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This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.

DNA-protein interactions. --- DNA-protein interactions --- Molecular biology --- Physical Phenomena --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- DNA-Binding Proteins --- Biophysical Phenomena --- Chemicals and Drugs --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Biophysics --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- Physics. --- Biochemistry. --- Proteins. --- Cell biology. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Biophysics and Biological Physics. --- Molecular Medicine. --- Cell Biology. --- Biomedical Engineering. --- Biochemistry, general. --- Protein Structure. --- Biochemistry --- Biomolecules --- Systems biology --- DNA-ligand interactions --- Protein binding --- Medicine. --- Cytology. --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Proteins . --- Proteids --- Polypeptides --- Proteomics --- Biological physics --- Physics

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This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.

Chemical structure --- Histology. Cytology --- General biochemistry --- Molecular biology --- General biophysics --- Human biochemistry --- moleculaire structuur --- medische biochemie --- biofysica --- biochemie --- cytologie --- histologie --- eiwitten --- moleculaire biologie

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Japan's Quest for Nuclear Energy and the Price it has Paid: Accidents, Consequences, and Lessons Learned for the Global Nuclear Industry identifies major accidents in Japan that have happened at different stages of the nuclear fuel cycle in Japan, assesses the underlying causes of nuclear accidents, and identifies other systemic problems in the nuclear industry. It provides recommendations on how government, industry and academic institutions can work together toward achieving a zero-accident safety culture.