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As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Toxicology. --- Medical laboratories. --- Zoology. --- Laboratory animals. --- Pharmacology/Toxicology. --- Laboratory Medicine. --- Animal Models. --- Biology --- Natural history --- Animals --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Toxicology --- Pharmacology. --- Biomedical Research. --- Experimental Organisms. --- Biological research --- Biomedical research --- Health Workforce --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Research. --- Technique. --- Physiological effect

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System Center Configuration Manager Current Branch provides a total systems management solution for a people-centric world. It can deploy applications to individuals using virtually any device or platform, centralizing and automating management across on-premise, service provider, and Microsoft Azure environments. In System Center Configuration Manager Current Branch Unleashed, a team of world-renowned System Center experts shows you how to make the most of this powerful toolset. 

The authors begin by introducing modern systems management and offering practical strategies for coherently managing today's IT infrastructures. Drawing on their immense consulting experience, they offer expert guidance for ConfigMgr planning, architecture, and implementation. You'll walk through efficiently performing a wide spectrum of ConfigMgr operations, from managing clients, updates, and compliance to reporting. Finally, you'll find current best practices for administering ConfigMgr, from security to backups. 

Using this guide's proven techniques and comprehensive reference information, you can maximize the value of ConfigMgr in your environment-no matter how complex it is or how quickly it's changing.

Programming --- configuratiebeheersing --- systeembeheer