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Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recent years, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is the perturbations of these reactions which pose the most intriguing therapeutic challenges.

Free radicals (Chemistry) --- Immunopharmacology. --- Pharmacoimmunology --- Immunology --- Pharmacology --- Immunotoxicology --- Radicals (Chemistry) --- Free radical reactions

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Because inflammation is involved in many chronic human diseases, its proper understanding may provide important clues to new therapeutic targets. In Inflammation Protocols, highly skilled experimenters present key techniques for the multidisciplinary study of inflammation in such conditions as inflammatory bowel disease, rheumatoid arthritis, renal disease, and cardiovascular disease. Described in step-by-step detail to ensure experimental success, the techniques are focused on the research and development of potential new antiinflammatory drugs in active target areas. The protocols are suitable for many current areas of drug discovery research, including transcription factors, cytokines, adhesion molecules, cyclooxygenase-2 (COX-2) inhibitors, free radicals, nitric oxide synthases, complement activation, angiogenesis, wound healing, immune rejection, and metalloproteinases. The methods provide in vitro systems for studying inflammation, in vivo models, and relevant pharmacodynamic measurements for the assessment of antiinflammatory compounds. Each protocol contains notes about potential pitfalls and tips on how to avoid failure. Overview chapters at the start of each section review the significance and potential limitations of the protocols presented. Cutting-edge and highly practical, Inflammation Protocols offers experimental and clinical researchers a premier collection of readily reproducible techniques not only for evaluating inflammatory disease processes, but also for the discovery of new drugs for treating chronic human inflammatory diseases today.

Inflammation --- Anti-inflammatory agents --- Mediators --- Anti-inflammatory agents -- Laboratory manuals. --- Electronic books. -- local. --- Inflammation -- Laboratory manuals. --- Inflammation -- Mediators -- Laboratory manuals. --- Anti-Inflammatory Agents --- Pathologic Processes --- Therapeutic Uses --- Pharmacologic Actions --- Pathological Conditions, Signs and Symptoms --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Pathology --- Medicine --- Health & Biological Sciences --- Anti-inflammatories --- Antiinflammatory agents --- Antiphlogistics --- Antipyretics --- Inflammatory process --- Immunology. --- Immunobiology --- Life sciences --- Serology --- Inflammation - Laboratory manuals --- Inflammation - Mediators - Laboratory manuals --- Anti-inflammatory agents - Laboratory manuals

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Nature endows us with a treasure chest of Green Gold full of amazing substances we can use as part of our daily life. Many of these compounds are ‘redox-active’, and hence able to trigger or interfere with numerous biological processes which occur in our own body, in animals, bacteria, fungi and plants. The resulting, often rather astonishing events witnessed once such natural products meet biological systems, are omnipresent. We protect our body from damage with the help of (redox-active) vitamins, use redox-active antioxidants on our skin to look better and younger and even try to slow down the natural ageing process by stimulating sirtuins and meddling with epigenetic processes. We habitually consume functional foods enriched in polyphenols, for instance in form of grape seed flour, use redox-active plant metabolites as medicines and also spray them on our roses in the hope to improve our own life and the ones of our beloved shrubs. Amazingly, whilst such natural products are all around and also in us, we still do not fully understand how these compounds actually work. This book therefore attempts to resolve some of the mysteries and riddles associated with such products. Written by more than thirty international experts from academia and industry, the book places a firm focus on modern, forward-looking developments in this field and considers such natural products from various angles, from their isolation and characterization all along to product development, licensing and commercialization. Throughout, the reader will be confronted with a medley of modern approaches which enable the fast and efficient identification and isolation of new natural products, help to elucidate their biochemical mode(s) of action and form the basis for their practical uses in Medicine, Cosmetics, Agriculture, Industry and as functional foods. Emerging new techniques, such as extraction and purification methods based on supercritical fluids, cutting-edge mass spectrometry for rapid identification, nanocrystals to improve bioavailability, synthetic chemistry to create hybrid molecules and product development to arrive at commercially viable products will be portrayed. Ultimately, the book provides a better understanding of the field of redox-active secondary metabolites and also attempts to stimulate further interest in this amazing, facet-rich and thriving area of multidisciplinary research and product development.

Botanical chemistry. --- Oxidation-reduction reaction. --- Plant metabolites. --- Antioxidants. --- Microbial metabolites. --- Metabolites --- Chemical inhibitors --- Plant products --- Electron transfer reaction --- Oxido-reduction --- Redox reaction --- Chemical reactions --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Pharmaceutical technology. --- Biochemistry. --- Pharmacy. --- Pharmaceutical Sciences/Technology. --- Plant Biochemistry. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Composition --- Plant biochemistry.