multi-omics and the application of omics technology to brain diseases.

Research & information: general --- schizophrenia --- abnormal behavior gene set --- region --- differentially expressed genes --- de novo mutation --- copy number variant --- SIDS --- newborn infant --- genetic polymorphism --- neurotransmitter --- epigenetics --- epigenome --- zinc finger domain --- zinc finger motif --- zinc finger proteins --- zinc metalloproteins --- flow infusion analysis --- chloride adducts --- ceramides --- sphingolipids --- glycerophosphocholines --- human brain --- NAD+ --- nicotinamide --- ageing --- plasma --- biomarker --- CNV --- PPI --- spatiotemporal network --- chromosome 22q11.21 --- DGCR8 --- Orthosiphon stamineus --- plant-derived proteins --- neuroprotective --- SH-SY5Y cell model --- hydrogen peroxide --- CSF --- miRNAs --- neurological diseases --- OpenArray --- morphine --- withdrawal --- brain --- proteomics --- synaptic plasticity --- Alzheimer's disease --- microfluidics --- lab-on-chip --- 3D culture --- organ-on-chip --- schizophrenia --- abnormal behavior gene set --- region --- differentially expressed genes --- de novo mutation --- copy number variant --- SIDS --- newborn infant --- genetic polymorphism --- neurotransmitter --- epigenetics --- epigenome --- zinc finger domain --- zinc finger motif --- zinc finger proteins --- zinc metalloproteins --- flow infusion analysis --- chloride adducts --- ceramides --- sphingolipids --- glycerophosphocholines --- human brain --- NAD+ --- nicotinamide --- ageing --- plasma --- biomarker --- CNV --- PPI --- spatiotemporal network --- chromosome 22q11.21 --- DGCR8 --- Orthosiphon stamineus --- plant-derived proteins --- neuroprotective --- SH-SY5Y cell model --- hydrogen peroxide --- CSF --- miRNAs --- neurological diseases --- OpenArray --- morphine --- withdrawal --- brain --- proteomics --- synaptic plasticity --- Alzheimer's disease --- microfluidics --- lab-on-chip --- 3D culture --- organ-on-chip

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The ongoing demographic changes will bring about a substantial shift in the size and the age composition of the population, which will have significant impact on the global economy. Despite potentially grave consequences, demographic changes usually do not take center stage in many macroeconomic policy discussions or debates. This paper illustrates how demographic variables move over time and analyzes how they influence macroeconomic variables such as economic growth, inflation, savings and investment, and fiscal balances, from an empirical perspective. Based on empirical findings—particularly regarding inflation—we discuss their implications on macroeconomic policies, including monetary policy. We also highlight the need to consider the interactions between population dynamics and macroeconomic variables in macroeconomic policy decisions.

Demography --- Macroeconomics --- Inflation (Finance) --- Economic policy --- Monetary policy --- Economic nationalism --- Economic planning --- National planning --- State planning --- Economics --- Planning --- National security --- Social policy --- Historical demography --- Social sciences --- Population --- Vital statistics --- Demographic Trends, Macroeconomic Effects, and Forecasts --- Price Level --- Inflation --- Deflation --- Macroeconomics: Consumption --- Saving --- Wealth --- Demographic Economics: General --- Economics of the Elderly --- Economics of the Handicapped --- Non-labor Market Discrimination --- Health: General --- Population & demography --- Population & migration geography --- Health economics --- Demographic change --- Population and demographics --- Population growth --- Aging --- Health --- Demographic transition --- Population aging --- Japan

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The book is the first attempt to offer a holistic and integrated exploration of the political-economic framework underpinning economic regionalism. In doing so it provides a much-needed contribution to the literature on international political economy, international relations and Asian political economy in relation to economic regionalism. The existing literature provides broad generalizations and limited discussion on economic integration (i.e. free trade agreements, FTA) with most analyses of regionalism generally contained to the field of economics with a focus on the welfare implications of FTAs, both for participating countries and the world as a whole. Readers of this book can view economic regionalism from a variety of perspectives with input from Chinese, Japanese and Korean research institutes, business and industry groups, and government officials. Drawing on the considerable country experience and expertise of the authors, the book attempts to unravel the paradox of the market-driven economic globalization process (regionalism) and address a serious gap in the current literature relating to the political-economic characteristics and strategies of China, Japan and Korea in relation to economic regionalism.

Regional economics --- Regionalism --- East Asia --- Economic integration.