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With people aged 65 years and older currently making up the fastest growing age group throughout the world, the demographic revolution of an aging society will inevitably lead to increased pressure to develop a rationalistic and age-tailored process of diagnosis and treatment among the elderly. As aging people often suffer from several chronic diseases and are being treated with multiple medications concurrently, unwanted drug interactions occur more frequently. Whereas recent approaches have recommended to remove particular drugs from the medication regimen to avoid adverse effects, Drug Therapy for the Elderly underlines both indispensable and dispensable elements of drug treatment, providing the practitioner with: - Background information on the elderly population regarding their needs for particular drugs (with an eye to frailty, co-morbidity patterns, and special sensitivities regarding drug metabolism and excretion) - Practical advice about drug treatment surveillance parameters in the elderly - In-depth discussion of drugs in relation to the elderly with specific diagnoses - Integration of multimorbidity/polypharmacy situations into prioritization schemes - A plan for how to deal with the complexity of polypharmacy situations in a five-minute consultation An original classification of drugs is proposed by the editor which relates the power of effects, prognostic data, and tolerability to a prioritization scoring system. This approach is the first to not only provide a negative listing, but also integrates positive data into an overall assessment for drugs fit for the aged. Therefore, Drug Therapy for the Elderly serves as a timely reference for a wide array of physicians.

Drug interactions. --- Geriatric pharmacology. --- Older people -- Drug use. --- Psychopharmacology. --- Chemotherapy --- Drugs --- Therapeutics --- Adult --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Age Groups --- Persons --- Named Groups --- Aged --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Geriatrics --- Pharmacy, Therapeutics, & Pharmacology --- Older people --- Drug use --- Medicine. --- Pharmacology. --- Internal medicine. --- Geriatrics. --- Medicine & Public Health. --- Geriatrics/Gerontology. --- Internal Medicine. --- Pharmacology/Toxicology. --- Aging people --- Elderly people --- Old people --- Older adults --- Older persons --- Senior citizens --- Seniors (Older people) --- Age groups --- Gerontocracy --- Gerontology --- Old age --- Pharmacology --- Toxicology. --- Chemicals --- Poisoning --- Poisons --- Medicine, Internal --- Toxicology --- Diseases --- Health and hygiene --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Physiological effect

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"Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization"--

Medical innovations. --- Biomedical Research. --- Clinical Medicine. --- Medicine, Clinical --- Experimental Medicine --- Investigational Medicine --- Investigative Medicine --- Research, Biomedical --- Research, Medical --- Medical Research --- Medicine, Experimental --- Medicine, Investigational --- Medicine, Investigative --- Animals, Laboratory --- Innovations, Medical --- Medicine --- Medical technology --- Technological innovations --- Innovations --- Research. --- Health Workforce

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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.

Human medicine --- Biotechnology

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Biotechnology industry. --- Biotechnology --- Clinical medicine --- Drug development. --- Drugs --- Pharmaceutical industry. --- Biomarkers. --- Biomedical Research. --- Clinical Trials as Topic. --- Drug Development --- Pharmacology, Clinical. --- Risk Assessment. --- Translational Science, Biomedical. --- Risk assessment. --- Research. --- organization & administration.

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Sichere Arzneitherapie für ältere Patienten! Menschen im Alter über 65 Jahren bilden die am stärksten wachsende Bevölkerungsgruppe. Ältere Patienten haben häufig mehrere - oft chronische - Erkrankungen. Unerwünschte Arzneimittelwirkungen sind überdurchschnittlich häufig u.a. wegen: - geänderter biologischer Eckdaten (Leberdurchblutung und Nierenfunktion vermindert, mehr Fett- weniger Muskelmasse) - mangelnder Compliance - Vielfachmedikation mit kaum vorhersagbaren Wechselwirkungen Welche Besonderheiten gibt es? Welche Nebenwirkungen/Wechselwirkungen müssen insbesondere beachtet werden - und können ggf. als neue eigenständige Erkrankungen fehlinterpretiert werden? Welche Arzneimittel sind für ältere Patienten ungeeignet bzw. erfordern besondere Vorsicht? NEU Neueste Daten, Statistiken, Key Evidences Wertungssystem für Alterstauglichkeit von Arzneimitteln nach FORTA-Liste Die Lösungsvorschläge und Antworten unter Einbeziehung neuester Daten, Statistiken und Key Evidences für die tägliche Praxis finden Sie in diesem Buch: - Medizinische Sicherheit: Welche Medikamente haben Priorität? Was darf ich weglassen? - Ökonomische Sicherheit: Bessere Arzneitherapie für den Patienten mit gleichzeitig weniger Verschreibungen (= Einhaltung des Arzneimittelbudgets). "Die schwierige Entscheidung ist häufig nicht, welche Therapie gewählt, sondern worauf verzichtet werden kann." Prof. Georg Ertl, Vorsitzender der DGIM 2007/2008 zur Eröffnung der 114. Jahrestagung der DGIM.

Internal medicine. --- General practice (Medicine). --- Geriatrics. --- Pharmacology. --- Pharmacy. --- Internal Medicine. --- General Practice / Family Medicine. --- Geriatrics/Gerontology. --- Pharmacology/Toxicology. --- Geriatric pharmacology.