Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Projektmanagement ist das Rückgrat jeder Organisation, und eine effektive Supervision ist der Schlüssel zum Erfolg. Das Buch gibt einen umfassenden Einblick in die Projektsupervision, inkl. praxisnaher Beispiele und wertvollem Expertenwissen. Mit besonderem Blick auf das zwischenmenschliche Miteinander begleitet dieser kompakte Guide Führungskräfte auf dem Weg zu erfolgreichen Projekten - egal, ob Geschäftsführer, Betriebsleiter oder Qualitätsbeauftragter.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

Histology. Cytology --- General biochemistry --- Molecular biology --- Physiology of nerves and sense organs --- Human physiology --- Pathological biochemistry --- Human medicine --- medische biochemie --- neurochemie --- biochemie --- biomedische wetenschappen --- geneeskunde --- fysiologie --- cytologie --- moleculaire biologie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery. Provides a comprehensive update on the state of knowledge of voltage-gated calcium channels; Examines how calcium channels are pharmacologic targets in the treatment of epilepsy, hypertension, and pain; Explores the new, sophisticated imaging approaches that have increased our ability to measure calcium in live cells; Presents an understanding of the molecular mechanisms that govern calcium channel trafficking and distribution.

Histology. Cytology --- General biophysics --- History of human medicine --- Human physiology --- Neuropathology --- biofysica --- neurologie --- farmacologie --- fysiologie --- cytologie --- histologie