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This dissertation by Hartmut Vogt explores the impact of early life factors on the development of asthma in children and adults, focusing on gestational age, cord blood immunoglobulin E (IgE), family history, migration, and early childhood vaccination. It presents findings from both national and local Swedish cohorts, utilizing data from the Swedish Prescribed Drug Register to analyze the use of asthma medication as a proxy for asthma development. The study identifies an inverse relationship between gestational age and asthma medication use, with increased risk for preterm and early-term births. It also examines the role of IgE levels and family history in predicting asthma, as well as the effects of migration and pertussis vaccination. The research underscores the importance of gestational development for lung maturation and suggests that environmental changes during childhood can influence asthma risk. Intended for medical professionals and researchers, this work contributes significant insights into the etiology and long-term impacts of asthma.

Asthma --- Prenatal influences. --- Etiology.