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Operating rooms (OR) generate big parts of hospital revenues. On the opposite, operating costs are usually high in that complex environment. When waiting times are short before a patient is eligible to use the OR service, there is a social benefit compared to long waiting times. OR’s are thus critical assets to the hospitals and must therefore perform as high as possible. Until now, no measuring instrument exists that quantifies the performance of an OR on all different criteria into one overall score. Therefore, the goal and research question for this study is to explore the possibilities of using the Multi-Criteria Decision Making (MCDM) method to score OR’s based on overall performance. Here, performance comprises efficiency and effectiveness of the performed actions. After consulting the existing literature on the different MCDM methods, the Analytic Hierarchy Process (AHP) was chosen as preferred method to conduct this study. The criteria which will form the basis of the OR performance in this model were carefully selected and subdivided into main and sub criteria. In the AHP, the scores on the different criteria are multiplied with weights determined by OR experts. Hence, fourteen stakeholders were questioned about the mutual importance between each of the selected criteria and that information was transformed into criteria weights. The most important remark that was made about the allocation of the weights, is that almost all stakeholders indicated that quality was the far most important criterion. Henceforth, the quality criterion was on average weighted with almost 50%, thus almost half of the total weight. The scores for the considered OR were on average increasing over the four observed years (2015-2018), with a clear peak in 2018. It could be observed that on average the performance scores from the OR nurses were higher compared to the scores from the surgeons and the anaesthesiologists. This reflection was further analysed, but this trend was not based on the specific weighs given by these respondents. It could be argued that this pattern would not occur with the same analysis for another OR. This research shows that the MCDM, and more specific the AHP method, is feasible for measuring OR performance. It is a versatile method which allows to compare performance scores over different years or to compare different OR’s with each other. The method is highly adjustable to new information and permits to easily reproduce the different scores on the underlying criteria. This allows the user to examine which specific criteria causes the overall performance score to be lower than desired.