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Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.

Life Sciences. --- Cell Biology. --- Receptors. --- Cancer Research. --- Life sciences. --- Oncology. --- Cell receptors. --- Cytology. --- Sciences de la vie --- Cancérologie --- Récepteurs cellulaires --- Cytologie --- Protein-tyrosine kinase --- Tyrosine --- Protein-Tyrosine Kinases --- Protein Kinases --- Phosphotransferases (Alcohol Group Acceptor) --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Chemicals and Drugs --- Receptor Protein-Tyrosine Kinases --- Biology --- Health & Biological Sciences --- Cytology --- Physiological effect --- Structure --- Receptors --- Protein kinases. --- Diseases. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Protein kinase --- Protein phosphotransferases --- Diseases --- Cancer research. --- Proteins. --- Cell biology. --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Proteins . --- Cancer research --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Family and Subfamilies systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the fifty-eight RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, which refers to specific subfamilies of RTKs, along with their unique landmarks.

Chemistry --- Histology. Cytology --- Molecular biology --- Pharmacology. Therapy --- farmacologie --- cytologie --- histologie --- moleculaire biologie --- proteïnen