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Immunology. Immunopathology --- Pathology of the organs of movement --- immunologie --- reumatologie

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From 22 to 24 October 2006, internationally renowned scientists from the European Union and the United States met in Potsdam near Berlin, Germany, to discuss the future of chronic in?ammatory disease tre- ment.Thetitleofthesymposium,organizedbytheErnstScheringFo- dation,wasImmunotherapyin2020 VisionsandTrendsforTargeting In?ammatory Diseases . The presentations covered the main mechanisms of immunoregu- tion such as peripheral and central tolerance, epigenetic programming, immunologic memory, and regulatory networks in in?ammation as well as novel experimental and clinical approaches for targeting in?am- tion in autoimmunity and transplantation. Group discussions focused on the question of how recent ?ndings in immunological research can lead to improved diagnostics, new drugs, and better therapies. In this regard, beside novel approaches, the individualization of immunomodulatory therapies and the establishment of reliable biomarkers for assessing the speci?c immune situation along with patient response to therapies were discussed. In this volume, the symposium speakers give their view on current topics of immunopathophysiology and immunotherapy. The chapter by Prof. Rikard Holmdahl (Section for In?ammation Research, Lund University, Sweden) deals with the genetic basis of VI Preface in?ammatory diseases by means of gene polymorphisms and its - plications for the ?nding of new therapies. He describes how, based on the proven genetic component of rheumatoid arthritis demonstrated by clinical studies, a search for susceptibility genes in mice m- els was performed, which led to the de?nition of novel pathways - volvedintheimmunopathology ofarthritis.Concludingfromthis,novel therapeutic approaches are proposed which are experimentally proven yet.

Immunology. Immunopathology --- Pathology of the organs of movement --- immunologie --- reumatologie