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The deeper understanding of protein structure now emerging from cutting-edge research is not only illuminating evolutionary and biochemical mechanisms, but also promises enormous ramifications for molecular medicine, as well as for biotechnology, biophysics, biology, genetics, and other molecular sciences. In Protein Structure Prediction: Methods and Protocols, world-class investigators detail their most successful methods-and the theory behind them-for delineating the shape, form, and function of proteins. The protocols range from basic to advanced and include sequence alignment, the prediction of transmembrane protein structure, and the development of suitable folding potentials. There are also techniques for receptor site prediction, the identification of motifs and domains, the comparative modeling of proteins, the docking of peptides and ligands, and ab initio approaches to protein loop and side-chain prediction. To ensure robust and successful experimental results, each protocol contains step-by-step instructions, as well as tips on pitfalls to avoid and how procedures may be optimized for different systems. Comprehensive, accessible, and highly practical, Protein Structure Prediction: Methods and Protocols offers protein researchers, structural biologists, and other investigators a critical synthesis of the latest research results, as well as the vital guidance needed to understand the structure and interaction of proteins and peptides.

Amino acid sequence. --- Models, Molecular. --- Probability. --- Protein Conformation. --- Proteins --- Structure --- Mathematical models. --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Sequence alignment (Bioinformatics) --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Analysis --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Amino acid sequence --- Protein Conformation --- Models, Molecular --- Probability --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Probabilities --- Molecular Models --- Model, Molecular --- Molecular Model --- Molecular Conformation --- Molecular Structure --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Structure&delete& --- Mathematical models

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David Webster explores the notion of desire as found in the Buddhist Pali Canon. Beginning by addressing the idea of a 'paradox of desire', whereby we must desire to end desire, the varieties of desire that are articulated in the Pali texts are examined. A range of views of desire, as found in Western thought, are presented as well as Hindu and Jain approaches. An exploration of the concept of ditthi(view or opinion) is also provided, exploring the way in which 'holding views' can be seen as analogous to the process of desiring. Other subjects investigated include the mind-body relationship, the range of Pali terms for desire, and desire's positive spiritual value. A comparative exploration of the various approaches completes the work.

Buddhism --- Desire --- Doctrines. --- Religious aspects --- Buddhism.

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David Webster explores the notion of desire as found in the Buddhist Pali Canon. Beginning by addressing the idea of a 'paradox of desire', whereby we must desire to end desire, the varieties of desire that are articulated in the Pali texts are examined. A range of views of desire, as found in Western thought, are presented as well as Hindu and Jain approaches. An exploration of the concept of ditthi(view or opinion) is also provided, exploring the way in which 'holding views' can be seen as analogous to the process of desiring. Other subjects investigated include the mind-body relationship, the range of Pali terms for desire, and desire's positive spiritual value. A comparative exploration of the various approaches completes the work.

Buddhism --- Desire --- Doctrines. --- Religious aspects --- Buddhism.

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History of civilization --- Central America --- Mexico --- Mayas --- History --- Antiquities. --- Civilization. --- Maya --- Ethnology. Cultural anthropology --- Mesoamerican --- Maya [style] --- Maya [culture or style]