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This reprint book is a compilation of the articles and reviews published in the Special issue entitled "Controversies and Recent Advances in Senescence and Aging" in Cells. The Editorial summarises and highlights the contents of the published articles. Aging is the leading predictive factor of many chronic diseases that account for most of the morbidity and mortality worldwide, i.e., neurodegeneration, cardiovascular, pulmonary, renal, and bone diseases, as well as cancers. Oxidative stress and reactive oxygen species generation, the over-production of inflammatory cytokines, the activation of oncogenes, DNA damage, telomere shortening, and the accumulation of senescent cells are all widely accepted mechanisms contributing to aging. Senescence is mainly thought to be provoked by negative cellular stress but might also be induced by physiological developmental stimuli. Senescence is characterized by irreversible cell cycle arrest independent of quiescence and terminal differentiation. The Special Issue entitled "Controversies and Recent Advances in Senescence and Aging", which is contained in this reprint, comprises an excellent collection of original articles and reviews highlighting different novel aspects in the fields of senescence and aging research. They will hopefully stimulate discussions and further research in these fields, which are extremely important in a constantly aging human population.

Aging. --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Physiological effect

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

Medicine --- Physiology --- peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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This reprint contains original research and review articles describing recent advances in our understanding of the transcriptional regulation of cardiac development and disease mechanisms. All articles were originally published in the International Journal of Molecular Sciences (IJMS).

Research & information: general --- Biology, life sciences --- Biochemistry --- pluripotent stem cells --- cardiomyocytes --- cardiac tissue engineering --- human heart --- tissue maturation --- Wilms' tumor suppressor 1 --- cardiomyocyte differentiation --- mouse embryonic stem cells --- myocardial infarction --- YAP --- TEAD1 --- Toll-like receptor --- heart --- TLR4 --- cardiomyocyte --- innate immune responses --- Wilms' tumor suppressor 1 (Wt1) --- cardiac development --- coronary vessel formation --- transcriptional regulation --- cardiac malformation --- epicardium --- epicardial derived cells (EPDCs) --- epithelial mesenchymal transition (EMT) --- cardiac cell fate --- regeneration --- arrhythmogenic cardiomyopathy (ACM) --- lamin A/C --- atomic force microscopy (AFM) --- cell-cell adhesion --- neonatal rat ventricular fibroblasts (NRVF) --- tunneling nanotubes (TNT) --- gene therapy --- cardiovascular diseases --- cardiac regeneration --- cardiac reprogramming --- therapeutic angiogenesis --- growth factors --- reactive oxygen species --- apoptosis --- Bmp signaling --- Hand1 --- Smad --- heart development --- SH3BGR --- cardiac hypertrophy --- SRF signaling --- Hippo signaling --- cardiomyogenic differentiation --- cardiac mesenchymal stromal cell --- hydrogels --- histone deacetylase inhibitors --- translational studies --- gene expression and regulation --- cardiomyopathy --- heart failure --- reverse remodelling --- left ventricular assist device --- pluripotent stem cells --- cardiomyocytes --- cardiac tissue engineering --- human heart --- tissue maturation --- Wilms' tumor suppressor 1 --- cardiomyocyte differentiation --- mouse embryonic stem cells --- myocardial infarction --- YAP --- TEAD1 --- Toll-like receptor --- heart --- TLR4 --- cardiomyocyte --- innate immune responses --- Wilms' tumor suppressor 1 (Wt1) --- cardiac development --- coronary vessel formation --- transcriptional regulation --- cardiac malformation --- epicardium --- epicardial derived cells (EPDCs) --- epithelial mesenchymal transition (EMT) --- cardiac cell fate --- regeneration --- arrhythmogenic cardiomyopathy (ACM) --- lamin A/C --- atomic force microscopy (AFM) --- cell-cell adhesion --- neonatal rat ventricular fibroblasts (NRVF) --- tunneling nanotubes (TNT) --- gene therapy --- cardiovascular diseases --- cardiac regeneration --- cardiac reprogramming --- therapeutic angiogenesis --- growth factors --- reactive oxygen species --- apoptosis --- Bmp signaling --- Hand1 --- Smad --- heart development --- SH3BGR --- cardiac hypertrophy --- SRF signaling --- Hippo signaling --- cardiomyogenic differentiation --- cardiac mesenchymal stromal cell --- hydrogels --- histone deacetylase inhibitors --- translational studies --- gene expression and regulation --- cardiomyopathy --- heart failure --- reverse remodelling --- left ventricular assist device

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Peroxisomes --- Receptors.