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Pathology is an inherently subjective discipline, and therefore is often referred to as both an art and a science. Over the years, laboratory physicians have implemented special tissue stains and molecular techniques to limit subjectivity in the discipline. Beginning in the late 19th century, histochemical stains were developed to assess diagnostic biochemical reactions in tissue. Histochemistry has recently seen a resurgence in popularity because of the higher costs of other newer methods. Today, this technique is used by almost every pathology laboratory across the world. This book comprehensively covers all diseases for which that technique plays a central role in diagnosis. Every anatomic region is covered in detail with examples of appropriate staining techniques, and the book is heavily illustrated with over 850 color photomicrographs. This is the first monograph to be published on histochemistry in 15 years, and it is the only one that is diagnostically-oriented.

Diagnosis. --- Histochemistry. --- Histocytochemistry --- Histological Techniques --- Molecular diagnosis. --- Pathology. --- methods. --- methods.

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Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.

Evidence-Based Medicine -- methods. --- Evidence-based medicine. --- Pathology. --- Pathology --- Diagnosis, Laboratory --- Investigative Techniques --- Evidence-Based Practice --- Clinical Medicine --- Medicine --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Occupations --- Disciplines and Occupations --- Evidence-Based Medicine --- Clinical Laboratory Techniques --- Pathology, Clinical --- Methods --- Health & Biological Sciences --- Technological innovations --- Technological innovations. --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Disease (Pathology) --- Medicine. --- Laboratory medicine. --- Health administration. --- Medicine & Public Health. --- Laboratory Medicine. --- Health Administration. --- Diagnosis --- Medical sciences --- Diseases --- Medicine, Preventive --- Medical laboratories. --- Practice of medicine. --- Health facilities --- Laboratories --- Medical practice --- Practice of medicine --- Physician practice acquisitions

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Virtually all sites in the human body can host lesions that simulate neoplasms, and many of these ""pseudotumors"" can simulate neoplasms on all levels of analysis-- clinical, radiologic, and pathologic-- thus they represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection. This book provides the pathologist with detailed morphologic descriptions and diagnostic guidance in recognizing these neoplastic mimics as they occur in the skin. In addition, descriptions and diagnostic guidance are provided for the range of skin lesions that may mimi

Skin --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Diseases --- Diagnosis. --- Pathophysiology.

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With its award-winning, innovative approach, the new edition of Practical Pulmonary Pathology, by Kevin O. Leslie, MD and Mark R. Wick, MD, provides comprehensive, practical guidance in the accurate identification and interpretation of neoplastic and non-neoplastic diseases of the lungs. Lavishly illustrated in full color throughout, this ""one-stop"" resource captures key morphologic patterns for a full range of common and rare conditions and assists in the interpretation of complex diagnostic puzzles. An easily accessible format with a unique ""visual index"" places in-depth diagnostic gu

Lungs --- Diseases --- Diagnosis. --- Lung Diseases --- Lung --- diagnosis --- pathology

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Part of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 3rd Edition, helps you accurately identify and interpret neoplastic and non-neoplastic diseases of the lungs by using a pattern-based approach. Leading diagnosticians in pulmonary pathology guide you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Superb, full-color illustrations capture key pathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance.