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This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.
Neurosciences. --- Neurobiology. --- Cell biology. --- Biomedical engineering. --- Neuropsychology. --- Neurology . --- Cell Biology. --- Biomedical Engineering/Biotechnology. --- Neurology. --- Medicine --- Nervous system --- Neuropsychiatry --- Neurophysiology --- Psychophysiology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Cell biology --- Cellular biology --- Biology --- Cells --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Optogenetics. --- Genetic engineering --- Optical engineering
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The subject of optogenetics is comprehensively covered in this book, including physical, chemical, and biological topics of light-sensing proteins and their application in biological systems, particularly in neuroscience and medicine and the related opto-electronics. Optogenetics is a new technology that combines genetics and optics. It enables one to manipulate or measure the function of identified cells or neurons in a tissue by light with an accuracy in the range of milliseconds, even in a freely moving animal. Optogenetics has already become a powerful tool for revealing the neural mechanisms underlying behavior and analyzing various physiological phenomena. It is also expected to become useful for treating neural dysfunctions such as Parkinson disease and for the development of a brain–machine interface. This book should be read by any scientist or student performing research in any way related to optogenetics. As a milestone publication on optogenetics, this book will serve as a compass for any researcher, from beginners to experts, to explore this uncharted world.
Biomedicine. --- Neurosciences. --- Cell Biology. --- Protein Science. --- Medicine. --- Biochemistry. --- Cytology. --- Médecine --- Neurosciences --- Biochimie --- Cytologie --- Medicine --- Health & Biological Sciences --- Neurology --- Optogenetics. --- Proteins. --- Cell biology. --- Genetic engineering --- Optical engineering --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Composition --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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The subject of optogenetics is comprehensively covered in this book, including physical, chemical, and biological topics of light-sensing proteins and their application in biological systems, particularly in neuroscience and medicine and the related opto-electronics. Optogenetics is a new technology that combines genetics and optics. It enables one to manipulate or measure the function of identified cells or neurons in a tissue by light with an accuracy in the range of milliseconds, even in a freely moving animal. Optogenetics has already become a powerful tool for revealing the neural mechanisms underlying behavior and analyzing various physiological phenomena. It is also expected to become useful for treating neural dysfunctions such as Parkinson disease and for the development of a brain–machine interface. This book should be read by any scientist or student performing research in any way related to optogenetics. As a milestone publication on optogenetics, this book will serve as a compass for any researcher, from beginners to experts, to explore this uncharted world.
Chemical structure --- Chemistry --- Histology. Cytology --- Neuropathology --- neurologie --- protein-engineering --- cytologie --- histologie --- eiwitten --- proteïnen
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Psychology --- Histology. Cytology --- Neuropathology --- Biotechnology --- neurologie --- hersenen --- biotechnologie --- cytologie --- neuropsychologie --- histologie
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This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a "must read" for all involved in research in any way related to optogenetics.
Psychology --- Histology. Cytology --- Neuropathology --- Biotechnology --- neurologie --- hersenen --- biotechnologie --- cytologie --- neuropsychologie --- histologie
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Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and
Electrooptical devices. --- Neural networks (Neurobiology) --- Neural transmission. --- Physiological optics. --- Optics, Physiological --- Optics --- Vision --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Neural circuitry --- Neurophysiology --- Neurotransmitters --- Biological neural networks --- Nets, Neural (Neurobiology) --- Networks, Neural (Neurobiology) --- Neural nets (Neurobiology) --- Cognitive neuroscience --- Neurobiology --- Electric apparatus and appliances --- Optical instruments --- Integrated optics --- Optoelectronic devices --- Biophysics. --- Genetic Engineering. --- Neuroscience. --- Optics. --- Vision Restoration.
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